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  4. Vol 5, Issue 9, 2023

Exploration of the mechanism of action of turmeric in improving ischemic stroke based on network pharmacology

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DOI: 10.23977/medcm.2023.050908 | Downloads: 23 | Views: 384

Author(s)

Jinjuan Mao 1, Lei Feng 2, Xiaoming Wang 2

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
2 Department of Neurosurgery, Xidian Group Hospital, Xi'an, Shaanxi, 710077, China

Corresponding Author

Xiaoming Wang

ABSTRACT

In order to preliminarily explore the molecular mechanism of turmeric to improve ischemic stroke with the help of network pharmacology. Based on the pharmacological analysis platform of traditional Chinese medicine system, we screened the effective ingredients of drugs and analyzed various effective ingredients of traditional Chinese medicine using the Swiss target prediction database. Based on STRING combined with Cytoscape 3.5.1, we conducted protein interaction analysis on cross targets, and then conducted GO function and pathway enrichment analysis on cross genes. The number of active ingredients screened for turmeric was 3, the number of targets was 107, and the number of targets for ischemic stroke was 1159.19 cross genes were obtained, among which NR1H3, ESR2, ESR1, NOS2, SREBF2, PPARG, PPARA, NOS2 may be key targets for the role of turmeric in ischemic stroke. Through GO function and pathway enrichment analysis, 10 pathways were identified. The PPAR signaling pathway, arachidonic acid metabolism, and endocrine factors regulate calcium reabsorption, endocrine resistance, insulin resistance, 5-hydroxytryptaminergic synapses, and estrogen signaling pathways (p<0.05). While arachidonic acid metabolism and endocrine factors regulate calcium reabsorption, 5-hydroxytryptaminergic synapses, and estrogen signaling pathways.

KEYWORDS

Network pharmacology; ischemic stroke; turmeric

CITE THIS PAPER

Jinjuan Mao, Lei Feng, Xiaoming Wang, Exploration of the mechanism of action of turmeric in improving ischemic stroke based on network pharmacology. MEDS Chinese Medicine (2023) Vol. 5: 64-71. DOI: http://dx.doi.org/10.23977/medcm.2023.050908.

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