Education, Science, Technology, Innovation and Life
Open Access
Sign In
  1. Home
  2. Journals
  3. MEDS Chinese Medicine
  4. Vol 4, Issue 7, 2022

Research Progress of Traditional Chinese Medicine Intervention on TGF-Β/Smad2 Signaling Pathway in Anti-Liver Fibrosis

Download as PDF

DOI: 10.23977/medcm.2022.040710 | Downloads: 11 | Views: 486

Author(s)

Xi Yin 1, Xingwu Yang 2

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712000, China
2 Affiliated Hospital of Shaanxi University of Chinese Medicine, Hepatological Surgery, Xianyang, Shaanxi, 712000, China

Corresponding Author

Xingwu Yang

ABSTRACT

liver fibrosis is a liver disease caused by early hepatic lobule endogenetic resulting from a fibrous tissue hyperplasia and normal pathological process of protein deposition process, traditional Chinese medicine for the treatment of acute liver fibrosis with the advantages of multiple targets, multi-channel, effective control of liver fibrosis development, traditional Chinese medicine (TCM) is the current reversal fibrosis, one of the highlights in agro-scientific research in the prevention and treatment of liver diseases, this paper To summarize the research literature on the intervention of TGF-β/Smad signaling pathway by traditional Chinese medicine in anti-liver fibrosis in recent years, so as to provide ideas and references for clinical medication of anti-liver fibrosis.

KEYWORDS

Liver fibrosis, Traditional Chinese medicine, TGF-β/smad2 signaling pathway, Research progress

CITE THIS PAPER

Xi Yin, Xingwu Yang, Research Progress of Traditional Chinese Medicine Intervention on TGF-Β/Smad2 Signaling Pathway in Anti-Liver Fibrosis. MEDS Chinese Medicine (2022) Vol. 4: 64-70. DOI: http://dx.doi.org/10.23977/medcm.2022.040710.

REFERENCES

[1] MAFANDA E K. KANDHI R.BOBBALA D.et al. Essential role of suppressor of cytokine signaling 1 (SOCS1) in hepatocytes and macrophages in the regulation of liver fibrosis[J/OL]. Cytokine,no.124,pp.154501,2019.
[2] KAJI K.YOSHIJI H.IKENAKA Y.et al. Dipeptidyl peptidase-4 inhibitor attenuates hepatic fibrosis via suppression of activated hepatic stellate cell in rats[J/OL]. Journal of Gastroenterology,vol.49,no.3,pp.481-491,2014.
[3] Su Dongna. Wu Shipin. Effect of Smad7 gene plasmid transfected bone marrow mesenchymal stem cells on TGF-β1 signal transduction of hepatic stellate cells in vitro [J]. Chin J Immunology, vol.32,no.10,pp.1441-1445, 2016.
[4] XIE H.SU D.ZHANG J.et al. Raw and vinegar processed Curcuma wenyujin regulates hepatic fibrosis via bloking TGF-β/Smad signaling pathways and up-regulation of MMP-2/TIMP-1 ratio[J/OL]. Journal of Ethnopharmacology, no.246,pp.111768,2020.
[5] Yu Yang. Shi Jiayi.Huang Zhen.et al. Research progress of TGF-β/Smad signaling pathway in liver fibrosis [J]. Journal of Mudanjiang Medical College,vol.40,no.5,pp.4, 2019.
[6] Fu Lingzhu. Zheng Ting. Zhang Yongsheng. Research progress of TGF-β/Smad signal transduction pathway and liver fibrosis [J]. 2014.
[7] Han Dao-ning.SU Xiu-lan. Research progress of TGF-β/Smad signaling pathway in liver fibrosis [J]. Biomedical Translation, vol. 2,no.3,pp.8, 2021.
[8] Chen M C. Wang Z C.LV H H.et al. Research progress of traditional Chinese medicine intervention of TGF-β1/Smad signaling pathway in anti-liver fibrosis [J]. Liaoning Journal of Traditional Chinese Medicine, no.5,pp.4, 2020.
[9] MACIAS M J. MALPARTIDA P, MASSAGUe, et al. Structural determinants of Smad function in TGF-β signaling [J]. Trends in Biochemical Sciences,vol.40,no.6,pp.296-308, 2015.
[10] Wang Wei. Chen Hanhan. Wang Kai. Research progress of traditional Chinese medicine in the treatment of liver fibrosis [J/OL]. Henan Traditional Chinese Medicine, vol.41,no.1,pp.137-140, 2021.
[11] Fu Y Q. Nong X X. Su X W. et al. Research progress on the mechanism of traditional Chinese medicine anti-liver fibrosis [J/OL]. Henan Traditional Chinese Medicine,2021.
[12] Zhang Ting. Ding Yongfang. Peng Yunru. Effects of C-21 total steroid glycosides of Radix radix polygonatum on the activation of human hepatic stellate cells through TGF-β_1/Smad signaling pathway [J]. Chinese Pharmacological Bulletin, vol.37,no.9,pp.1231-1236,2021.
[13] Zhiqiang An. Qinglan Wang. Zhongping Wu. Effect of forsythoside on hepatic fibrosis in mice by regulating TGF-β1/Smad pathway [J]. Shi Zhen Guoyi Sinopang, vol.33,no.8,pp.1810-1813,2022.
[14] YUE C S. Peng A K. Ma Z J.et al. Naringenin inhibits hepatic fibrosis by regulating TGF-β1/smad pathway [J]. Chinese Pharmacological Bulletin, pp.038-002,2022.
[15] WANG Shaozhan. WANG Yuanyuan. Gu Yanqiu. et al. Quercetin plays an anti-hepatic fibrosis role by inhibiting TGF-β/TAK1/JNK and TGF-β/Smad2 signaling pathways [J]. Zhongnan Pharmaceutical Co.vol.20,no.5,pp.965-972,2022.
[16] Huang J. Zhang C. Zhan F. et al. Effect of Astragalus polysaccharide on TGF-β1/Smads signaling pathway in rats with hepatic fibrosis [J]. Chin J Traditional Chinese Medicine, vol.30,no.6,pp.3, 2015.
[17] WANG Guotai.LI Jingtao. WEI Hailiang. et al. Effects of curcumin on human hepatic stellate cell fibrosis by inhibiting TGF-β/smad2 signaling pathway [J]. Chin J Immunology, vol.36,no.4,pp.6, 2020.
[18] MU M.ZUO S. WU R M. et al. Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β /Smad signaling pathway[J/OL]. Drug Design, Development and Therapy, Vol. 12,pp.4107-4115,2018.
[19] YANG D. LI L. QIAN S. et al. Evodiamine ameliorates liver fibrosis in rats via TGF-β1/Smad signaling pathway[J/OL]. Journal of Natural Medicines, vol.72,no. 1,pp.145-154, 2018.
[20] Deng Yangyang. Ge Shanfei. Yu Yanqing. et al. Cell signal transduction pathways related to liver fibrosis and potential therapeutic strategies [J]. Journal of Clinical Hepatobiliary Diseases,vol.36,no.5,pp.1141-1145,2020.
[21] Su Yanqiu. Sun Xiaona. Sun Bin. Effects of Shipi-Ruangan pill on transaminase, transcription activator factor, transforming growth factor and platelet-derived factor in mice with hepatic fibrosis [J/OL]. Chinese Folk Medicine, vol.30,no.4,pp.84-86+105+125, 2022.
[22] Jieyang. Huang Y. Wang Zhili. et al. Effects of Shugan Jianpi Huoxue Recipe on the expression of CUG binding protein 1 and TGF-β1/Smads signaling pathway in liver tissue of mice with liver fibrosis [J/OL]. Chin J TCM,vol.63,no.13,pp.1276-1282,2022.
[23] Zhang Qiuju. WANG Kuisong. Liu Xinxin. et al. Effects of Shugan and Luoxingpi decoction on transforming growth factor-β / Drosophila maternal anti-survival factor protein signaling pathway in rats with carbon tetrachloride induced liver fibrosis [J/OL]. Chin J Clinical Pharmacology, vol.38,no.16,pp.1935-1939,2022.
[24] LI X mei. PENG J hua. SUN Z lin. et al. Chinese medicine CGA formula ameliorates DMN-induced liver fibrosis in rats via inhibiting MMP2/9, Acta Pharmacologica Sinica the relationship between TIMP1/2 and TGF-β/Smad signaling pathways[J/OL],vol.37,no.6,pp.783-793,2016.
[25] Xu L M. Interpretation of guidelines for the diagnosis and treatment of liver fibrosis with integrated traditional Chinese and Western medicine (2019 edition) [J/OL]. Shanghai Journal of Traditional Chinese Medicine, vol.54,no.3,pp.29-31+52,2020.
[26] XIA Y, YU B, MA C, et al. Yu Gan Long reduces rat liver fibrosis by blocking TGF-β1/Smad pathway and modulating the immunity[J/OL]. Biomedicine & Pharmacotherapy,vol.106,pp.1332-1338,2018.
[27] CAI F F, WU R, SONG Y N, et al. Yinchenhao Decoction enhances Liver Fibrosis by Regulating Bile Acid Metabolism and TGF-β/Smad/ERK Signalling Pathway[J/OL]. Scientific Reports, vol.8,no.1,pp.15367,2018.

Subscription
E-Mail Alert
Most popular papers
Call for Special Issue
Publication Ethics & OA Statement
Plagiarism Policy
Contact Us
Downloads: 4316
Visits: 171799

Sponsors, Associates, and Links

All published work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2016 - 2031 Clausius Scientific Press Inc. All Rights Reserved.