Research Progress on Helicobacter Pylori Infection and Autoimmune Thyroid Disease

Ziteng Wang; Hong Liu; Huanhuan Xiong; Licun Zhu; Wentao Tan; Pengfei Zhang; Mengqi Zhao

doi:10.23977/medsc.2023.040212

Research Progress on Helicobacter Pylori Infection and Autoimmune Thyroid Disease

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DOI: 10.23977/medsc.2023.040212 | Downloads: 28 | Views: 563

Author(s)

Ziteng Wang ¹, Hong Liu ¹, Huanhuan Xiong ¹, Licun Zhu ², Wentao Tan ¹, Pengfei Zhang ¹, Mengqi Zhao ³

Affiliation(s)

¹ Department of Gastroenterology, Beijing Shijitan Hospital, Capital Medical University, No.10, Tieyi Road, Beijing, China
² Department of Gastroenterology, Shougang Hospital, Peking University, No.9, Jinyuanzhuang Road, Beijing, China
³ Department of Internal Medicine-Cardiovascular, Beijing Shijitan Hospital, Capital Medical University, No.10, Tieyi Road, Beijing, China

Corresponding Author

Hong Liu

ABSTRACT

In recent years, more and more studies have focused on the extra-digestive manifestations of Helicobacter pylori, and thyroid disease is a current hot spot. It has been confirmed that changes in the structure and composition of intestinal flora are related to the occurrence and development of autoimmune thyroid disease (AITD). When the intestinal flora is unbalanced, Helicobacter pylori colonizes the body through the damaged gut and releases special proteins that have similar amino acid sequences to thyroid antibodies. These proteins also destroy the metabolism of the body through molecular simulation and other mechanisms, attack the autoimmune system, especially the thyroid system, and ultimately lead to AITD. Therefore, Helicobacter pylori may play an important role in the pathogenesis of autoimmune thyroid disease, and this evidence may provide new ways to treat autoimmune thyroid disease.

KEYWORDS

Autoimmune thyroid disease; Intestinal flora; Autoimmune diseases; Hashimoto's thyroiditis; Helicobacter pylori

CITE THIS PAPER

Ziteng Wang, Hong Liu, Huanhuan Xiong, Licun Zhu, Wentao Tan, Pengfei Zhang, Mengqi Zhao, Research Progress on Helicobacter Pylori Infection and Autoimmune Thyroid Disease. MEDS Clinical Medicine (2023) Vol. 4: 75-82. DOI: http://dx.doi.org/10.23977/medsc.2023.040212.

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Research Progress on Helicobacter Pylori Infection and Autoimmune Thyroid Disease

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