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  4. Vol 5, Issue 6, 2023

Meta-analysis of Xiehuang Powder as a Basic Formula for the Treatment of Oral Ulcers

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DOI: 10.23977/medcm.2023.050612 | Downloads: 8 | Views: 319

Author(s)

Xiaojing Zhu 1, Yuanshan Tang 2, Lu Cheng 1, Ruyu Teng 1

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
2 Xi'an Hospital of Traditional Chinese Medicine, Xi'an, Shaanxi, 710021, China

Corresponding Author

Yuanshan Tang

ABSTRACT

This study aims to evaluate the effectiveness of Xiehuang Powder as a basic formula for treating oral ulcers. We systematically searched the relational clinical randomized controlled trials (RCTs) conducted in the CNKI, VIP, WFPD, and CBM databases, focusing on the use of Xiehuang Powder as a basic formula for treating oral ulcers (oral ulcer, OU). Strict inclusion and exclusion criteria were applied to select relevant studies, and data were extracted. The data were analyzed using RevMan 5.3 software. Resultly, fifteen articles involving 1,167 patients were included in the meta-analysis. All articles reported the overall clinical effectiveness rate, seven articles reported the recurrence rate, eight articles reported adverse reactions, three articles reported the healing time of oral ulcers, and two articles assessed changes in inflammatory factors. The meta-analysis results showed that the overall clinical effectiveness rate of Xiehuang Powder as a basic formula for treating oral ulcers was higher than that of conventional Western medicine treatment (RR=1.27, 95% CI: 1.21-1.34, P<P<0.00001). The recurrence rate was lower in the Xiehuang Powder group compared to the conventional Western medicine group (RR=0.35, 95% CI: 0.26-0.49, P<0.00001). There was no significant difference in the incidence of adverse reactions between the two groups (RR=0.57, 95% CI: 0.17-1.93, P=0.37). Furthermore, the healing time was shorter in the Xiehuang Powder group than in the conventional Western medicine group (MD=-4.42, 95% CI: -8.17 to -0.8, P=0.02). Thus it can be seen that Xiehuang Powder, as a basic formula, demonstrates effective treatment for oral ulcers, reducing the recurrence rate, alleviating inflammatory reactions, and accelerating the healing time of oral ulcers, thereby improving patients' quality of life. However, the number of high-quality trials available for analysis is limited, and further validation through more high-quality and high-level clinical studies is warranted.

KEYWORDS

Oral ulcers; Xiehuang Powder; Meta-analysis

CITE THIS PAPER

Xiaojing Zhu, Yuanshan Tang, Lu Cheng, Ruyu Teng, Meta-analysis of Xiehuang Powder as a Basic Formula for the Treatment of Oral Ulcers. MEDS Chinese Medicine (2023) Vol. 5: 62-71. DOI: http://dx.doi.org/10.23977/medcm.2023.050612.

REFERENCES

[1] Li GX, Zhan YY, Wang YL, et al. Etiology, classification and clinical manifestation of chronic oral ulcer [J]. Journal of Dermatology and Venereology, 2020, 42(1):31-33. 
[2] Zhang YL, Wang S. Research progress on the etiology, pathogenesis, and clinical treatment of recurrent oral ulcers [J]. General Dental Medicine E-Journal, 2016, 3(19): 3-4. 
[3] He Xiaoming. Analysis of clinical related pathogenic factors and research on TCM syndromes of recurrent oral ulcer [D]. Hubei University of Chinese Medicine, 2020. 
[4] Liu Guofu. Clinical evaluation of Xiehuang Decoction on treating Recurrent oral uleer patients [D]. Nanjing University of Chinese Medicine, 2010. 
[5] Li Y. Clinical observation of Xiehuang Powder combined with Daochi Powder in the treatment of recurrent oral ulcers [J]. Journal of Modern Integrated Traditional Chinese and Western Medicine, 2018, 27(09): 999-1001+1007. 
[6] Fan Yushan. Clinical Observation of Xiehuang Powder in the Treatment of Recurrent Oral Ulcer of Heart and Spleen Accumulation Heat Type [D]. Shanxi University of Chinese Medicine , 2019. 
[7] Wu H. Clinical study of modified Xiehuang Powder in the treatment of recurrent oral ulcers [J]. Chinese Clinical Research, 2020, 12(18): 65-66. 
[8] Zhao Ziyun. Clinical observation of Modified Xiehuang Decoction in treating recurrent oral ulcer patients (pathogenic ire hidden in spleen and stomach) [D]. Chengdu University of Traditional Chinese Medicine, 2019. 
[9] Chen ZM, Ren H. Clinical observation of Xiehuang Powder combined with Daochi Powder in the treatment of recurrent oral ulcers [J]. New Traditional Chinese Medicine, 2014, 46(05): 108-110. 
[10] Chen CH, Zhang L, Wang PC. Clinical observation on 50 cases of recurrent ulcerative stomatitis in children with latent fire in spleen and stomach type adjuvantly treated by modified Xiehuang San [J]. Journal of Pediatrics of Traditional Chinese Medicine, 2022, 18(2):64-67. 
[11] Huan WY. Clinical study of modified Xiehuang Powder in the treatment of recurrent oral ulcers [J]. Primary Medical Forum, 2015, 19(06): 767-768. 
[12] Liang GM. Clinical study of self-made Xiehuang Powder in the treatment of oral ulcers [J]. Medical Frontier, 2013(30): 30-31. 
[13] Wang HG, Cheng H. Study on the efficacy of modified Xiehuang Powder in the treatment of recurrent oral ulcers [J]. Asia-Pacific Traditional Medicine, 2012, 8(05): 42-43. 
[14] Wu M, Yang SF. Clinical observation of Xiehuang Powder with Daochi Powder in the treatment of recurrent aphthous ulcers: A study of 42 cases [J]. Chinese Ethnic and Folk Medicine, 2016, 25(11): 62+64. 
[15] Li DS. Evaluation of the therapeutic effect of Xiehuang Powder with Daochi Powder combined with Western medicine in the treatment of recurrent oral ulcers [J]. Shenzhen Journal of Integrated Traditional Chinese and Western Medicine, 2019, 29(01): 38-39. 
[16] Li YX. Clinical observation of integrated traditional Chinese and Western medicine in the treatment of recurrent oral ulcers [J]. Chinese Journal of Rehabilitation Medicine, 2016, (1): 9-10. 
[17] Gao L, Chen XN. Clinical observation of Daochi Powder combined with Xiehuang Powder in the treatment of recurrent oral ulcers [J]. Jiangsu Traditional Chinese Medicine, 2012, 44(08): 39-40. 
[18] Li JL. Treatment of pediatric spleen-stomach damp-heat type oral ulcers with modified Xiehuang Powder [J]. New Traditional Chinese Medicine, 2008(11): 78. 
[19] Dai LM, Dai LP, Chen YJ, et al. Study on the therapeutic effect and mechanism of Kangfuxin Solution on the traumatic oral ulcer model in rats [J]. Chinese Journal of Traditional Medicine and Clinical Pharmacology, 2021, 12(06): 25-29. 
[20] Chen QM. Oral Mucosal Diseases[M]. Beijing: People's Health Publishing House, 2000: 64-69. 
[21] Liu YG. Clinical efficacy observation of modified Xiehuang Powder in the treatment of oral ulcers [J]. Chinese Medicine Modern Distance Education. 2013. 11(22): 36. 
[22] Yu QX, Sun XJ, Guo WH, et al. Research progress on the clinical application of Xiehuang Powder [J]. Asia-Pacific Traditional Medicine. 2021. 17(04): 213-216. 
[23] Yu SP, Guo RX, Li J, et al. Pharmacological study of Xiehuang Powder with modification on analgesic, anti-inflammatory, and gastric function in mice [J]. Journal of Chengdu University of Traditional Chinese Medicine. 2008. 31(04): 65-66. 
[24] Zhang MQ. Modern Clinical Formulas[M]. Beijing: People's Health Publishing House, 2004(04): 48-49.

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