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Research Progress on the Pharmacological Mechanism of Chuanxiong Rhizome in the Treatment of Migraine

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DOI: 10.23977/medcm.2022.040406 | Downloads: 16 | Views: 673

Author(s)

Xiaoxiao Shao 1, Hui Zhang 2, Liduo Shen 1

Affiliation(s)

1 Shaanxi University of Traditional Chinese Medicine, Xianyang, 712046, Shaanxi, China
2 Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, 712000, Shaanxi, China

Corresponding Author

Hui Zhang

ABSTRACT

Migraine is a common clinical cause of primary neurovascular headache, which is closely related to psychosocial factors and has a great impact on people's daily life. The pathogenesis of migraine is diverse, and the more mature mechanisms include vascular theory, neuronal theory, inflammatory mediator theory, neurotransmitter theory, neurotrophic factor, central sensitization and activation of the limbic system of the thalamus, and dopaminergic system-related gene theory. Chinese medicine believes that headache can occur when the evil of the six leucorrhea attacks the top of the body, stagnating the evil qi and blocking the clear yang, or when internal injuries lead to the reversal of qi, and blood, stagnation of the meridians, and loss of nourishment for the brain. Chuanxiong, as a common clinical herb, has the function of promoting blood circulation, dispelling wind, and relieving pain. Based on the pattern of medication used in the treatment of migraine during the Song, Jin, and Yuan dynasties, it was found that Chuanxiong was used very frequently in the treatment of headaches, headwinds, first wind, and migraine. In addition, modern pharmacological studies have found that the main components of Chuanxiong Ligusticum include tetramethylpyrazine (Chuanxiongzin), ferulic acid, volatile oil, ligustilide, chuanxiong lactone and alkyl phenyl peptides such as butenolide and that Chuanxiong Ligusticum has analgesic, anti-inflammatory, antioxidant, anti-tumor, anti-coagulant, anti-depressant, anti-aging, anti-atherosclerosis, cytoprotective, and cardiac function improving effects. In conclusion, Chuanxiong has great research potential in the treatment of migraine. In this paper, we mainly classify and summarize the effects of Chuanxiong in the treatment of migraine and provide a scientific basis for the application of Chuanxiong in the treatment of migraine.

KEYWORDS

Chuanxiong, migraine, chuanxiongzine, ferulic acid, ligustilide, nervous system, pharmacological mechanism

CITE THIS PAPER

Xiaoxiao Shao, Hui Zhang, Liduo Shen, Research Progress on the Pharmacological Mechanism of Chuanxiong Rhizome in the Treatment of Migraine. MEDS Chinese Medicine (2022) Vol. 4: 36-43. DOI: http://dx.doi.org/10.23977/medcm.2022.040406.

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