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  4. Vol 3, Issue 5, 2022

Research progress in the treatment of heart failure with Chinese medicine intervening mitochondrial autophagy

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DOI: 10.23977/medsc.2022.030520 | Downloads: 26 | Views: 566

Author(s)

Gendi Wang 1, Junru Zhang 2

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
2 Shaanxi Traditional Chinese Medicine Hospital, Xi'an, Shaanxi, 710003, China

Corresponding Author

Junru Zhang

ABSTRACT

Heart failure, as the final stage of the development of cardiovascular events, has a high incidence rate and a poor prognosis. How to improve its prognosis and prolong the survival of patients is the difficulty of current treatment. Mitochondrial autophagy, as a process of selective elimination of dysfunctional mitochondria, is particularly important for maintaining energy metabolism homeostasis. Many studies have shown that the occurrence and development of heart failure are closely related to the degree of mitochondrial autophagy, and appropriate mitochondrial autophagy is conducive to improving the function of myocardial cells. This article summarized the related mechanism of mitochondrial autophagy and the current research progress in the treatment of heart failure by intervention of mitochondrial autophagy with monomer or compound Chinese medicine, in order to provide more accurate and targeted guidance for the treatment of heart failure by Chinese medicine.

KEYWORDS

Heart failure, Mitochondrial autophagy, Signal path, traditional Chinese medicine

CITE THIS PAPER

Gendi Wang, Junru Zhang, Research progress in the treatment of heart failure with Chinese medicine intervening mitochondrial autophagy. MEDS Clinical Medicine (2022) Vol. 3: 110-117. DOI: http://dx.doi.org/10.23977/medsc.2022.030520.

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