Author(s)

Yu Wang ^1,2, Kejun Du ^1,2

Affiliation(s)

¹ School of Public Health, Shaanxi University of Chinese Medicine, Xi'an, Shaanxi, 712046 China
² Department of Occupational and Environmental Health, the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Faculty of Preventive Medicine, Fourth Military Medical University, Xi'an, Shaanxi, 710032 China

Corresponding Author

Kejun Du

ABSTRACT

Lead mainly accumulates in hippocampus. A large number of research results show that the toxic effect of lead accumulation in hippocampus can cause changes in the structure and function of hippocampus itself, which in turn leads to the decline of learning and memory ability and cognitive abnormality. The time interval between action potential reaching nerve endings and subsequent vesicle fusion is very short, which can make protein phosphorylation dephosphorylation play a direct and acute role in single-round vesicle exocytosis. Synapse formation is a dynamic process, which involves the stability of neural network and the recruitment of pre-synaptic and post-synaptic specific proteins. After fusion with vesicles, it is released into synaptic cleft, in which glutamate is transported from presynaptic to synaptic endings as a glutamate transporter, and then combined with postsynaptic membrane receptors to exert synaptic effect. In this paper, the mechanism of synaptic vesicles release from lead-exposed hippocampal neurons was studied by cRNA, and the possible mechanism of synaptic vesicles release from lead-exposed hippocampal neurons was discussed by observing the changes of ultrastructure of neurons, organelles and morphological parameters of synapses in hippocampus.

KEYWORDS

cRNA, Lead exposure, Hippocampal neurons, Mechanism of synaptic vesicles's release

CITE THIS PAPER

Yu Wang, Kejun Du, Mechanism of cRNA-Induced Synaptic Vesicles Release from Lead-Exposed Hippocampal Neurons. MEDS Clinical Medicine (2023) Vol. 4: 125-129. DOI: http://dx.doi.org/10.23977/medsc.2023.040218.

REFERENCES

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