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Effect of Prednisolone Therapy on Hand Osteoarthritis Patients with Synovitis

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DOI: 10.23977/medsc.2020.010101 | Downloads: 5 | Views: 1309

Author(s)

Xue Han 1, Jianjun Li 2, Ningning Liu 2

Affiliation(s)

1 Operation room, Binzhou People’s Hospital, Binzhou, Shandong, China, 256600
2 Orthopaedics, Binzhou People’s Hospital, Binzhou, Shandong, China, 256600

Corresponding Author

Xue Han

ABSTRACT

Objective: To study the clinical effect of short-term prednisolone therapy on patients with hand osteoarthritis accompanied by synovitis. Methods: From December 2017 to December 2019, 80 patients with synovitis diagnosed with hand osteoarthritis were randomly divided into 2 groups according to different treatment schemes, 40 cases in each group: Prednisone treatment group (group P: 5 mg/ mL /time/day, 2 ml, oral) and placebo group (group C: 2 mL /time/day, placebo, oral) continued this regimen for 6 weeks. The patients in group P were changed to 5 mg/mL/time/day, and after 1 week of continuous medication, the dosage was changed to 2.5 mg/day and continued to be used for 1 week, and the medication was stopped. Group C changed the placebo dosage according to group P. Observed from the 9th to the 14th week, a total of 6 weeks. The joint swelling, visual analogue score (VAS score), salvage analgesic drug use, joint function score, and serum C-reactive protein (CRP) levels were recorded in both groups. Results: All patients completed the 14-week trial and follow-up. The recorded results are as follows: the VAS scores of the hand bone joints of the two groups were compared with those before treatment (T0). The VAS scores were 6 weeks (T1) and 8 weeks (T2). The pain was relieved, and the difference was statistically significant (P<0.05). After receiving prednisolone treatment, the swelling of the hand joints in group P was reduced at T1 and T2, and the joint function score was decreased at T1 and T2. Serum CRP level was reduced at T1 and T2, the difference was statistically significant (P<0.05). Compared with group C, the pain in group P was reduced at T1 and T2, the degree of joint swelling was reduced at T1 and T2, the joint function score was decreased at T1 and T2, and the serum CRP level was reduced at T1 and T2. The difference was statistically significant (P<0.05); the use of salvage analgesics in group P was 1 and 2 at T1 and T2, respectively, and the use of salvage analgesics in group C was 7 and 12 at T1 and T2, respectively, the difference between the two groups was statistically significant (P<0.05). One case of gastrointestinal discomfort occurred in group C (2.50%); one case of gastrointestinal discomfort occurred in group P(2.50%), two cases of elevated blood glucose(5.00%), and one case of rash(2.50%). There was no significant difference in the occurrence of adverse reactions between the two groups (P>0.05). Conclusion: The short-term treatment of prednisolone can significantly improve the pain symptoms of hand osteoarthritis, reduce the synovitis reaction, and there are no obvious adverse events, which can effectively improve hand joint function.

KEYWORDS

Hand osteoarthritis, Synovitis, Prednisolone

CITE THIS PAPER

Xue Han, Jianjun Li, Ningning Liu, Effect of Prednisolone Therapy on Hand Osteoarthritis Patients with Synovitis. MEDS Clinical Medicine (2020) 1: 1-8. DOI: http://dx.doi.org/10.23977/medsc.2020.010101.

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