A Brief Introduction to New NIT Nitroxoids
DOI: 10.23977/medsc.2022.030519 | Downloads: 6 | Views: 494
Author(s)
Liangqi Du 1, Shuonan Guo 1, Luyao Xiao 1
Affiliation(s)
1 College of Pharmacy, North China University of Science and Technology, Tangshan, 063210, China
Corresponding Author
Liangqi DuABSTRACT
Before 2021, it is estimated that there may be 9.96 million new cancer deaths and new metastasis cases per year globally. It is generally believed that chemotherapy drugs used for anticancer drugs have large toxic side effects, easy to cause tissue resistance, low selectivity, and not significant therapeutic effect. Because of the special stereoscopic structure and lipophilicity of caged compounds, some of their derivatives often have some more biological pharmacological activities, such as antiviral, enhancing cellular immunity, and anti-tumor activity. Researchers have found that a cage compound with good lipophilicity can be used as a structural unit to develop new drugs with good selectivity, high efficiency and low toxicity. NIT nitroxide radicals have excellent antitumor activity. This article reviews the design and synthesis of novel nitroxide compounds by introducing cage structure into NIT nitroxide radicals.
KEYWORDS
Cancer, Cage-like compounds, NIT free radicals, Novel nitroxide compoundsCITE THIS PAPER
Liangqi Du, Shuonan Guo, Luyao Xiao, A Brief Introduction to New NIT Nitroxoids. MEDS Clinical Medicine (2022) Vol. 3: 106-109. DOI: http://dx.doi.org/10.23977/medsc.2022.030519.
REFERENCES
[1] Yin H , Wu Y , He Y . A Brief Introduction to A New Pesticide Formulation: Emulsifiable Granual[J]. Journal of Agriculture, 2013.
[2] Liang Jing, Xiaoli Li, Xiangyang Qin, Yao, Yukun Wang. Nitrogen oxygen free radical compounds of biological activity research progress [J]. Journal of chemical reagents, and 2020 (12): 1430-1437. The DOI: 10.13822 / j.carol carroll nki HXSJ. 2020007678.
[3] Lewandowski M, Gwozdzinski K. Nitroxides as Antioxidants and Anticancer Drugs: [J]. International Journal of Molecular Sciences, 18 (11), 2490, 2017.
[4] Yokoi T, Otani T, Ishii K. In vivo fluorescence bioimaging of ascorbic acid in mice: Development of an efficient probe consisting of phthalocyanine, TEMPO, and albumin. [J]. Scientific Reports, 8(1), 1560, 2018.
[5] Findlay V.J., Townsend D.M., Saavedra J.E., Buzard G.S., Citro M.L., Keefer L.K., Ji X.H., Tew K.D. Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug. Mol. Pharmacol., 65(5), 1070-1079, 2004.
[6] Wang H.B., Gao P., Jing L.L., Qin X.Y., Sun X.L. The heart-protective mechanism of nitronyl nitroxide radicals on murine viral myocarditis induced by CVB3. Biochimie, 94(9), 1951-1959, 2012.
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