Education, Science, Technology, Innovation and Life
Open Access
Sign In
  1. Home
  2. Journals
  3. MEDS Clinical Medicine
  4. Vol 3, Issue 7, 2022

Clinical Studies on Curcumin in Improving Mitochondrial Biogenesis

Download as PDF

DOI: 10.23977/medsc.2022.030706 | Downloads: 35 | Views: 826

Author(s)

Jia Gao 1, Jie Chen 2

Affiliation(s)

1 Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi, 712046, China
2 Department of Encephalopathy, Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi'an, Shaanxi, 710003, China

Corresponding Author

Jia Gao

ABSTRACT

Curcumin is a kind of plant polyphenols extracted from the traditional Chinese medicine, turmeric. It is also the most important active ingredient of turmeric. A large body of evidence suggests that this polyphenolic compound is capable of affecting the mitochondrial structure and function, thereby improving mitochondrial biogenesis. This paper combines Chinese and foreign literature to expounds how curcumin can exert anti-inflammatory, anti-oxidation, anti-tumor, protect nervous system and cardiovascular system by improving mitochondrial biogenesis, in order to provide reference for the clinical application of curcumin.

KEYWORDS

Curcumin, Mitochondria, Mitochondrial Biogenesis

CITE THIS PAPER

Jia Gao, Jie Chen, Clinical Studies on Curcumin in Improving Mitochondrial Biogenesis. MEDS Clinical Medicine (2022) Vol. 3: 33-38. DOI: http://dx.doi.org/10.23977/medsc.2022.030706.

REFERENCES

[1] Cui Dongyue, Li Yuanyuan, Xiao Baoping, Liu Jingwen, Li Jian, Su Wenjin, Li Guiling. Preliminary mechanistic study of curcumin antioxidant effects [J]. Food Safety Guide, 2019 (20): 68-72.
[2] Raghavendhar rk, devanand ll. Curcumin:biological, pharmaceutical, nutraceutical, and analytical aspects [J/OL]. Molecules, 2019, 24(16): 2930.
[3] Trujillo J, Granados-Castro LF, Zazueta C, Andérica-Romero AC, Chirino YI, Pedraza-Chaverrí J. Mitochondria as a target in the therapeutic properties of curcumin. Arch Pharm (Weinheim). 2014; 347(12):873-84.
[4] Liao Xueyan, Wang Keshun. The protective effect of curcumin on mitochondria in cardiomyocytes under oxidative stress conditions [J]. Journal of Practical Clinical Medicine, 2019, 23 (3): 38-43.
[5] Liu Zhigang. Scientific Opinions on the Re evaluation of Food Additive Plant Carbon Melanin (E153) [J]. Chinese Journal of Food, 2012, 12 (5): 1
[6] Jaenicke L. Biochemistry. The Chemical Reactions of the Living Cell [J]. Angewandte Chemie, 1979, 91(4).
[7] Hernández-Reséndiz S, Buelna-Chontal M, Correa F, Zazueta C. Targeting mitochondria for cardiac protection. Curr Drug Targets. 2013 May 1; 14(5):586-600.
[8] Enns GM. The contribution of mitochondria to common disorders.Mol Genet Metab. 2003; 80(1-2):11-26.
[9] Ferrari CK. Functional foods, herbs and nutraceuticals: towards biochemical mechanisms of healthy aging. Biogerontology. 2004; 5(5):275-89.
[10] Kuo JJ, Chang HH, Tsai TH, Lee TY. Positive effect of curcumin on inflammation and mitochondrial dysfunction in obese mice with liver steatosis. Int J Mol Med.2012 Sep;30(3):673-9.
[11] Lu Shuyan, Yang Li, Dai Xueling, Chang Ping, Jiang Zhaofeng, Huang Hanchang. Inhibition effects of curcumin on A _ (1-42) -induced cell damage and cell apoptosis in the mitochondrial pathway [J]. The Chinese Chinese Journal of Pharmacology and Toxicology, 2017, 31 (02): 138-144.
[12] Zhang Jingfei. The protective effect of curcumin on oxidative damage in animal mitochondria and its antioxidant mechanism [D]. Nanjing Agricultural University, 2015.
[13] Q. Ma, “Role of Nrf 2 in oxidative stress and toxicity,” Annual Review of Pharmacology and Toxicology, 2013. 401–426. 
[14] M. Negrette-Guzman, W.R. Garcia-Nino, E. Tapia et al., “Curcumin attenuates gentamicin-induced kidney mito-chondrial alterations: possible role of a mitochondrial bio-genesis mechanism,” Evidence-based Complementary and Alternative Medicine. 2015, 16, 2015.
[15] Yin H, Guo Q, Li X, Tang T, Li C, Wang H, Sun Y, Feng Q, Ma C, Gao C, Yi F, Peng J. Curcumin Suppresses IL-1β Secretion and Prevents Inflammation through Inhibition of the NLRP3 Inflammasome. J Immunol. 2018; 200(8): 2835-2846.
[16] Wang Yunliang, Shi Rui, Liu Lijuan, et al. Curcumin improves insulin resistance and inflammation in nonalcoholic steatohepatitis cell model [J]. 2013.
[17] Trujillo J, Chirino YI, Molina-Jijón E, Andérica-Romero AC, Tapia E, Pedraza-Chaverrí J. Renoprotective effect of the antioxidant curcumin: Recent findings. Redox Biol. 2013 Sep 17; 1(1):448-56.
[18] Jackson JK, Higo T, Hunter WL, et al. The antioxidants curcumin and quercetin inhibit inflammatory inflammatory processes associated with arthritis [J]. Inflamm Res, 2006, 55:168-175.
[19] Esatbeyoglu T., Huebbe P., Ernst I.M., Chin D., Wagner A.E., Rimbach G.Curcumin—from molecule to biological function. Angewandte Chemie International Edition (in English) 2012; 51:5308-5332.
[20] Reddy S., Aggarwal B.B. Curcumin is a non-competitive and selective inhibitor of phosphorylase kinase.FEBS Letters. 1994; 341: 19–22.
[21] Priyanka A, Anusree SS, Nisha VM, Raghu KG. Curcumin improves hypoxia induced dysfunctions in 3T3-L1 adipocytes by protecting mitochondria and down regulating inflammation.Biofactors. 2014; 40(5):513-23.
[22] Shabaninejad Z, Pourhanifeh M H, Movahedpour A, et al. Therapeutic potentials of curcumin in the treatment of glioblstoma[J]. European Journal of Medicinal Chemistry, 2020, 188:112040.
[23] Jiang Lh, Yin Kx, Ge Mh. Research progress in curcumin’s antitumor effect and related mechanisms [J]. Jiangsu Med J (Jiangsu Pharmaceutical), 2018, 44 (7): 830-834.
[24] Yoon MJ, Kim EH, Lim JH, Kwon TK, Choi KS. Superoxide anion and proteasomal dysfunction contribute to curcumin-induced paraptosis of malignant breast cancer cells. Free Radic Biol Med. 2010; 48(5):713-26.
[25] Teresa, Valero. Mitochondrial biogenesis: pharmacological approaches. [J]. Current Pharmaceutical Design, 2014. 20(35):5507-5509.
[26] Bagheri H, Ghasemi F, Barreto GE, Rafiee R, Sathyapalan T, Sahebkar A. Effects of curcumin on mitochondria in neurodegenerative diseases. Biofactors. 2020; 46(1):5-20.
[27] Garcia-Alloza M, Borrelli LA, Rozkalne A, et al. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model [J]. J Neurochem, 2007, 102:1095-1104.
[28] Frautschy SA, Hu W, Kim P, et al. Phenolic anti-inflammatory antioxidant reversal of Abeta-induced  cognitive deficits and neuropathology[J]. Neurobiol Aging, 2001, 22:993-1005.
[29] Wu Longmei, Liu Chunyan. The protective effect of curcumin on H2O2-induced oxidative stress injury in H9C2 cardiomyocytes [J]. International Journal of Traditional Chinese Medicine, 2019 (01): 57-61.
[30] Oetikno V, Sari FR, Sukumaran V, et al. Curcumin prevents diabetic cardiomyopathy in streptozotocin-induced diabetic rats: possible involvement of PKC-MAPK signaling pathway [J]. Eur JPharm Sci, 2012, 47(3):604-614.
[31] Fan N, He Z G, Ma P P, et al. Impact of HPMC on inhibiting crystallization and improving permeability of curcumin amorphous solid dispersions [J]. Carbohyd Polym, 2018, 181:543-550.
[32] Bauer D R, Hudson B, Pecora R. Resonance enhance depolarizedrayleigh scattering from diphenylpolyenes [J]. J Chem Phys, 1975, 63: 588-591.
[33] De Oliveira MR, Jardim FR, Setzer WN, Nabavi SM, Nabavi SF. Curcumin, mitochondrial biogenesis, and mitophagy: Exploring recent data and indicating future needs.Biotechnol Adv. 2016; 34(5):813-826.

Subscription
E-Mail Alert
Most popular papers
Call for Special Issue
Publication Ethics & OA Statement
Plagiarism Policy
Contact Us
Downloads: 4423
Visits: 194537

Sponsors, Associates, and Links

All published work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2016 - 2031 Clausius Scientific Press Inc. All Rights Reserved.