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  4. Vol 4, Issue 7, 2022

Study on the Mechanism of Radix Pseudostellariae and Hedyotis Diffusa in the Treatment of Gastric Cancer Based on Network Pharmacology and Molecular Docking

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DOI: 10.23977/medcm.2022.040707 | Downloads: 7 | Views: 445

Author(s)

Xianjia Lin 1, Jian Song 1, Shuwen Shen 1

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China

Corresponding Author

Jian Song

ABSTRACT

Objective: To analyze the active ingredients and mechanism of action of the drug "Radix Pseudostellariae and Hedyotis Diffusa" in the treatment of gastric cancer using network pharmacology. Methods: The investigation was conducted by screening active chemical components and related targets of drug pairs, searching disease targets, constructing drug component-disease target network maps, mapping PPI networks between drugs and diseases, as well as GO functional enrichment analysis and KEGG pathway enrichment analysis. Results: There are 290 targets in total, and 10,411 targets for gastric cancer disease after screening, among which 183 are common targets for the treatment of gastric cancer with Radix Pseudostellariae and Hedyotis Piffusa. PPI network shows that AKT1, TP53 and IL-6 are likely to be key proteins for the treatment of gastric cancer with Radix Pseudostellariae and Hedyotis Diffusa. GO functional enrichment analysis shows that the biological process involves KEGG enrichment results involved 469 pathways, mainly including cancer pathway, Hepatitis-B pathway, PI3K-Akt signaling pathway, etc. Conclusion: The therapeutic effect of Radix Pseudostellariae and Hedyotis Diffusa  on GC through AKT1, TP53, IL-6, VEGFA, JUN and other key targets, the mechanism of action is related to cancer, Hepatitis-B, PI3K-Akt, HIF-1, TNF and other signaling pathways, involved in inflammatory response, immune regulation, vascular proliferation and other processes to play a role in the treatment of gastric cancer, for clinical application lays the theoretical foundation.

KEYWORDS

Radix Pseudostellariae, Hedyotis Diffusa, Gastric Cancer, Network Pharmacology, Molecular Docking

CITE THIS PAPER

Xianjia Lin, Jian Song, Shuwen Shen, Study on the Mechanism of Radix Pseudostellariae and Hedyotis Diffusa in the Treatment of Gastric Cancer Based on Network Pharmacology and Molecular Docking. MEDS Chinese Medicine (2022) Vol. 4: 39-49. DOI: http://dx.doi.org/10.23977/medcm.2022.040707.

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