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  4. Vol 4, Issue 4, 2022

Discussion on the Mechanism of Wushenyin in the Treatment of Premature Ventricular Contractions of Coronary Heart Disease Based on the Network Pharmacology

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DOI: 10.23977/medcm.2022.040404 | Downloads: 10 | Views: 510

Author(s)

Mengfan Zhao 1, Borong Wang 1, Chunxian Zhao 1, Liuyi Li 1, Xiaofang Ren 2

Affiliation(s)

1 The First Clinical Medical College of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi Province, 712046, China
2 Internal Medicine-Cardiovascular Department, Xi'an Affiliated Hospital of Shaanxi University of Chinese Medicine, Xi'an, Shaanxi Province, 710021, China

Corresponding Author

Xiaofang Ren

ABSTRACT

Objective: To explore the mechanism of Wushenyin in the treatment of premature ventricular contractions (PVCs) of coronary heart disease (CHD) by TCMSP. Methods: The main chemical components of Wushen Decoction were retrieved and the target sites of the active components were predicted by using TCMSP. The targets related to PVCs of CHD were obtained from OMIM and Genecards databases, and the intersection targets were obtained by mapping the drug component targets with the disease targets using Venn diagram. String database and Cytoscape3.8.2 software were used to construct a protein interaction network for the main targets. Metascape was used to analyze the biological functions and metabolic pathways of the main targets and visualize them. Results: Finally, 140 active components of Wushenyin were obtained, corresponding to 241 targets, 2238 targets related to PVCs, and 150 targets shared by drugs and diseases. Conclusion: Through multiple targets such as STAT3, TP53 and MAPK1, the multiple components represented by quercetin in Wushenyin regulate multiple signaling pathways including PI3K-AKT, play a role in reducing inflammatory response, improving immune function, regulating cardiomyocyte metabolism and apoptosis, intervening vascular remodeling, improving myocardial blood supply and regulating bioelectrical conduction. So as to treat PVCs.

KEYWORDS

Wushen decoction, Premature ventricular beats, Coronary heart disease, Networkpharmacology, Mechanism

CITE THIS PAPER

Mengfan Zhao, Borong Wang, Chunxian Zhao, Liuyi Li, Xiaofang Ren, Discussion on the Mechanism of Wushenyin in the Treatment of Premature Ventricular Contractions of Coronary Heart Disease Based on the Network Pharmacology. MEDS Chinese Medicine (2022) Vol. 4: 22-28. DOI: http://dx.doi.org/10.23977/medcm.2022.040404.

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