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  4. Vol 4, Issue 4, 2023

The Pathway in Acute Ischemic Stroke: A Review

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DOI: 10.23977/medsc.2023.040414 | Downloads: 14 | Views: 379

Author(s)

Yu Quanyi 1, Lin Hai 1

Affiliation(s)

1 Shaanxi University of Traditional Chinese Medicine, Xianyang, China

Corresponding Author

Lin Hai

ABSTRACT

Ischemic stroke is characterized by sudden loss of blood flow to specific regions of the brain and is a major cause of permanent disability and one of the leading causes of death worldwide. Sprouty-related EVH1 structural domain containing protein 1 (Spred1) is a recognized physiological inhibitor of the Ras/Raf-1/ERK pathway, and it has been shown that inhibition of Spred1 gene expression in ischemic mice contributes to cerebral angiogenesis and neurogenesis and further improves behavioral recovery through activation of the threonine kinase (AKT) and extracellular signal-related kinase (ERK) signaling pathways. We discuss the role of Spred1/ERK/VEGF signaling pathway activation in acute ischemic stroke, providing a positive panorama and suggesting that Spred1, vascular endothelial growth factor (VEGF) targets may be a promising pharmacological strategy for the treatment of ischemic stroke patients in the near future.

KEYWORDS

Acute ischemic stroke; Spred1; VEGF

CITE THIS PAPER

Yu Quanyi, Lin Hai, The Pathway in Acute Ischemic Stroke: A Review. MEDS Clinical Medicine (2023) Vol. 4: 91-97. DOI: http://dx.doi.org/10.23977/medsc.2023.040414.

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