Author(s)

Chen Tang ¹, Yingying Shao ¹, Bin Chen ², Xudong Jiang ³

Affiliation(s)

¹ School of Science, Guangxi University of Science and Technology, Liuzhou 545005, Guangxi, China
² Liuzhou Workers' Hospital, Liuzhou 545005, Guangxi, China
³ School of Medicine, Guangxi University of Science and Technology, Liuzhou 545005, Guangxi, China

Corresponding Author

ABSTRACT

To systematically evaluate the clinical effect of botulinum toxin A (BXT-A) on children with spastic cerebral palsy. All clinical randomized controlled trials (RCTs) of BXT-A in children with spastic cerebral palsy were collected from the database establishment to April 20, 2021. Meta-analysis was performed on the extracted data using Review Manager 5.4 and R 4.0 software. A total of 21 studies met the inclusion criteria, including 1357 cases of spastic cerebral palsy and 704 cases in the BTX-A+ rehabilitation group. Meta-analysis results showed that: MAS score [MD=-0.83, 95%CI (-0.86, -0.80), Z=51.03, P<0.05] and GMFM-88 score [MD=5.50, 95%CI (4.40, 6.59), Z=9.85, P<0.05] in BTX-A+ rehabilitation treatment group, GMFM-D score [MD=8.51, 95%CI (5.24, 11.78), Z=5.09, P<0.05], GMFM-E score [MD=8.44, 95%CI (5.16, 11.72), Z=5.04, P<0.05], CSS score [MD=-1.86, 95%CI (-3.07, -0.66), Z=3.03, P<0.05], PRS score [MD=0.85, 95%CI (0.26, 1.44), Z=2.83, P<0.05] were better than the rehabilitation treatment group in these aspects, and the diversity between the two groups was statistically (P<0.05). BTX-A can effectively enhance motor function, and is an effective method for the treatment of children with spastic cerebral palsy.

KEYWORDS

CITE THIS PAPER

Chen Tang, Yingying Shao, Bin Chen and Xudong Jiang. Therapeutic Effect of Botulinum Toxin a on Children with Spastic Cerebral Palsy: Meta-analysis. Advances in Educational Technology and Psychology (2021) 5: 191-199. DOI: http://dx.doi.org/10.23977/aetp.2021.55025.

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