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  4. Vol 4, Issue 7, 2022

Probing the Mechanism of Deed of Gegenqinlian Decoction in the Care of Pediatric Rotavirus Enteritis Based on Web Pharmacology

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DOI: 10.23977/medcm.2022.040708 | Downloads: 5 | Views: 435

Author(s)

Yuqi Hao 1, Keke Wei 2, Yun Zhang 3, Qian Bian 4, Guocheng Zhang 2

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
2 Children's Hospital of the Second Affiliated Hospital of Shaanxi University of Old-Fashioned Chinese Medicine, Xianyang, Shaanxi, 712000, China
3 Jiangsu Jindike Biotechnology Co., Taizhou, Jiangsu, 225300, China
4 Ordos Hospital of Traditional Chinese Medicine, Ordos, Inner Mongolia, 017000, China

Corresponding Author

Guocheng Zhang

ABSTRACT

To probe the impression and machinery of traditional Chinese medication compound Gegen Qinlian Decoction on rotavirus enteritis in infants. Specific methods: Firstly, TCMSP database was used to search the main chemical components and functional targets of four medicinal materials, including Gegen Qinlian Decoction, and then drugs and diseases were selected The intersection of target sites was obtained and a Venn diagram was drawn. The web structure chart was constructed using the Cytoscape computer program. Eventually, R computer program was used to total analysis of the improvement of GO and KEGG pathways. Results: The 140 effective compounds, 212 targets and 33 cross genes were obtained from Gegen Qinlian decoction in treating infantile rotavirus enteritis. The 1354 consequences of biological procedure, 3 results of cell component facts and 55 outcomes of molecular function get from GO analysis. The KEGG results showed that the active ingredients in Gegen Qinlian Decoction can regulate the information channels including IL-17 protein receptor information channels, tumor necrosis factor, toll-like receptors and so on by participating in the regulation of multi-molecular receptors, so as to play a therapeutic effect on RV enteritis. Discussion consequence: The research outcomes found the mechanism of action of Gegen Qinlian Decoction on the guard against RV with multi-component, multi-target and multi-channel, and furnishing a new clinical perspective basis and new therapeutic innovation ideas for succeeding clinical investigations.

KEYWORDS

Gegenqinlian decoction, Pediatric rotavirus, Childhood viral enteritis, Network pharmacology, Information pathway, Interaction mechanism

CITE THIS PAPER

Yuqi Hao, Keke Wei, Yun Zhang, Qian Bian, Guocheng Zhang, Probing the Mechanism of Deed of Gegenqinlian Decoction in the Care of Pediatric Rotavirus Enteritis Based on Web Pharmacology. MEDS Chinese Medicine (2022) Vol. 4: 50-57. DOI: http://dx.doi.org/10.23977/medcm.2022.040708.

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