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  4. Vol 5, Issue 7, 2023

Mechanism of Action of Baohe Pills in Improving Functional Dyspepsia

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DOI: 10.23977/medcm.2023.050707 | Downloads: 23 | Views: 389

Author(s)

Xiangqian Yang 1, Yangyang Wang 1, Lin Bai 1, Tiaotiao Miao 1, Xinli Wen 2

Affiliation(s)

1 Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi, 712046, China
2 Shaanxi Traditional Chinese Medicine Hospital, Xi'an, Shaanxi, 710000, China

Corresponding Author

Xinli Wen

ABSTRACT

The aim of this study was to predict the mechanism of action of Baohe Pill in the treatment of functional dyspepsia using network pharmacology. Predict the main active ingredients and action targets of Baohe Pill by TCMSP platform database of Traditional Chinese Medicine Systematic Pharmacological Analysis Platform, and convert the collected drug targets into gene names using Uniprot database; obtain FD genes by GeneGards, TTD, OMIM database, and use Cytoscape 3. 9.0 to visualize the "drug-ingredient -target" network visualization; and protein-protein interaction (PPI) network by using String platform; GO and KEGG analysis of common targets by using Metascape database; molecular docking by using AutoDock software to verify the binding activity of active ingredients to target proteins. After database display analysis, 107 active ingredients, 511 potential action targets and 2560 FD disease targets of Bohol Pill were screened. By KEGG analysis, GO analysis yielded 6382 biological process entries, 1101 molecular function entries, 586 cellular component entries, and 291 pathways.

KEYWORDS

Network pharmacology, Baohe pill, Functional dyspepsia, Molecular docking, Mechanism of action

CITE THIS PAPER

Xiangqian Yang, Yangyang Wang, Lin Bai, Tiaotiao Miao, Xinli Wen, Mechanism of Action of Baohe Pills in Improving Functional Dyspepsia. MEDS Chinese Medicine (2023) Vol. 5: 48-55. DOI: http://dx.doi.org/10.23977/medcm.2023.050707.

REFERENCES

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[2] Wang Jiajun, Yang Xianjuan, Wang Liying, et al.Analysis of the network pharmacological mechanism of Huanglian Houpu Tang to improve ulcerative colitis[J]. Chinese Journal of Experimental Formulas,2022,28(13):217-224.
[3] Zheng Xuerong, Huang Xuefeng, Huang Chunyuan. Exploring the mechanism of action of Wu Zhu Yu Tang for migraine based on network pharmacology and molecular docking method [J]. Clinical Research in Traditional Chinese Medicine, 2022, 14(10):6-12. 
[4] Wang Huilin, Zhang Liping. Exploring the mechanism of action of Sibei San in the treatment of functional dyspepsia based on network pharmacology [J]. World Traditional Chinese Medicine, 2021, 16(10): 1507-1513. 
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