Education, Science, Technology, Innovation and Life
Open Access
Sign In
  1. Home
  2. Journals
  3. MEDS Clinical Medicine
  4. Vol 4, Issue 2, 2023

Efficacy of Amlodipine Combined with Telmisartan or Amiloride in Treating Primary Hypertension: A Meta-Analysis

Download as PDF

DOI: 10.23977/medsc.2023.040204 | Downloads: 41 | Views: 768

Author(s)

Tengfei Han 1, Huazhong Song 1, Caiyan An 2

Affiliation(s)

1 Inner Mongolia Medical University, Xinhua Street, Huimin District, Hohhot, Inner Mongolia Autonomous Region, China
2 Hohhot No.1 Hospital, Zhaojun Road Street, Yuquan District, Hohhot, Inner Mongolia Autonomous Region, China

Corresponding Author

Caiyan An

ABSTRACT

Objective is to systematically analyze the efficacy of Amlodipine combined with Telmisartan or Amiloride in the treatment of primary hypertension. Methods about computer and manual retrieval, seven databases of CNKI, VIP, Wanfang, Baidu scholar, China biomedical literature database (CBM), PubMed and SinoMed, and supplemented by other ways, the randomized controlled trials of Amlodipine combined with Telmisartan or Amiloride were screened. With Review Manger 5. 3 software for Meta-analysis. Results: 9 needed literature were finally selected, with a total of 443 patients. Meta-analysis showed that Amlodipine combined with Telmisartan or Amiloride have a positive effect on primary hypertension, and there is no significant difference between the two medication methods under different medication periods (DBP 82. 7 ± 6. 5, 95% CI [- 0. 80, 0. 75], P > 0. 05, SBP 131. 1 ± 9. 1, 95% CI [- 0. 66, 1. 65], P > 0. 05). Conclusion there is no difference in the treatment of Amlodipine combined with Telmisartan or Amlodipine combined with Amiloride for 4-12 months, but different medication time of studies show significant heterogeneity (I2 > 50%). Considering the quality and quantity of the included literature, we believe that the research conclusions still need to be confirmed by more clinical reference studies. 

KEYWORDS

Amlodipine, Telmisartan, Amiloride, Primary hypertension, Combined medication

CITE THIS PAPER

Tengfei Han, Huazhong Song, Caiyan An, Efficacy of Amlodipine Combined with Telmisartan or Amiloride in Treating Primary Hypertension: A Meta-Analysis. MEDS Clinical Medicine (2023) Vol. 4: 21-29. DOI: http://dx.doi.org/10.23977/medsc.2023.040204.

REFERENCES

[1] Dahlöf B, Sever PS, Poulter NR, Wedel H, Beevers DG, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT et al. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial J The Lancet. 2005, 366(9489). 
[2] I BJ, R DB, A CJ, L PS, K WP, Jan B, L MK, T OS, S SL, John S: Fasting glucose levels and incident diabetes mellitus in older nondiabetic adults randomized to receive 3 different classes of antihypertensive treatment: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). J Archives of internal medicine. 2006, 166(20). 
[3] Zeng Yongjing, Luo Hong. Effect of combination therapy in the treatment of hypertension in the elderly. Shenzhen Journal of Integrated Traditional Chinese and Western Medicine, 2021, 31(15):176-177. 
[4] Niu HY. Comparison of amlodipine combined with compound amiloride or telmisartan in the treatment of essential hypertension J Cardio-Cerebrovascular Disease of Integrated Traditional Chinese and Western Medicine, 2011, 9(06):672-674. 
[5] Jing Xiaojuan. Effect of amlodipine combined with telmisartan or compound amiloride hydrochloride on blood pressure and left ventricular hypertrophy in patients with hypertension and its relationship with serum leptin and adiponectin. M. s. The Fourth Military Medical University; 2009. 
[6] Shu Ying, Zhang Yanmei, Chen Fuqiong, Tang Jiarong, Wang Daowen. Comparison of efficacy and safety of amlodipine combined with telmisartan and compound amiloride. J Pharmacoepidemiology, 2011, 20(06):275-278
[7] Zhu Min, Liu Fuyuan, Yan Ji, Yan Guang. Comparison of the efficacy of amlodipine combined with telmisartan combined with amlodipine combined with amlodipine combined with amiloride in the treatment of essential hypertension J Anhui Med, 2010, 31(10):1144-1146. 
[8] He X J, He X J. Comparison of amlodipine combined with telmisartan and amlodipine combined with amiloride in the treatment of essential hypertension J Med Guide, 2011, 9(22):78-79. 
[9] Jia Ying. Clinical efficacy evaluation and influencing factors analysis of amlodipine based combined antihypertensive therapy. M. s. Central South University; 2010. 
[10] Xie Mu, Zhuang Jie, Sun Hong. Cost-effectiveness analysis of two combined antihypertensive regimens %J Straits Pharmacy, 2010, 22(03):205-206. (in Chinese)
[11] Chang Lili, Guo Jing, Li Yan. Efficacy of amlodipine combined with telmisartan in the treatment of essential hypertension and its effect on vascular endothelial function. J Med Tribune, 2021, 42(23):110-113. 
[12] Chen Jicai. Clinical analysis of amlodipine combined with telmisartan in the treatment of essential hypertension. J Chinese Medicine Guide, 2017, 15(34):49. 
[13] Man L, Qun WZ, Lu Z, Hao Z, Wu LD, Geng ZM. Burden of Cirrhosis and Other Chronic Liver Diseases Caused by Specific Etiologies in China, 1990-2016:Findings from the Global Burden of Disease Study 2016 J Biomedical and Environmental Sciences. 2020, 33(01):1-10. 
[14] T MK, Andrei S, Jiang H. The global epidemiology of hypertension. J Nature reviews. Nephrology. 2020, 16(4). 

Subscription
E-Mail Alert
Most popular papers
Call for Special Issue
Publication Ethics & OA Statement
Plagiarism Policy
Contact Us
Downloads: 6878
Visits: 334274

Sponsors, Associates, and Links

All published work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2016 - 2031 Clausius Scientific Press Inc. All Rights Reserved.