Education, Science, Technology, Innovation and Life
Open Access
Sign In

Research status and progress of bone marrow mesenchymal stem cells for osteonecrosis of femoral head

Download as PDF

DOI: 10.23977/medsc.2023.040103 | Downloads: 8 | Views: 508

Author(s)

Peng Xu 1, Miao Tan 1, Mingming Wang 1, Yan Cheng 2

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, 712046, China
2 Shaanxi Hospital of Traditional Chinese Medicine, Xi'an, 710003, China

Corresponding Author

Yan Cheng

ABSTRACT

Osteonecrosis of femoral head (ONFH) is a progressive, destructive disorder with no targeted treatment currently available. The etiology of this disease is complex and the pathogenesis is not clear. The main clinical manifestations are hip pain and mobility dysfunction, which threatens human health to a large extent. If not timely intervention and treatment in the early and middle stages of ONFH, femoral head deformation and even collapse are easy to occur, seriously affecting the prognosis of patients. Therefore, early identification and treatment of ONFH is very important. With the development and maturity of regenerative medicine and tissue engineering technologies, studies have shown that Bone marrow mesenchymal stem cells (BMSCs) combined with cardiac decompression, autologous bone transplantation, arterial interventional therapy, and tissue engineering techniques, it has certain curative effect on early and middle stage ONFH. This paper mainly discusses the research status and progress of BMSCs in the treatment of ONFH, in order to provide theoretical basis for the treatment of ONFH with BMSCs.

KEYWORDS

Bone marrow mesenchymal stem cells; osteonecrosis of femoral head; cardiac decompression; autogenous bone grafting; arterial interventional therapy; tissue engineering technology; summary

CITE THIS PAPER

Peng Xu, Miao Tan, Mingming Wang, Yan Cheng, Research status and progress of bone marrow mesenchymal stem cells for osteonecrosis of femoral head. MEDS Clinical Medicine (2023) Vol. 4: 15-21. DOI: http://dx.doi.org/10.23977/medsc.2023.040103.

REFERENCES

[1] Ma HY, Ma N, Liu YF, et al. Core Decompression with Local Administration of Zoledronate and Enriched Bone Marrow Mononuclear Cells for Treatment of Non-Traumatic Osteonecrosis of Femoral Head. Orthop Surg. 2021; 13(6):1843-1852.
[2] Jin Y, Zhu HX, Wei BF. Reduced serum and local LncRNA MALAT1 expressions are linked with disease severity in patients with non-traumatic osteonecrosis of the femoral head. Technol Health Care. 2021; 29(3):479-488.
[3] Zhao D, Zhang F, Wang B, et al. Guidelines for clinical diagnosis and treatment of osteonecrosis of the femoral head in adults (2019 version). J Orthop Translat. 2020; 21: 100-110. 
[4] Microsurgery Department of the Orthopedics Branch of the Chinese Medical Doctor Association; Group from the Osteonecrosis and Bone Defect Branch of the Chinese Association of Reparative and Reconstructive Surgery; Microsurgery and Reconstructive Surgery Group of the Orthopedics Branch of the Chinese Medical Association. Chinese Guideline for the Diagnosis and Treatment of Osteonecrosis of the Femoral Head in Adults. Orthop Surg. 2017; 9(1):3-12. 
[5] Liu N, Zheng C, Wang Q, et al. Treatment of non-traumatic avascular necrosis of the femoral head (Review). Exp Ther Med. 2022; 23(5):321.
[6] Cui Q, Jo WL, Koo KH, et al. ARCO Consensus on the Pathogenesis of Non-traumatic Osteonecrosis of the Femoral Head. J Korean Med Sci. 2021; 36(10):e65. Published 2021 Mar 15. 
[7] Wang C, Wang Y, Meng H Y, et al. Application of bone marrow mesenchymal stem cells to the treatment of osteonecrosis of the femoral head [J]. International Journal of Clinical and Experimental Medicine, 2015, 8(3):3127-3135.
[8] Wen J F, Wei B F. Research progress in osteogenic differentiation of bone marrow mesenchymal stem cells in steroid-induced osteonecrosis of the femoral head [J]. Editorial Board of Medical Journal of Chinese People's Liberation Army, 2020(11).
[9] Li Z, Yang X, Liang S, et al. Imaging Observation of Nano-Artificial Bone in the Repair of the Defect in Osteonecrosis of the Femoral Head[J]. Journal of Nanoscience and Nanotechnology, 2020.
[10] Wang Pengzhi, Li Shenghua. Research progress of bone marrow mesenchymal stem cells in treatment of femoral head necrosis [J]. Clinical of Integrated Traditional Chinese and Western Medicine, 2018, 1:179-182.
[11] Xu Y, Jiang Y, Xia C, et al. Stem cell therapy for osteonecrosis of femoral head: Opportunities and challenges. Regen Ther. 2020; 15: 295-304. Published 2020 Nov 28. 
[12] Zhang C, Su Y, Ding H,et al. Mesenchymal stem cells-derived and siRNAs-encapsulated exosomes inhibit osteonecrosis of the femoral head. J Cell Mol Med. 2020; 24(17):9605-9612. 
[13] Song D, Wu ZS, Xu Q, et al. LRRC17 regulates the bone metabolism of human bone marrow mesenchymal stem cells from patients with idiopathic necrosis of femoral head through Wnt signaling pathways: A preliminary report. Exp Ther Med. 2021; 22(1):666. 
[14] Talmaç MA, Kanar M, Sönmez MM, Özdemir HM, Dırvar F, Tenekecioğlu Y. The Results of Core Decompression Treatment in Avascular Necrosis of the Femoral Head. Sisli Etfal Hastan Tip Bul. 2018; 52(4):249-253. Published 2018 Dec 28.
[15] Zhao D, Liu B, Wang B, et al. Autologous Bone Marrow Mesenchymal Stem Cells Associated with Tantalum Rod Implantation and Vascularized Iliac Grafting for the Treatment of End-Stage Osteonecrosis of the Femoral Head[J]. Biomed Res Int, 2015, 2015:240506.
[16] Peng K, Wang Y, Zhu J, et al. Repair of non-traumatic femoral head necrosis by marrow core decompression with bone grafting and porous tantalum rod implantation. Pak J Med Sci. 2020; 36(6):1392-1396. 
[17] Wang L, Tian X, Li K, et al. Combination use of core decompression for osteonecrosis of the femoral head: A systematic review and meta-analysis using Forest and Funnel Plots. Comput Math Methods Med. 2021; 2021: 1284149. Published 2021 Dec 6.
[18] Wang Z, Sun QM, Zhang FQ, et al. Core decompression combined with autologous bone marrow stem cells versus core decompression alone for patients with osteonecrosis of the femoral head: A meta-analysis. Int J Surg. 2019; 69: 23-31. 
[19] Liu Q, Guo W, Li R, et al. Efficacy of various core decompression techniques versus non-operative treatment for osteonecrosis of the femoral head: a systemic review and network meta-analysis of randomized controlled trials. BMC Musculoskelet Disord. 2021; 22(1):948. Published 2021 Nov 15.
[20] Liu Jiangfeng. Core decompression combined with autologous bone marrow mesenchymal stem cell transplantation for treatment of femoral head necrosis [J]. Chin J Tissue Engineering Research, 2019, 29: 4599-4604.
[21] Goto K, Aoyama T, Toguchida J, et al. Ten-year results of mesenchymal stromal cell transplantation augmented with vascularised bone grafts for advanced osteonecrosis of the femoral head. J Orthop. 2021; 26:67-71. Published 2021 Jul 13. 
[22] Kang JS, Moon KH, Kim BS, et al. Clinical results of auto-iliac cancellous bone grafts combined with implantation of autologous bone marrow cells for osteonecrosis of the femoral head: a minimum 5-year follow-up. Yonsei Med J. 2013; 54(2):510-515. 
[23] Liu Pei, Liu Guojie, Ye Ye, et al. Research progress of mesenchymal stem cell transplantation in the treatment of femoral head necrosis [J]. Chinese Journal of Bone and Joint Surgery, 2021, 03:229-234.
[24] Pan J, Ding Q, Lv S, et al. Prognosis after autologous peripheral blood stem cell transplantation for osteonecrosis of the femoral head in the pre-collapse stage: a retrospective cohort study. Stem Cell Res Ther. 2020;11(1):83. Published 2020 Feb 26. 
[25] Mao Q, Jin H, Liao F, et al. The efficacy of targeted intraarterial delivery of concentrated autologous bone marrow containing mononuclear cells in the treatment of osteonecrosis of the femoral head: a five year follow-up study. Bone. 2013; 57(2):509-516. 
[26] Jin H, Xu T, Chen Q, et al. The Fate and Distribution of Autologous Bone Marrow Mesenchymal Stem Cells with Intra-Arterial Infusion in Osteonecrosis of the Femoral Head in Dogs. Stem Cells Int. 2016; 2016: 8616143.
[27] Kang Y, Xu C, Meng L, et al. Exosome-functionalized magnesium-organic framework-based scaffolds with osteogenic, angiogenic and anti-inflammatory properties for accelerated bone regeneration. Bioact Mater. 2022; 18: 26-41. Published 2022 Feb 18. 
[28] Wang T, Wei Wang. Treatment of osteonecrosis of the femoral head with thorough debridement, bone grafting and bone-marrow mononuclear cells implantation [J]. Eur J Orthop Surg Traumatol, 2014, 24(2):197-202.
[29] Maruyama M, Nabeshima A, Pan CC, et al. The effects of a functionally-graded scaffold and bone marrow-derived mononuclear cells on steroid-induced femoral head osteonecrosis. Biomaterials. 2018; 187:39-46. 
[30] Wang G, Li Y, Sun T, et al. BMSC affinity peptide-functionalized β-tricalcium phosphate scaffolds promoting repair of osteonecrosis of the femoral head. J Orthop Surg Res. 2019; 14(1):204. Published 2019 Jul 4.

Downloads: 3870
Visits: 167006

Sponsors, Associates, and Links


All published work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2016 - 2031 Clausius Scientific Press Inc. All Rights Reserved.