Education, Science, Technology, Innovation and Life
Open Access
Sign In
  1. Home
  2. Journals
  3. MEDS Chinese Medicine
  4. Vol 5, Issue 7, 2023

Research Progress on the Formation Mechanism of Renal Fibrosis and the Treatment of Chinese and Western Medicine

Download as PDF

DOI: 10.23977/medcm.2023.050704 | Downloads: 16 | Views: 377

Author(s)

Nong Ting 1, Zhang Xiaofeng 2

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
2 Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi'an, Shaanxi, 710003, China

Corresponding Author

Zhang Xiaofeng

ABSTRACT

Renal fibrosis (RF) is a major pathological cause of late progression of chronic kidney disease and has seriously jeopardized the quality of life of people worldwide. In recent years, with the research on the mechanism of action of renal fibrosis, it has been found that there are many causative factors of renal fibrosis, and modern clinical research has achieved insufficient efficacy for the treatment of renal fibrosis, but the therapeutic effect varies from person to person. The combination of pharmacology indicates that Chinese medicine has shown unique efficacy and application prospects in the prevention and treatment of renal fibrosis. This article is a review of the formation mechanism of renal fibrosis and the progress of research on the role of Chinese and Western medicine in the treatment of RF.

KEYWORDS

Renal fibrosis; Traditional Chinese medicine; TGF-β; Western medicine

CITE THIS PAPER

Nong Ting, Zhang Xiaofeng, Research Progress on the Formation Mechanism of Renal Fibrosis and the Treatment of Chinese and Western Medicine. MEDS Chinese Medicine (2023) Vol. 5: 24-30. DOI: http://dx.doi.org/10.23977/medcm.2023.050704.

REFERENCES

[1] Bikbov B, Purcell C A, Levey A S, et al. GBD Chronic Kidney Disease Collaboration: Global, regional, and national burden of chronic kidney disease, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017[J]. Lancet, 2020, 395(709-733): 32061315.
[2] Leader C J, Kelly D J, Sammut I A, et al. Spironolactone mitigates, but does not reverse, the progression of renal fibrosis in a transgenic hypertensive rat[J]. Physiological Reports, 2020, 8(10): e14448.
[3] Ruiz-Ortega M, Rayego-Mateos S, Lamas S, et al. Targeting the progression of chronic kidney disease[J]. Nature Reviews Nephrology, 2020, 16(5): 269-288.
[4] Nogueira A, Pires M J, Oliveira P A. Pathophysiological mechanisms of renal fibrosis: a review of animal models and therapeutic strategies [J]. In vivo, 2017, 31(1): 1-22.
[5] Lama G, Ferraraccio F, Iaccarino F, et al. Pelviureteral junction obstruction: correlation of renal cell apoptosis and differential renal function [J]. The Journal of urology, 2003, 169(6): 2335-2338.
[6] Barnes J L, Gorin Y. Myofibroblast differentiation during fibrosis: role of NAD (P) H oxidases [J]. Kidney international, 2011, 79(9): 944-956.
[7] Zhu Qingqing, Li Xueling, Zhong Yifei. Progress in treatment of renal interstitial fibrosis with traditional Chinese medicine and western medicine [J]. Journal of Traditional Chinese Medicine, 2019 (1): 7.
[8] Zhao AQ, Zhang XM, Li RS, et al. Mechanism, prevention and treatment of renal tubulointerstitial fibrosis. Medical Review, 2006, 12 (13): 3.
[9] Wang W. Koka V, Lan HY [J]. Transforming growth factor-beta and Smad signalling in kidney diseases. Nephrology (Carlton), 2005, 10: 48-56.
[10] Lan H Y. Diverse roles of TGF-β/Smads in renal fibrosis and inflammation [J]. International journal of biological sciences, 2011, 7(7): 1056.
[11] Gupta S, Clarkson M R, Duggan J, et al. Connective tissue growth factor: potential role in glomerulosclerosis and tubulointerstitial fibrosis[J]. Kidney international, 2000, 58(4): 1389-1399.
[12] Liu Huafeng, Yao Cuiwei, Huangfu Changmei, et al. Effect of interleukin-18 on renal tubular atrophy and interstitial fibrosis [J]. Chinese Journal of Integrated Traditional Chinese and Western Medicine Nephropathy, 2004,5 (12): 5.
[13] Chen S, Zhang M, Li J, et al. β‐catenin‐controlled tubular cell‐derived exosomes play a key role in fibroblast activation via the OPN‐CD44 axis[J]. Journal of Extracellular Vesicles, 2022, 11(3): e12203.
[14] Xu Jianhua, Xiao Hongbo, Cheng Yuhua et al. Effect of Pirfenidone on renal interstitial fibrosis in rats[J].Chinese Journal of Modern Medicine, 2017, 27(19): 1-6.
[15] Tomita M, Asada M, Asada N, et al. Bmp7 maintains undifferentiated kidney progenitor population and determines nephron numbers at birth[J]. PloS one, 2013, 8(8): e73554.
[16] Liu Daoqin, Zhang Daoyou. Research Advances in the Role of Bone Morphogenetic Protein-7 in Fibrosis of Chronic Kidney Disease [J]. Medical Recapitulate 2015, 21(9): 1579-1581.
[17] Zhuang Q, Ma R, Yin Y, et al. Mesenchymal stem cells in renal fibrosis: the flame of cytotherapy [J]. Stem cells international, 2019, 2019.
[18] Nagaishi K, Mizue Y, Chikenji T, et al. Mesenchymal stem cell therapy ameliorates diabetic nephropathy via the paracrine effect of renal trophic factors including exosomes [J]. Scientific reports, 2016, 6(1): 1-16.
[19] Liu Xiaoqian, Yan Juntang, Ma Chunlei, et al. Research of TCM Etiology and Pathogenesis of Renal Interstitial Fibrosis[J]. Liaoning Journal of Traditional Chinese Medicine, 2011, 38(12): 2373-2376.
[20] Jia Xiuqin, Li Xuemei. Exploration of the rules of anti-nephrogenic drug use in Chinese medicine [J]. Chinese Journal of Integrated Chinese and Western Medicine and Nephrology, 2006, 7(12):739-740.
[21] Chen QJ, Yang L, Wang F, et al. Effects of Astragalus membranaceus on the proliferation and expression of transforming growth factor-β1 in human renal mesenchymal fibroblasts[J]. Journal of Zhengzhou University: Medical Edition, 2005, 40(5):3.
[22] Lu Xun, Wei Minggang. Protective effects of astragalus polysaccharide on interstitial fibrosis in rats[J]. Chinese Journal of Traditional Chinese Medicine, 2014, 29(6):4.
[23] Li Na, Wang Fengyun, Zheng Yan, et al. Ameliorative effect of Panax notoginseng on renal fibrosis in rats with diabetic nephropathy[J]. Chinese Patent Medicine, 2022(009):044.4
[24] Wei Jianbo, Liu Qin, Zhong Yu, et al. Experimental study on the interventional effect of rhododendron on interstitial fibrosis in rats[J]. Zhejiang Journal of Integrative Medicine, 2013, 23(5):3.
[25] Wang Xiaoling, Wang Jianqin, Xia Yanling, et al. Study on the inhibitory effect of rhodopsin on human renal fibroblasts [J]. Chinese Journal of Integrated Chinese and Western Medicine and Nephrology, 2002, 3(11):3.
[26] Cheng Q, Yu LF, Shi LZ, et al. Effect of Cordyceps sinensis on renal pathology in 5/6 nephrectomized rats [J]. Chinese Journal of Kidney Diseases, 1994, 10(1): 30-30.
[27] Tang Jinhui, Zhan Chengye. Inhibitive Effect of TanshinoneⅡA on Renal Interstitial Fibrosis in Rats [J]. Journal of Internal Intensive Medicine, 2008, 14(1): 16-18.
[28] Liu Jinsong, Lin Zhe, Zheng Yanjiao. Effects of Renfukang on the expression of transforming growth factor-β_1, Smad2, Smad7 in rats with renal fibrosis model [J]. World Traditional Chinese Medicine, 2018, 13(12):5.
[29] Wu F, He LQ, Zhang XZ, et al. Effects of anti-fibrin flush on oxidative stress in renal tissues of rats with unilateral ureteral obstruction[J]. Chinese Journal of Integrated Chinese and Western Medicine and Nephrology, 2009, 10(12).
[30] Fu X, Li Jun, Yang SM, et al. Experimental study on the effect of Huangqi Danshen granules on the intervention of Wnt/β-catenin signaling pathway in renal fibrosis[J]. World Science and Technology - Modernization of Chinese Medicine, 2014, 000(001):103-108.
[31] Xiang Caichun, Xiong Qingjun, Zeng Lihua. Experimental study on the intervention of PCIII, IV-C and LN in rats with renal fibrosis with the formula of Yielding Kidney and Invigorating Blood[J]. Sichuan Traditional Chinese Medicine, 2011, 29(3):4.
[32] Zeng Xuejiao, Zhang Shengyong. Effect of Huangkui capsule on renal fibrosis in a model of chronic renal failure [J]. Chinese Journal of Integrated Chinese and Western Medicine and Nephrology, 2008, 9(9): 804-805.

Subscription
E-Mail Alert
Most popular papers
Call for Special Issue
Publication Ethics & OA Statement
Plagiarism Policy
Contact Us
Downloads: 4331
Visits: 172180

Sponsors, Associates, and Links

All published work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2016 - 2031 Clausius Scientific Press Inc. All Rights Reserved.