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Advances in Mesenchymal Stem Cell Derived Exosomes in the Repair Mechanism of Spinal Cord Injury

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DOI: 10.23977/medsc.2022.030801 | Downloads: 12 | Views: 237


Heshan Zhou 1, Longwang Tan 2


1 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
2 Department of Spinal Orthopaedics, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712000, China

Corresponding Author

Longwang Tan


Once a spinal cord injury occurs, it can place a tremendous emotional, physical, and financial burden on the patient and their family. Mesenchymal stem cell transplantation has shown promising efficacy in spinal cord injury, and its paracrine production of exosomes may be the main component exerting therapeutic effects. Exosomes are small vesicles that function similarly to source cells and are capable of participating in a variety of cellular processes. Current studies have demonstrated that MSC-derived exosomes can achieve repair of spinal cord injury by inhibiting the inflammatory response, reducing apoptosis, promoting axonal regeneration, angiogenesis, neuroprotection, and other mechanisms. This paper reviews the mechanism of mesenchymal stem cell-derived exosomes in spinal cord injury, which helps to further explore the feasibility of mesenchymal stem cell-derived exosomes in treating spinal cord injury and provides new methods and strategies for the follow-up study of spinal cord injury.


Mesenchymal Stem Cells, Exosomes, Spinal Cord Injury


Heshan Zhou, Longwang Tan, Advances in Mesenchymal Stem Cell Derived Exosomes in the Repair Mechanism of Spinal Cord Injury . MEDS Clinical Medicine (2022) Vol. 3: 1-12. DOI:


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