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Efficacy of Amlodipine Combined with Telmisartan or Amiloride in Treating Primary Hypertension: A Meta-Analysis

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DOI: 10.23977/medsc.2023.040204 | Downloads: 21 | Views: 376

Author(s)

Tengfei Han 1, Huazhong Song 1, Caiyan An 2

Affiliation(s)

1 Inner Mongolia Medical University, Xinhua Street, Huimin District, Hohhot, Inner Mongolia Autonomous Region, China
2 Hohhot No.1 Hospital, Zhaojun Road Street, Yuquan District, Hohhot, Inner Mongolia Autonomous Region, China

Corresponding Author

Caiyan An

ABSTRACT

Objective is to systematically analyze the efficacy of Amlodipine combined with Telmisartan or Amiloride in the treatment of primary hypertension. Methods about computer and manual retrieval, seven databases of CNKI, VIP, Wanfang, Baidu scholar, China biomedical literature database (CBM), PubMed and SinoMed, and supplemented by other ways, the randomized controlled trials of Amlodipine combined with Telmisartan or Amiloride were screened. With Review Manger 5. 3 software for Meta-analysis. Results: 9 needed literature were finally selected, with a total of 443 patients. Meta-analysis showed that Amlodipine combined with Telmisartan or Amiloride have a positive effect on primary hypertension, and there is no significant difference between the two medication methods under different medication periods (DBP 82. 7 ± 6. 5, 95% CI [- 0. 80, 0. 75], P > 0. 05, SBP 131. 1 ± 9. 1, 95% CI [- 0. 66, 1. 65], P > 0. 05). Conclusion there is no difference in the treatment of Amlodipine combined with Telmisartan or Amlodipine combined with Amiloride for 4-12 months, but different medication time of studies show significant heterogeneity (I2 > 50%). Considering the quality and quantity of the included literature, we believe that the research conclusions still need to be confirmed by more clinical reference studies. 

KEYWORDS

Amlodipine, Telmisartan, Amiloride, Primary hypertension, Combined medication

CITE THIS PAPER

Tengfei Han, Huazhong Song, Caiyan An, Efficacy of Amlodipine Combined with Telmisartan or Amiloride in Treating Primary Hypertension: A Meta-Analysis. MEDS Clinical Medicine (2023) Vol. 4: 21-29. DOI: http://dx.doi.org/10.23977/medsc.2023.040204.

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