Author(s)

Yulong Zhang ¹

Affiliation(s)

¹ China Pharmaceutical University, Nanjing, Jiangsu, 300222, China

Corresponding Author

Yulong Zhang

ABSTRACT

Drug permeability is an important factor determining the effectiveness and safety of drug treatment. In the early stage of new drug research and development, testing drug permeability can improve research and development efficiency and reduce research and development costs. Because of its advantages such as rapidity and simplicity, drug permeability has gradually attracted attention. This paper introduces the methods of two-phase distribution, chromatography, capillary electrophoresis, optical sensor and parallel artificial membrane permeation test at home and abroad in recent years.

KEYWORDS

New drug screening; Drug permeability; In vitro evaluation method; progress

CITE THIS PAPER

Yulong Zhang, Evaluation strategy of drug permeability in new drug discovery and development stage. MEDS Clinical Medicine (2023) Vol. 4: 78-83. DOI: http://dx.doi.org/10.23977/medsc.2023.040412.

REFERENCES

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[2] Tu Ketao, Chen Zhiying. Research progress in mechanism of increased blood-brain barrier permeability and drug treatment after intracerebral hemorrhage [J]. Chinese Journal of Practical Neurology, 2022, 25 (04): 508-512
[3] Li Wenqian, Han Jingjing, Zhang Xian, Xu Runze, Yang Jin. Evaluation strategy of drug permeability at the stage of new drug discovery and development [J]. Journal of Pharmacy, 2021, 56 (05): 1279-1285
[4] Ding Yidan, Li Wenbin, Wang Rong, Zhang Jianchun. Research progress of the effect of high altitude hypoxia on blood-brain barrier structure and drug permeability [J]. Journal of Zhejiang University (Medical Edition), 2019, 48 (06): 668-673
[5] Wu Yanqing, Cao Qingqing, Zhang Ting, Zhai Yu, Li Wenping, Yang Jin. Effects of 16 marketed drugs with P-gp inhibition on oral bioavailability and brain permeability of gefitinib [J]. Journal of China Pharmaceutical University, 2019, 50 (02): 206-212
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