Education, Science, Technology, Innovation and Life
Open Access
Sign In
  1. Home
  2. Journals
  3. MEDS Clinical Medicine
  4. Vol 3, Issue 6, 2022

Clinicopathological Features of Calcitonin-Negative Thyroid Neuroendocrine Carcinoma

Download as PDF

DOI: 10.23977/medsc.2022.030613 | Downloads: 21 | Views: 489

Author(s)

Wei Zhang 1, Yongheng Wang 1, Huitong Liu 1

Affiliation(s)

1 Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, 710068, China

Corresponding Author

Huitong Liu

ABSTRACT

To clarify the clinicopathological features of calcitonin-negative thyroid neuroendocrine carcinoma. Methods The clinicopathological data of a patient with calcitonin-negative thyroid neuroendocrine carcinoma were retrospectively analyzed, and the clinical, imaging, histopathological and immunohistochemical characteristics were summarized, and the relevant literature was summarized. Results CT showed that the thyroid volume was enlarged and there were multiple low-density shadows in it. Postoperative pathological examination showed that the tumor tissue was solid nested or diffusely arranged, infiltrating the thyroid follicular space, the tumor cells were polygonal, spindle-shaped and oat-shaped, with sparse cytoplasm, easy to see apoptosis and mitotic figures, and large background Coagulative necrosis. Immunohistochemical staining showed positive expression of Syn and CD56 in tumor cells, punctate expression next to the nucleus of a few CK cells, negative expression of CEA, Tg, CgA, calcitonin and TTF-1, and Ki-67 index was about 80%. After 43 months of follow-up, the patient had multiple lung metastases. Conclusion Calcitonin-negative thyroid neuroendocrine carcinoma is rare clinically. This type of tumor is poorly differentiated, positive for immunohistochemical neuroendocrine markers and negative for calcitonin immunostaining. Fine needle aspiration is difficult to confirm the diagnosis and requires a combination of pathologic features and immunohistochemical staining for diagnosis.

KEYWORDS

Neuroendocrine carcinoma, Calcitonin-negative, Medullary carcinoma, Thyroid

CITE THIS PAPER

Wei Zhang, Yongheng Wang, Huitong Liu, Clinicopathological Features of Calcitonin-Negative Thyroid Neuroendocrine Carcinoma. MEDS Clinical Medicine (2022) Vol. 3: 75-82. DOI: http://dx.doi.org/10.23977/medsc.2022.030613.

REFERENCES

[1] Scoazec J Y, Couvelard A. Classification of pancreatic neuroendocrine tumours: Changes made in the 2017 WHO classification of tumours of endocrine organs and perspectives for the future]. Annales de pathologie, 2017, 37(6): 444-56.
[2] Eusebi V, Damiani S, Riva C, et al. Calcitonin Free Oat-Cell Carcinoma Of The Thyroid-GlanD. Virchows Archiv a-Pathological Anatomy and Histopathology, 1990, 417 (3): 267-71.
[3] Chernyavsky V S, Farghani S, Davidov T, et al. Calcitonin-negative neuroendocrine tumor of the thyroid: a distinct clinical entity. Thyroid: official journal of the American Thyroid Association, 2011, 21(2): 193-6.
[4] Mussazhanova Z, Miura S, Stanojevic B, et al. Radiation-associated small cell neuroendocrine carcinoma of the thyroid: a case report with molecular analyses. Thyroid: official journal of the American Thyroid Association, 2014, 24(3): 593-8.
[5] Nakazawa T, Cameselle-Teijeiro J, Vinagre J, et al. C-cell-derived calcitonin-free neuroendocrine carcinoma of the thyroid: the diagnostic importance of CGRP immunoreactivity. International journal of surgical pathology, 2014, 22(6): 530-5.
[6] Ismi O, Arpaci R B, Berkesoglu M, et al. Calcitonin-negative neuroendocrine tumor of thyroid gland mimicking anaplastic carcinoma: an unusual entity. Gland surgery, 2015, 4(4): 344-9.
[7] Kim G Y, Park C Y, Cho C H, et al. A Calcitonin-Negative Neuroendocrine Tumor Derived from Follicular Lesions of the Thyroid. Endocrinology and metabolism (Seoul, Korea), 2015, 30(2): 221-5.
[8] Kasajima A, Cameselle-Teijeiro J, Loidi L, et al. A Calcitonin Non-Producing Neuroendocrine Tumor of the Thyroid Gland. Endocrine pathology, 2016, 27(4): 325-31.
[9] Parmer M, Milan S, Torabi A. Calcitonin-Negative Neuroendocrine Tumor of the Thyroid: Follicular or Parafollicular Cell of Origin?. International journal of surgical pathology, 2017, 25(2): 191-4.
[10] Chorny J A, Orrego J J, CAMESELLE-TEIJEIRO J M. Primary high-grade calcitonin-negative neuroendocrine carcinoma of the thyroid: a very rare cancer. Endocrinology, diabetes & metabolism case reports, 2018, 2018.
[11] Cai H J, Wang H, Cao N, et al. Calcitonin-negative neuroendocrine tumor of the thyroid with metastasis to liver-rare presentation of an unusual tumor: A case report and review of literature. World journal of clinical cases, 2020, 8(1): 179-87.
[12] Montgomery G, Collins L, Coghlin C, et al. Calcitonin negative medullary thyroid cancer in ectopic thyroid tissue: a rare diagnosis in an unusual location. BMJ case reports, 2020, 13(8).
[13] Murphy D C, Johnson S J, Aspinall S. Calcitonin-negative medullary thyroid carcinoma: the 'triple-negative' phenotype. Annals of the Royal College of Surgeons of England, 2020, 102(3): e63-e6.
[14] Fernandez-Ferreira R, De LA Pena-Lopez I R, Zamudio-Coronado K W, et al. Calcitonin-Negative Neuroendocrine Carcinoma of the Thyroid Gland: Case Report and Literature Review. Case Reports in Oncology, 2021, 14(1): 112-22.
[15] Zheng GT, Yu GH, Chen HB, et al. A case of calcitonin-negative thyroid neuroendocrine tumor. Chinese Journal of Endocrine Surgery, 2014, (05): 438-439.
[16] Jiang H, Jiang XL, Jiang Y, et al. Clinicopathological analysis of calcitonin—negative neuroendocrine carcinoma in thyroid. Medical Journal of West China, 2018, 30(4): 498-502.
[17] Kim S J, Yun H J, Shin S J, et al. Serum Calcitonin-Negative Medullary Thyroid Carcinoma: A Case Series of 19 Patients in a Single Center. Frontiers in endocrinology, 2021, 12: 747704.
[18] Nagtegaal I D, Odze R D, Klimstra D, et al. The 2019 WHO classification of tumours of the digestive system [J]. Histopathology, 2020, 76(2): 182-8.
[19] Kabata P, Kaniuka-Jakubowska S, Kabata W, et al. Primary Ewing Sarcoma of the Thyroid-Eight Cases in a Decade: A Case Report and Literature Review. Frontiers in endocrinology, 2017, 8: 257.
[20] Zhang W, Policarpio-Nicolas M L. Aspiration cytology of primary thyroid paraganglioma. Diagnostic cytopathology, 2015, 43(10): 838-43.
[21] Zhang W, Li WS, Liu HT. Clinicopathological characteristics of diffuse large B-cell lymphoma of the thyroid in the diagnosis of fine needle aspiration biopsy. Chinese Journal of Clinical and Experimental Pathology，2022, 38(01): 103-106.
[22] Sivrikoz E, Ozbey N C, Kaya B, et al. Neuroendocrine tumors presenting with thyroid gland metastasis: a case series. Journal of medical case reports, 2012, 6: 73.
[23] Stevens T M, Richards A T, Bewtra C, et al. Tumors metastatic to thyroid neoplasms: a case report and review of the literature. Pathology research international, 2011, 2011: 238693.

Subscription
E-Mail Alert
Most popular papers
Call for Special Issue
Publication Ethics & OA Statement
Plagiarism Policy
Contact Us
Downloads: 4401
Visits: 193421

Sponsors, Associates, and Links

All published work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2016 - 2031 Clausius Scientific Press Inc. All Rights Reserved.