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Current Status of Research on the Protective Effects of Remote Ischemic Preconditioning on the Myocardium

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DOI: 10.23977/cardvs.2022.020101 | Downloads: 20 | Views: 1176

Author(s)

Shu Song 1, Jiashuo Li 1, Yibo Wang 1, Tianxiang Chen 1, Lili Gu 1, Mengyuan Tao 1, Shuhui Sun 1, Jinkun Xi 1, Wenji Liang 1, Xiaohan Yu 1, Zhumei Sun 1

Affiliation(s)

1 School of Clinical Medicine, North China University of Science and Technology, Tangshan, Hebei, 063000, China

Corresponding Author

Zhumei Sun

ABSTRACT

After the blocked blood vessel regains blood supply, a more severe injury than the original injury will occur, called ischemia-reperfusion injury (IRI), and the current classical method to mitigate IRI is remote ischemic preconditioning (RIPC) is when severe ischemia/hypoxia occurs in essential organs of the body (heart, brain, kidneys), Intermittent blocking and re-communication of distal limbs are regulated, thereby inducing the endogenous protective mechanism in the body and exerting the ischemic protection effect of essential organs. RIPC can trigger a range of mechanisms in the body to mitigate IRI, particularly protective impacts on the heart, but the specific mechanisms are unclear. RIPC has gradually moved from basic research to clinical trials with continuous exploration. The primary purpose of this paper is to summarize the research progress of the endogenous protection mechanism of RIPC in recent years, including the study of humoral mechanism and neural mechanism; as well as to organize the clinical applications related to RIPC in recent years, suggesting the potential value of RIPC and providing ideas for future research and application of RIPC.

KEYWORDS

Remote ischemic preconditioning, Myocardial reperfusion injury, Myocardial protection mechanism, Clinical application

CITE THIS PAPER

Shu Song, Jiashuo Li, Yibo Wang, Tianxiang Chen, Lili Gu, Mengyuan Tao, Shuhui Sun, Jinkun Xi, Wenji Liang, Xiaohan Yu, Zhumei Sun, Current Status of Research on the Protective Effects of Remote Ischemic Preconditioning on the Myocardium. Cardiology and Vascular System (2022) Vol. 2: 1-10. DOI: http://dx.doi.org/10.23977/cardvs.2022.020101.

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