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Systematic evaluation and meta-analysis of randomized controlled trial of TCM facial mask in the treatment of acne

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DOI: 10.23977/medcm.2022.040906 | Downloads: 15 | Views: 532

Author(s)

Mengli Geng 1, Yiding Zhao 2, Dan Sun 2

Affiliation(s)

1 Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi, 712046, China
2 Shaanxi Hospital of Traditional Chinese Medicine, Xi'an, Shaanxi, 710003, China

Corresponding Author

Yiding Zhao

ABSTRACT

Objective: To systematically evaluate the clinical efficacy and safety of traditional Chinese medicine masks in the auxiliary treatment of acne, and provide evidence-based reference for clinical practice. Methods: Computer search of PubMed, China Knowledge Network (CNKI), WanFang, VIP (VIP) and other databases, collect randomized controlled trials of traditional Chinese medicine mask alone or in combination with conventional therapies to treat acne, and extract data from clinical studies that meet the inclusion criteria. Cochrane review Handbook 5.1 was used for quality evaluation, and stata 15.1 was used for meta-analysis. Results: A total of 13 articles were included, and a total of 945 patients with acne were included. Meta results showed that the clinical cure rate of acne treated with traditional Chinese medicine mask was significantly higher than that of the control group, which was statistically significant (P=0.000). The RR value and 95% CI were 1.71 ( 1.40, 2.10); Compared with non-TCM facial mask treatment, the total clinical effective RR value and 95% CI for acne treatment with TCM facial mask is 1.22 (1.15, 1.29); TCM facial mask is better than acne comprehensive grading system score (GAGS) The control group, with statistical significance (P=0.000), the estimated SMD point and 95% CI was -0.92 (-1.18, -0.65); there was no statistical difference between the treatment group and the control group in adverse reactions (P=0.344) , RR value and 95% CI were 0.73 (0.38, 1.40). Discussion: Traditional Chinese medicine masks have a definite clinical effect and good safety in the auxiliary treatment of acne. Commonly used Chinese medicines include heat-clearing medicines and blood-activating medicines for removing blood stasis. However, limited by the quality of the included studies, this conclusion still needs more large-sample, multi-center, high-quality RCTs for verification.

KEYWORDS

Acne; traditional Chinese medicine mask; meta-analysis; clinical efficacy

CITE THIS PAPER

Mengli Geng, Yiding Zhao, Dan Sun, Systematic evaluation and meta-analysis of randomized controlled trial of TCM facial mask in the treatment of acne. MEDS Chinese Medicine (2022) Vol. 4: 45-53. DOI: http://dx.doi.org/10.23977/medcm.2022.040906.

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