Author(s)

Jinfeng Deng ¹, Yanhong Ran ¹

Affiliation(s)

¹ Department of Bioengineering, College of Life Science, Jinan University, Guangdong, China

Corresponding Author

Yanhong Ran

ABSTRACT

The peach gum oligosaccharide (PGOP) we reported is a novel bio-degradation product of peach gum. Because of the bone structure is galactan, PGOP is expected has prebiotic and antitumor activity. This study investigates the activity of PGOP to inhibit the tumor cell proliferation and the tumor cell agglutination. The result showed that when the concentration of PGOP above 25 μg/ ml, the proliferation of Hela cell would be inhibited, and when above 50 μg/ ml, the viability of Hela cell would be inhibited either. PGOP can inhibit the cell agglutination mediated by galectin-3, and has a better inhibition than lactose. Finally, PGOP plays the role of prebiotic to promote the growth of probiotics, assists in anti-tumor.

KEYWORDS

peach gum oligosaccharide (PGOP), anti-tumor, galectin-3, probiotics

CITE THIS PAPER

Jinfeng Deng, Yanhong Ran. The Primary Antitumor Activities Study of a Novel Peach Gum Oligosaccharide. Transactions on Cancer (2020) 2: 1-6. DOI: http://dx.doi.org/10.23977/tranc.2020.020101.

REFERENCES

[1] Tang S, Wang T, Huang C, et al. Sulfated modification of arabinogalactans from larix principis-rupprechtii and their antitumor activities[J]. Carbohydr Polym, 2019, 215.
[2] b X-d D a, b Y-y F a, b Y-n L a, et al. A novel polysaccharide from castanea mollissima blume: Preparation, characteristics and antitumor activities in vitro and in vivo[J]. Carbohydr Polym, 2020.
[3] Shen W, Chen C, Guan Y, et al. A pumpkin polysaccharide induces apoptosis by inhibiting the jak2/stat3 pathway in human hepatoma hepg2 cells[J]. Int J Biol Macromol, 2017, 104: 681-686.
[4] Wasser S. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides[J]. Applied Microbiology & Biotechnology, 2002, 60(3): 258-274.
[5] Dumic J, Dabelic S, Fl?Gel M. Galectin-3: An open-ended story[J]. Biochim Biophys Acta, 2006, 1760(4): 0-635.
[6] Brandon B, Sanford G. Galectin-3 expression alters the cellular adhesion and migration response of breast cancer cells to nitric oxide[J]. Cancer Research, 2007, 67.
[7] Louis P, Scott K P, Duncan S H, et al. Understanding the effects of diet on bacterial metabolism in the large intestine[J]. Journal of Applied Microbiology, 2007, 102.
[8] Ingrid W, Gerhard R, Pool-Zobel B L. Protective role of probiotics and prebiotics in colon cancer[J]. American Journal of Clinical Nutrition, 2001, (2): 2.

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