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The Pathway in Acute Ischemic Stroke: A Review

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DOI: 10.23977/medsc.2023.040414 | Downloads: 14 | Views: 375

Author(s)

Yu Quanyi 1, Lin Hai 1

Affiliation(s)

1 Shaanxi University of Traditional Chinese Medicine, Xianyang, China

Corresponding Author

Lin Hai

ABSTRACT

Ischemic stroke is characterized by sudden loss of blood flow to specific regions of the brain and is a major cause of permanent disability and one of the leading causes of death worldwide. Sprouty-related EVH1 structural domain containing protein 1 (Spred1) is a recognized physiological inhibitor of the Ras/Raf-1/ERK pathway, and it has been shown that inhibition of Spred1 gene expression in ischemic mice contributes to cerebral angiogenesis and neurogenesis and further improves behavioral recovery through activation of the threonine kinase (AKT) and extracellular signal-related kinase (ERK) signaling pathways. We discuss the role of Spred1/ERK/VEGF signaling pathway activation in acute ischemic stroke, providing a positive panorama and suggesting that Spred1, vascular endothelial growth factor (VEGF) targets may be a promising pharmacological strategy for the treatment of ischemic stroke patients in the near future.

KEYWORDS

Acute ischemic stroke; Spred1; VEGF

CITE THIS PAPER

Yu Quanyi, Lin Hai, The Pathway in Acute Ischemic Stroke: A Review. MEDS Clinical Medicine (2023) Vol. 4: 91-97. DOI: http://dx.doi.org/10.23977/medsc.2023.040414.

REFERENCES

[1] GBD 2015 Mortality and Causes of Death Collaborators. Global, regional, and national life expectancy, all-cause mortality, andcausespecific mortality for 249 causes of Chin J Clin Healthc, 2020, Vol. 23, No. 3 -293- death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015[J]. Lancet, 2016, 388(10053):1459-1544. 
[2] Wang CJ, Li ZX, Gu HQ, et al. China Stroke Report 2019(Chinese version)(1)[J]. China Stroke Journal, 2020, 15(10):1037-1043. 
[3] Hu S. L., Wang J., Cheng C., et al. Epidemiological trend analysis of chronic diseases among Chinese residents[J]. Chinese Journal of Clinical Health Care, 2020, 23(03):289-294. 
[4] Osuga H, Hakin AM. Relevance of interstitial glutamate to selective vulnerability in focal cerebral ischemia [J]. Cereb Bliood Flow Metab, 1994, 14(2):343. 
[5] Ma K, Guo Jj, Wang G, et al. Toll-Like receptor 2-mediated autophagy promotes microglial celldeath by modulating the microglial M1/M2 phenotype[J]. Inflammation, 2020, 43(2):701-711. 
[6] He Jiancheng. Delayed neuronal injury and apoptosis after cerebral ischemia[J]. Shaanxi Medical Journal, 2003, 32(10):911-913. 
[7] Sun Y, Liu W Z, Liu T, et al. Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis[J]. Journal of Receptor and Signal Transduction Research, 2015, 35(6):1-5. 
[8] Maddahi A, Kruse L S, Chen Q W, et al. The role of tumor necrosis factor-α and TNF-αreceptors in cerebral arteries following cerebral ischemia in rat[J]. Journal of Neuroinflammation, 2011, 8(1):1-13. 
[9] Maddahi A, Edvinsson L. Cerebral ischemia induces microvascular pro-inflammatory cytokine expression via the MEK/ERK pathway [J]. Journal of Neuroinflammation, 2010, 7(1):14. 
[10] Wang Zhuo, Zhou Jin, Zeng Jumei, et al. Study on the protective effect and mechanism of sodium ferulate on astrocyte injury caused by oxygen glucose deprivation[J]. Chinese Pharmacology and Clinical, 2017, 33(5):26-30. 
[11] Xue Z F, Guo Y L, Zhang S, et al. Beta-asarone attenuates amyloid beta-induced autophagy via Akt /mTOR pathway in PC12 cells[J]. European Journal of Pharmacology, 2014, 741:195-204. 
[12] Perdigoto C, Bardin A. Sending the right signal: notch and stem cells [J]. Biochimica et Biophysica Acta(BBA)-General Subjects, 2013, 1830(2):2307-2322. 
[13] Colombo E, Farina C. Astrocytes: key regulators of neuroinflammation [J]. Trends in Immunology, 2016, 37(9): 608-620. 
[14] Ten B, Bolk J, Thar T, et al. Multiple sclerosis is linked to MAPKERK overactivity in microglia [J]. Journal of Molecular Medicine, 2021, 99(8): 1033-1042. 
[15] Fang JY, Richardson BC. The MAPK signalling pathways and colorectal cancer[J]. Lancet Oncol, 2005, 6(5): 322-327. 
[16] Zhao W. Effect of P42/P44 MAPK signaling pathway on the expression of HIF-1α and VEGF in RPE cells under hypoxia and serum stimulation [D]. Xi'an: Fourth Military Medical University, 2005. 
[17] Chen B, Zhang F, Li QY, et al. Protective Effect of Ad-VEGF-Bone Mesenchymal Stem Cells on Cerebral Infarction. Turkish neurosurgery 2016, 26:8-15. 
[18] Takasawa K, Kitagawa K, Yagita Y, et al. Increased proliferation of neural progenitor cells but reduced survival of newborn cells in the contralateral hippocampus after focal cerebral ischemia in rats[J]. Journal of Cerebral Blood Flow & Metabolism, 2002, 22(3):299-307. 
[19] Ke, Xj., Zhang, Jj. Changes in HIF-1α, VEGF, NGF and BDNF levels in cerebrospinal fluid and their relationship with cognitive impairment in patients with cerebral infarction[J]. Huazhong Univ. Sci. Technol [Med. Sci. ], 2013, 33, 433-437. 
[20] Yano A, Shingo T, Takeuchi A, et al. Encapsulated vascular endothelial growth factor secreting cellgraftshave neuro-protective and angiogenic effectsonfocalcerebral ischemia[J]. J Neurosurg, 2005, 103(1):104-114. 
[21] CM Engelhardt, K Bundschu, M Messerschmitt, et al. Expression and subcellular localization of Spred proteins in mouse and human tissues[J]. Histochem Cell Biol, 2004, 122(6):527-538. 
[22] Wakioka T, Sasaki A, Kato R, et al. Spred1 is a Sprouty-related suppressor of Ras signalling [J]. Nature, 2001, 412(6847):647-51. 
[23] Yoshida T, Hisamoto T, Akiba J, et al. Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors[J]. Oncogene, 2006, 25:6056-66. 
[24] Shusheng Wang, Arin B. Aurora, Brett A. Johnson, et al. The endothelial specific microRNA miR-126 governs vascular integrity and angiogenesis[J]. Cell, 2008, 15:261-271. 
[25] DA Silva, N. D., Jr., Fernandes, T., Soci, U. P., et al. Swimming training in rats increases cardiac MicroRNA-126 expression and angiogenesis. Med. Sci. Sports Exerc, 2012, 44, 1453-1462. 
[26] Qu M., Pan J., Wang L., et al. MicroRNA-126 Regulates Angiogenesis and Neurogenesis in a Mouse Model of Focal Cerebral Ischemia[J]. Mol. Ther. Nucleic Acids, 2019, 16:15-25. 
[27] Jansen F, Yang X, Hoelscher M, et al. Endothelial microParticle-mediated transfer of MicroRNA-126 Promotes vascuLar endothelial cell rePair via SPRED1 and is abrogated in glucose-damaged endothelial microParticles[J]. CircuLation, 2013, 128(18):2026-38.

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