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Research progress in the pathogenesis of breast cancer mediated by breast and intestinal flora

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DOI: 10.23977/medsc.2022.030705 | Downloads: 23 | Views: 534


Xiaoxu Zheng 1, Wenwen Dong 2, Yibo Wang 1, Renli Tian 1, Mengsheng Cui 2


1 Graduate School of Changzhi Medical College, Changzhi, Shanxi, 046000, China
2 Heping Hospital Affiliated with Changzhi Medical College, Changzhi, Shanxi, 046000, China

Corresponding Author

Mengsheng Cui


Breast cancer is the most common cancer of women and is the leading cause of death-related deaths in global female cancer. The flora is undoubtedly the second genome of the human body, playing the role of a "symbiotic creature." The breast and the intestine flora bond between cancer cells and their local environment. The flora affects breast cancer by regulating hormone metabolism, chronic inflammation, and immune system reaction. Other studies have found that diet, obesity, antibiotics, and probiotics can play an essential anti-cancer effect in breast cancer. Therefore, this article summarizes the latest research progress on the pathogenesis of breast and intestinal flora in breast cancer pathogenesis. The breast and intestinal flora are expected to become a hub for further diagnosis and treatment of breast cancer.


Breast cancer, Bacterial, Estrogen metabolism, Obesity, Diet


Xiaoxu Zheng, Wenwen Dong, Yibo Wang, Renli Tian, Mengsheng Cui, Research progress in the pathogenesis of breast cancer mediated by breast and intestinal flora. MEDS Clinical Medicine (2022) Vol. 3: 27-32. DOI:


 [1] Fernández MF, Reina-pérez I, Astorga JM, et al. Breast Cancer and Its Relationship with the Microbiota [J]. Int J Environ Res Public Health, 2018, 15(8):1747.
[2] Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries [J]. CA Cancer J Clin, 2021, 71(3):209-249. 
[3] Chadha J, Nandi D, Atri Y, et al. Significance of human microbiome in breast cancer: Tale of an invisible and an invincible [J]. Semin Cancer Biol, 2021, 70:112-127.
[4] Angelopoulou A, Field D, Ryan CA, et al.The microbiology and treatment of human mastitis [J]. Med Microbiol Immunol, 2018, 207(2):83-94.
[5] Soto-Pantoja DR, Gaber M, Arnone AA, et al. Diet Alters Entero-Mammary Signaling to Regulate the Breast Microbiome and Tumorigenesis [J]. Cancer Res, 2021, 81(14):3890-3904.
[6] Nejman D, Livyatan I, Fuks G, et al. The human tumor microbiome is composed of tumor type-specific intracellular bacteria [J]. Science, 2020, 368(6494):973-980. 
[7] Parida S, Sharma D. The power of small changes: Comprehensive analyses of microbial dysbiosis in breast cancer [J]. Biochim Biophys Acta Rev Cancer, 2019, 1871(2):392-405.
[8] Parida S, Wu SG, Siddharth S, et al. A Procarcinogenic Colon Microbe Promotes Breast Tumorigenesis and Metastatic Progression and Concomitantly Activates Notch and β-Catenin Axes [J]. Cancer Discov, 2021, 11(5):1138-1157.
[9] Plottel CS, Blaser MJ. Microbiome and malignancy [J]. Cell Host Microbe, 2011, 10(4):324-35.
[10] Vieira AT, Castelo PM, Ribeiro DA, et al. Influence of Oral and Gut Microbiota in the Health of Menopausal Women [J]. Front Microbiol, 2017, 8:1884.
[11] Alizadehmohajer N, Shojaeifar S, Nedaeinia R, et al. Association between the microbiota and women's cancers-Cause or consequences? [J]. Biomed Pharmacother, 2020, 127:110203.
[12] Ervin SM, Li H, Lim L, et al. Gut microbial β-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens [J]. The Journal of biological chemistry, 2019, 294(49):18586-18599.
[13] Bodai BI, Nakata TE. Breast Cancer: Lifestyle, the Human Gut Microbiota/Microbiome, and Survivorship [J]. Perm J, 2020, 24:19.129. 
[14] Parséus A, Sommer N, Sommer F, et al. Microbiota-induced obesity requires farnesoid X receptor [J]. Gut, 2017, 66(3):429-437.
[15] Luu TH, Michel C, Bard JM, et al. Intestinal Proportion of Blautia sp. is Associated with Clinical Stage and Histoprognostic Grade in Patients with Early-Stage Breast Cancer [J]. Nutr Cancer, 2017, 69(2):267-275. 
[16] Peters BA, Shapiro JA, Church TR, et al. A taxonomic signature of obesity in a large study of American adults [J]. Sci Rep, 2018, 8(1):9749. 
[17] Vieira-silva S, Felony G, Belda E, et al. Statin therapy is associated with lower prevalence of gut microbiota dysbiosis [J]. Nature, 2020, 581(7808):310-315.
[18] Gérard P. Gut microbiota and obesity [J]. Cell Mol Life Sci, 2016, 73(1):147-62.
[19] Shively CA, Register TC, Appt SE, et al. Consumption of Mediterranean versus Western Diet Leads to Distinct Mammary Gland Microbiome Populations [J]. Cell Rep, 2018, 25(1):47-56.e3.
[20] Mikó E, Vida A, Kovács T, et al. Lithocholic acid, a bacterial metabolite reduces breast cancer cell proliferation and aggressiveness [J]. Biochim Biophys Acta Bioenerg, 2018, 1859(9):958-974.
[21] Zengul AG, Demark-wahnefried W, Barnes S, et al. Associations between Dietary Fiber, the Fecal Microbiota and Estrogen Metabolism in Postmenopausal Women with Breast Cancer [J]. Nutr Cancer, 2021, 73(7):1108-1117.
[22] Kolátorová L, Lapčík O, Stárka L. Phytoestrogens and the intestinal microbiome [J]. Physiol Res, 2018, 67(Suppl 3):S401-S408.
[23] Tzeng A, Sangwan N, Jia M, et al. Human breast microbiome correlates with prognostic features and immunological signatures in breast cancer [J]. Genome Med, 2021, 13(1):60.
[24] Laborda-illanes A, Sanchez-alcoholado L, Dominguez-recio ME, et al. Breast and Gut Microbiota Action Mechanisms in Breast Cancer Pathogenesis and Treatment [J]. Cancers (Basel), 2020, 12(9):2465.  
[25] Wong SH, Yu J. Gut microbiota in colorectal cancer: mechanisms of action and clinical applications [J]. Nat Rev Gastroenterol Hepatol, 2019, 16(11):690-704.
[26] Nazir Y, Hussain SA, Abdul Hamid A, et al. Probiotics and Their Potential Preventive and Therapeutic Role for Cancer, High Serum Cholesterol, and Allergic and HIV Diseases [J]. Biomed Res Int, 2018, 2018:3428437.
[27] Simin J, Tamimi RM, Engstrand L, et al. Antibiotic use and the risk of breast cancer: A systematic review and dose-response meta-analysis [J]. Pharmacol Res, 2020, 160:105072.
[28] Mckee AM, Kirkup BM, Madgwick M, et al. Antibiotic-induced disturbances of the gut microbiota result in accelerated breast tumor growth [J]. iScience, 2021, 24(9):103012.
[29] Chen J, Douglass J, Prasath V, et al. The microbiome and breast cancer: a review [J]. Breast Cancer Res Treat, 2019, 178(3):493-496. 
[30] Gopalakrishnan V, Spencer CN, Nezi L, et al. Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients [J]. Science, 2018, 359(6371):97-103.
[31] Banerjee S, Wei Z, Tan F, et al. Distinct microbiological signatures associated with triple-negative breast cancer [J]. Sci Rep, 2015, 5:15162.  
[32] Frugé AD, Van der Pol W, Rogers LQ, et al. Fecal Akkermansia muciniphila Is Associated with Body Composition and Microbiota Diversity in Overweight and Obese Women with Breast Cancer Participating in a Presurgical Weight Loss Trial [J]. J Acad Nutr Diet, 2020, 120(4):650-659. 

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