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  4. Vol 4, Issue 6, 2023

Exploration on the mechanism of quercetin in treating breast duct dilation based on network pharmacology

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DOI: 10.23977/medsc.2023.040613 | Downloads: 4 | Views: 288

Author(s)

Na Zhang 1, Zhi Li 2, Zhongren Gai 1, Kenian Pan 1, Xinyi Yang 1

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
2 Xi'an Affiliated Hospital of Shaanxi University of Chinese Medicine, Xi'an, Shaanxi, 710021, China

Corresponding Author

Zhi Li

ABSTRACT

Dilation of mammary duct is a chronic nonbacterial inflammation of the breast based on breast duct obstruction, secondary breast duct dilation, periductal inflammation, and plasma cell infiltration.Dilation of mammary duct is a chronic nonbacterial inflammation of the breast based on breast duct obstruction, secondary breast duct dilation, periductal inflammation, and plasma cell infiltration. To analyze the mechanism of quercetin in the treatment of Dilation of mammary duct based on network pharmacology and further explore the modern pharmacological action of quercetin, The related targets of "quercetin" were screened from the TCMSP database; Relevant targets of " Dilation of mammary duct were screened from Genecards database. After the common protein target information of the two was obtained through venny, the protein interaction network was constructed using Cytoscape software, and the hub gene was screened. Use David platform to conduct GO, KEGG and other enrichment analysis on the same targe. Conclusion: There are138 nodes and 2608 edges in the PPI network. These targets mainly include AKT1, IL-6, TP53, TNF, VEGFA, CASP3, IL1B, EGFR, JUN, etc. The results of GO enrichment analysis showed that quercetin is involved in 666 biological processes, 98 cellular composition, and 128 molecular functions. It mainly plays a role in AGE-RAGE signaling pathway in diabetic complications, Pathways in cancer, Lipid and atherosclerosis, and other pathways, Conclusion: Quercetin exerts anti-inflammatory effects in Dilation of mammary duct through multiple pathways and multiple targets, which is a new option for the treatment of Dilation of mammary duct. 

KEYWORDS

Dilation of mammary duct; quercetin; Network Pharmacology; mechanism of action

CITE THIS PAPER

Na Zhang, Zhi Li, Zhongren Gai, Kenian Pan, Xinyi Yang, Exploration on the mechanism of quercetin in treating breast duct dilation based on network pharmacology. MEDS Clinical Medicine (2023) Vol. 4: 83-90. DOI: http://dx.doi.org/10.23977/medsc.2023.040613.

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