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Research on Risk Factors Affecting Sepsis Outcomes

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DOI: 10.23977/medsc.2023.040401 | Downloads: 13 | Views: 513


Gaojie Wang 1, Yue Zhang 1, Binyu He 1, Xuanguo Zhang 2


1 Shaanxi University of Chinese Medicine, Xianyang, 712046, China
2 Intensive Care Unit, Shaanxi Traditional Chinese Medicine Hospital, Xi'an, 710003, China

Corresponding Author

Xuanguo Zhang


Sepsis is one of the diseases with a highest mortality rates in the world. The Sepsis 3.0 consensus places more emphasis on host response to infection, and the concept of "heterogeneity" has been introduced in recent years in understanding sepsis. Therefore, more and more scholars began to pay more attention to the patients themselves, trying to find risk factors for adverse sepsis outcomes, so as to optimize clinical treatment plans and improve patient outcomes. This coincides with the concept of Traditional Chinese Medicine, which is an indispensable part of world medicine, and if the risk factors affecting sepsis outcomes are discussed from the perspective of integrated Traditional Chinese and Western medicine, it will be conducive to a better understanding of sepsis, thereby helping to optimize the individualized treatment of sepsis.


Sepsis, integrated Traditional Chinese and Western medicine, risk factors, heterogeneity


Gaojie Wang, Yue Zhang, Binyu He, Xuanguo Zhang, Research on Risk Factors Affecting Sepsis Outcomes. MEDS Clinical Medicine (2023) Vol. 4: 1-7. DOI:


[1] Fleischmann C, Scherag A, Adhikari NK, et al; International Forum of Acute Care Trialists. Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations. Am J Respir Crit Care Med. 2016 Feb 1; 193(3): 259-72. 
[2] Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016 Feb 23; 315(8): 801-10.
[3] Xie J, Wang H, Kang Y, et al; CHinese Epidemiological Study of Sepsis (CHESS) Study Investigators. The Epidemiology of Sepsis in Chinese ICUs: A National Cross-Sectional Survey. Crit Care Med. 2020 Mar; 48(3): e209-e218.
[4] Chen YJ, Chen FL, Chen JH, et al. Epidemiology of sepsis in Taiwan. Medicine (Baltimore). 2019 May; 98(20): e15725. 
[5] Iskander KN, Osuchowski MF, Stearns-Kurosawa DJ, et al. Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding. Physiol Rev. 2013 Jul; 93(3): 1247-88. 
[6] Caraballo C, Jaimes F. Organ Dysfunction in Sepsis: An Ominous Trajectory from Infection to Death. Yale J Biol Med. 2019 Dec 20; 92(4): 629-640. 
[7] Martin GS, Mannino DM, Moss M. The effect of age on the development and outcome of adult sepsis. Crit Care Med. 2006 Jan; 34(1): 15-21.
[8] Dreiher J, Almog Y, Sprung CL, et al; SEPSIS-ISR Group. Temporal trends in patient characteristics and survival of intensive care admissions with sepsis: a multicenter analysis*. Crit Care Med. 2012 Mar; 40(3): 855-60.
[9] Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet. 2020 Jan 18; 395(10219): 200-211.
[10] Dong Y, Basmaci R, Titomanlio L, et al. Neonatal sepsis: within and beyond China. Chin Med J (Engl). 2020 Sep 20; 133(18): 2219-2228.
[11] Collins A, Weitkamp JH, Wynn JL. Why are preterm newborns at increased risk of infection? Arch Dis Child Fetal Neonatal Ed. 2018 Jul; 103(4): F391-F394. 
[12] Castle SC, Uyemura K, Fulop T, et al. Host resistance and immune responses in advanced age. Clin Geriatr Med. 2007 Aug; 23(3): 463-79.
[13] Rowe TA, McKoy JM. Sepsis in Older Adults. Infect Dis Clin North Am. 2017 Dec; 31(4): 731-742. 
[14] Pai S, Enoch DA, Aliyu SH. Bacteremia in children: epidemiology, clinical diagnosis and antibiotic treatment. Expert Rev Anti Infect Ther. 2015; 13(9): 1073-88. 
[15] Xiao H, Siddiqui J, Remick DG. Mechanisms of mortality in early and late sepsis. Infect Immun. 2006 Sep; 74(9): 5227-35.
[16] Osuchowski MF, Welch K, Yang H, et al. Chronic sepsis mortality characterized by an individualized inflammatory response. J Immunol. 2007 Jul 1; 179(1): 623-30.
[17] Kushimoto S, Abe T, Ogura H, et al; JAAM Focused Outcome Research on Emergency Care for Acute respiratory distress syndrome, Sepsis and Trauma (FORECAST) Group. Impact of Body Temperature Abnormalities on the Implementation of Sepsis Bundles and Outcomes in Patients with Severe Sepsis: A Retrospective Sub-Analysis of the Focused Outcome Research on Emergency Care for Acute Respiratory Distress Syndrome, Sepsis and Trauma Study. Crit Care Med. 2019 May; 47(5): 691-699.
[18] Park S, Jeon K, Oh DK, et al; Korean Sepsis Alliance (KSA) Study Group. Normothermia in Patients with Sepsis Who Present to Emergency Departments Is Associated with Low Compliance with Sepsis Bundles and Increased In-Hospital Mortality Rate. Crit Care Med. 2020 Oct; 48(10): 1462-1470. 
[19] Lee BH, Inui D, Suh GY, et al; Fever and Antipyretic in Critically ill patients Evaluation (FACE) Study Group. Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi-centered prospective observational study. Crit Care. 2012 Feb 28; 16(1): R33. 
[20] Shimazui T, Nakada TA, Walley KR,et al; JAAM FORECAST Group. Significance of body temperature in elderly patients with sepsis. Crit Care. 2020 Jun 30; 24(1): 387. 
[21] Garami A, Steiner AA, Romanovsky AA. Fever and hypothermia in systemic inflammation. Handb Clin Neurol. 2018; 157: 565-597.
[22] Dickson RP, Singer BH, Newstead MW, et al. Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome. Nat Microbiol. 2016 Jul 18; 1(10):16113.
[23] Vincent JL, Sakr Y, Sprung CL, et al; Sepsis Occurrence in Acutely Ill Patients Investigators. Sepsis in European intensive care units: results of the SOAP study. Crit Care Med. 2006 Feb; 34(2):344-53. 
[24] Rhee C, Jones TM, Hamad Y, et al; Centers for Disease Control and Prevention (CDC) Prevention Epicenters Program. Prevalence, Underlying Causes, and Preventability of Sepsis-Associated Mortality in US Acute Care Hospitals. JAMA Netw Open. 2019 Feb 1; 2(2):e187571. 
[25] Zhou X, Liao Y. Gut-Lung Crosstalk in Sepsis-Induced Acute Lung Injury. Front Microbiol. 2021 Dec 23; 12: 779620. 
[26] Jones RM, Neish AS. Gut Microbiota in Intestinal and Liver Disease. Annu Rev Pathol. 2021 Jan 24; 16: 251-275. 
[27] Otani S, Coopersmith CM. Gut integrity in critical illness. J Intensive Care. 2019 Mar 20; 7: 17.
[28] Bagshaw SM, Uchino S, Bellomo R, et al; Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators. Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes. Clin J Am Soc Nephrol. 2007 May;2(3):431-9. 
[29] Uchino S, Kellum JA, Bellomo R, et al; Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA. 2005 Aug 17; 294(7): 813-8.
[30] Chua HR, Wong WK, Ong VH, et al. Extended Mortality and Chronic Kidney Disease after Septic Acute Kidney Injury. J Intensive Care Med. 2020 Jun; 35(6):527-535.
[31] Suh SH, Kim CS, Choi JS, et al. Acute kidney injury in patients with sepsis and septic shock: risk factors and clinical outcomes. Yonsei Med J. 2013 Jul; 54(4):965-72. 
[32] Poukkanen M, Vaara ST, Pettilä V, et al; FINNAKI study group. Acute kidney injury in patients with severe sepsis in Finnish Intensive Care Units. Acta Anaesthesiol Scand. 2013 Aug; 57(7):863-72. 
[33] Ma S, Evans RG, Iguchi N, et al. Sepsis-induced acute kidney injury: A disease of the microcirculation. Microcirculation. 2019 Feb; 26(2):e12483. 
[34] Poston JT, Koyner JL. Sepsis associated acute kidney injury. BMJ. 2019 Jan 9; 364:k4891.
[35] Brun-Buisson C, Meshaka P, Pinton P, et al; EPISEPSIS Study Group. EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units. Intensive Care Med. 2004 Apr; 30(4):580-8. 
[36] Simonetto DA, Piccolo Serafim L, Gallo de Moraes A,et al. Management of Sepsis in Patients With Cirrhosis: Current Evidence and Practical Approach. Hepatology. 2019 Jul;70(1):418-428. 
[37] Strnad P, Tacke F, Koch A, et al. Liver - guardian, modifier and target of sepsis. Nat Rev Gastroenterol Hepatol. 2017 Jan; 14(1):55-66. 
[38] Philips CA, Sarin SK. Sepsis in cirrhosis: emerging concepts in pathogenesis, diagnosis and management. Hepatol Int. 2016 Nov; 10(6):871-882.
[39] Arfaras-Melainis A, Polyzogopoulou E, Triposkiadis F, et al. Heart failure and sepsis: practical recommendations for the optimal management. Heart Fail Rev. 2020 Mar; 25(2):183-194.
[40] Sanfilippo F, Corredor C, Fletcher N, et al. Diastolic dysfunction and mortality in septic patients: a systematic review and meta-analysis. Intensive Care Med. 2015 Jun; 41(6):1004-13.
[41] Frencken JF, Donker DW, Spitoni C, et al. Myocardial Injury in Patients with Sepsis and Its Association with Long-Term Outcome. Circ Cardiovasc Qual Outcomes. 2018 Feb; 11(2):e004040. 
[42] Liu YC, Yu MM, Shou ST, et al. Sepsis-Induced Cardiomyopathy: Mechanisms and Treatments. Front Immunol. 2017 Aug 24; 8: 1021.
[43] Elkind MSV, Boehme AK, Smith CJ, et al. Infection as a Stroke Risk Factor and Determinant of Outcome After Stroke. Stroke. 2020 Oct; 51(10):3156-3168. 
[44] Boehme AK, Ranawat P, Luna J, et al. Risk of Acute Stroke after Hospitalization for Sepsis: A Case-Crossover Study. Stroke. 2017 Mar; 48(3):574-580.
[45] Smith CJ, Kishore AK, Vail A, et al. Diagnosis of Stroke-Associated Pneumonia: Recommendations From the Pneumonia in Stroke Consensus Group. Stroke. 2015 Aug; 46(8):2335-40. 
[46] Losonczy G, Kriston T, Szabó A, et al. Male gender predisposes to development of endotoxic shock in the rat. Cardiovasc Res. 2000 Jul;47(1):183-91. 
[47] Jarrar D, Wang P, Cioffi WG, et al. The female reproductive cycle is an important variable in the response to trauma-hemorrhage. Am J Physiol Heart Circ Physiol. 2000 Sep; 279(3):H1015-21. 
[48] Angele MK, Pratschke S, Hubbard WJ, et al. Gender differences in sepsis: cardiovascular and immunological aspects. Virulence. 2014 Jan 1; 5(1):12-9. 

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