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  4. Vol 5, Issue 9, 2023

Research Progress on Anti-Epileptic Mechanism of Acorus Tatarinowii Schott

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DOI: 10.23977/medcm.2023.050914 | Downloads: 5 | Views: 309

Author(s)

Shi Yilan 1, Liu Yutang 2, Zhang Meng 1, Du Huiyu 1

Affiliation(s)

1 First Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China
2 Thirteen Departments of Encephalopathy, Xi'an Traditional Chinese Medicine Encephalopathy Hospital, Xi'an, Shaanxi, China

Corresponding Author

Liu Yutang

ABSTRACT

Epilepsy is a disease that seriously affects human physical and mental health, causing a great burden on society and families. Acorus tatarinowii Schott has the effects of opening orifices and eliminating phlegm, awakening mind and benefiting intelligence, resolving dampness and appetizing. It is often used to treat various diseases in traditional medicine, and it has a good therapeutic effect on epilepsy. By sorting out the mechanism of Acorus tatarinowii Schott in the treatment of epilepsy, it provides a theoretical basis for clinical use of this traditional Chinese medicine. Therefore, this article reviews its mechanism of action as follows.

KEYWORDS

Epilepsy, Acorus tatarinowii Schott, Action mechanism

CITE THIS PAPER

Shi Yilan, Liu Yutang, Zhang Meng, Du Huiyu, Research Progress on Anti-Epileptic Mechanism of Acorus Tatarinowii Schott. MEDS Chinese Medicine (2023) Vol. 5: 113-117. DOI: http://dx.doi.org/10.23977/medcm.2023.050914.

REFERENCES

[1] Zhang Liqun. Study on the pathogenesis and treatment of epilepsy [J]. Medical information, 2021, 34 (16):44-46. 
[2] Zhong Gansheng. Chinese Materia Medica (4th Edition) [M]. Beijing: China Traditional Chinese Medicine Press, 2016:160-161. 
[3] Mei Tingting, Yan Jun, Chen Jing. Overview of Chemical Constituents and Pharmacological Effects of Acorus tatarinowii Schott [J]. Traditional Chinese Medicine Information, 2022, 39(04):77-80 + 89. DOI: 10. 19656 / j. cnki. 1002-2406. 20220415. 
[4] Shi Jianhong, Ji Liting, Luo Qihan, etc. Research progress on chemical constituents, pharmacological effects and predictive analysis of quality markers of Acorus tatarinowii Schott [J]. Chinese patent medicine, 2021, 43 (05): 1286-1290. 
[5] Luo Qiuzhu, Yang Dihua, Wu Zipeng et al. Analysis of volatile oil components in Acorus tatarinowii Schott by gas chromatography-mass spectrometry [J]. Chinese Pharmacoeconomics, 2021, 16(08):116-120. 
[6] Stafstrom, Ernest C. Epilepsy: Mechanisms, models, and translational perspectives [J]. CRC Press, 2010, 662p. 
[7] Huang C, et al. Alpha-asarone from Acorus gramineus alleviates epilepsy by modulating A-Type GABA receptors [J]. Neuropharmacology, 2013, 65: 1-11. 
[8] Li QQ, et al. Effect of α-asarone on ethanol-induced learning and memory impairment in mice and its underlying mechanism[J]. Life Sci, 2019, 238:116898. 
[9] Xu Feifei, Li Qinqing, Chu Shifeng and so on. Research progress on the neuropharmacological effects and mechanisms of α-and β-asarone, the main components of volatile oil from Acorus tatarinowii Schott [J]. Research and development of natural products, 2020, 32 (11):1969-1979. DOI: 10. 16333 / j. 1001-6880. 2020. 11. 021. 
[10] Miao Jingkun, Wu Xiaomei, Chen Qixiong and so on. Experimental study on antiepileptic effect of α-asarone from Acorus tatarinowii Schott [J]. Chinese Pharmacology Bulletin, 2008, 24 (12):1660-1662. 
[11] Wu Yuan, Pang Jiarong, Zheng Jinou, etc. Dynamic study of neuronal apoptosis in epileptic rats induced by kainic acid [J]. Journal of Clinical Neuroelectrophysiology, 2007 (03): 131-134. 
[12] Chan JA, Krichevsky AM, Kosik KS. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells [J]. CancerRes, 2005, 65(14):6029-6033. 
[13] Brodie C, Blumberg PM. Regulation of cell apoptosis by Protein kinase c delta. Apoptosis. 2003; 8(1):19~27. 
[14] Wang Kunfang, Zhu Na, Sha Zijun, etc. Based on network pharmacology to explore the anti-epileptic mechanism of high-frequency drugs containing Acorus tatarinowii Schott [J]. Henan TCM 2021, 41(03):440-447. DOI:10. 16367/ j. issn. 1003-5028. 2021. 03. 0102. 
[15] Binder D K, Steinhäuser C. Role of astrocytes in epilepsy[J]. Cold Spring Harbor Perspectives in Medicine, 2015, 5(3): a022434. 
[16] Robel S, Berninger B, Gãtz M. The stem cell potential of glia: lessons from reactive gliosis[J]. Nature Reviews Neuroscience, 2011, 12(2):88-104. 
[17] Zhao Mingming, Xu Wenqing, Tao Kaige and so on. Effects of α-asarone, the core metabolic effector of Acorus tatarinowii Schott, on neuronal morphology and astrocyte activation in hippocampus of epileptic young rats [J]. Shandong Medicine, 2021, 61(17):38-41. 
[18] Annamaria K, Andras Mi Agnes K, et al. Seizure neurotransmitter release, and gene expression are closely related in the striatum of 4-aminopyridine-treated rats [J]. Epilepsy Research. 2003. 55:117- 129. 
[19] Zhu Xuanxuan, Dai Bing, Yin Kun and so on. Effect of Dingxian Pill on the content of neurotransmitters in the brain and the expression of c-fos in hippocampus of epileptic rats kindled by pentylenetetrazol [J]. Chinese Journal of Traditional Chinese Medicine, 2011, 29 (03):468-470. DOI : 10. 13193 / j. archtcm. 2011. 03. 22. zhuxx. 047. 
[20] Gong Lei, Xu Jie, Gong Qihai et al. Effect of volatile oil from Acorus tatarinowii Schott on c-fos expression in lithium-pilocarpine-induced epileptic rats [J]. Modern Medicine and Health, 2014, 30(13):1921-1923 + 1926. 
[21] Li Man, Li Guanglai. Regulation of volatile oil from Acorus tatarinowii Schott on c-fos gene expression in the brain of epileptic rats induced by meijiemian [J]. Journal of Cardio-cerebrovascular Diseases of Integrated Traditional Chinese and Western Medicine, 2009, 7(01):68-69. 
[22] West AE, Chen WG, Dalva MB, et al. Calcium regulation of neuronal gene expression[J]. Proc Natl AcadSci, 2001; 98:11024-11031. 
[23] Miao Jingkun, Chen Qixiong, Li Chun et al. The effect of α-asarone on the regulation of hippocampal calcium homeostasis in epileptic rats [J]. Chinese Journal of Clinical Pharmacology, 2013, 29(02):139-141. DOI: 10. 13699 / j. cnki. 1001-6821. 2013. 02. 002. 
[24] Thakor AS, Giussani DA. The role of calcitonin gene-related Peptide in the in vivo pituitary-adrenocortical response to acute hypoxemia in the late-gestation sheep fetus[J]. Endocrinology, 2005, 146(11):4871- 4877. 
[25] Feng Junlin, Jiang Jingzi, Lu Jianhua and so on. Study on the levels of S100B and CGRP in serum and cerebrospinal fluid of epileptic rats induced by kainic acid [J]. Journal of stroke and neurological diseases, 2010, 27(06):496-498. DOI: 10. 19845 / j. cnki. zfysjjbzz. 2010. 06. 004. 
[26] Gong Lei, Xu Jie, Gong Qihai and so on. Effect of volatile oil of Acorus tatarinowii Schott on the expression of CGRP and NSE in serum and cerebrospinal fluid of epileptic rats induced by lithium chloride-pilocarpine [J]. Journal of Qiannan Medical College, 2014, 27 (02):86-91. 
[27] Dai Baiyun, Wu Shaohua. Research progress on the effective components and mechanism of Acorus tatarinowii Schott in the treatment of epilepsy [J]. Southwest Military Medical Doctor, 2011, 13 (01):86-87. 
[28] Yang Zhixian, Qin Jiong, Chang Xingzhi and so on. Effects of carbon monoxide and nitric oxide on apoptosis of hippocampal neurons in rats with febrile seizures [J]. Chinese Journal of Contemporary Pediatrics, 2006 (03):231-234. 
[29] Yang Haigan, Cao Rui, Wang Maojie, etc. Effect of Acorus tatarinowii Schott water extract on NO expression in human brain glial cells [J]. Chinese Medical Journal, 2019, 16(25):24-26 + 31. 
[30] Chang Lin, Wang Xiaoshan. Progress in epidemiological investigation of epilepsy in China [J]. International Journal of Neurology and Neurosurgery, 2012, 39 (02):161-164. DOI: 10. 16636 / j. cnki. jinn. 2012. 017. 
[31] Xiao Wei. Analysis of medication rules for the treatment of epilepsy based on data mining [D]. Jinan: Shandong University of Traditional Chinese Medicine, 2017.

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