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  4. Vol 3, Issue 5, 2022

To Investigate the Pathogenesis and Inflammatory Response of Premature Ventricular Contractions Based on MAPK Signaling Pathway

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DOI: 10.23977/medsc.2022.030510 | Downloads: 14 | Views: 521

Author(s)

Chunxian Zhao 1, Xiaofang Ren 2, Borui Liu 1, Liuyi Li 1, Mengfan Zhao 1, Qingchen Huang 1

Affiliation(s)

1 Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi Province, 712046, China
2 Xi'an Hospital of Traditional Chinese Medicine Affiliated to Shaanxi University of Chinese Medicine, Xi'an, Shaanxi Province, 710021, China

Corresponding Author

Xiaofang Ren

ABSTRACT

Objective: To explore the involvement of MAPK signaling pathway in the pathogenesis of premature ventricular contractions (PVCs) and the regulation of inflammatory response. Methods: A total of 40 patients with PVCs admitted to Xi'an Hospital of Traditional Chinese Medicine from June 2021 to December 2021 were randomly selected as the observation group, and 40 healthy subjects during the same period were selected as the control group. Blood samples were collected intravenously, and the levels of MAPK, IL-1β, IL-6 and TNF-αin serum of the subjects were detected by enzyma-linked immunosorbent assay (ELISA). To analyze the relationship between MAPK signaling pathway and PVC and regulation of inflammatory response. Results: Compared with the control group, the levels of serum MAPK and inflammatory factors IL-1β, IL-6 and TNF-αin observation group were significantly increased (P<0.05), and the expression of MAPK signaling pathway was highly positively correlated with the levels of inflammatory factors IL-1β, IL-6 and TNF-αin observation group. Conclusion: The pathogenesis of PVCs may be related to MAPK signaling pathway and inflammatory response. PVCs may promote the release of IL-1β, IL-6 and TNF-α by activating MAPK signaling pathway, up-regulating MAPK expression, and inducing inflammatory response.

KEYWORDS

Premature ventricular contractions (PVCs), MAPK signaling pathway, IL-1β, IL-6, TNF-α, Inflammatory reaction

CITE THIS PAPER

Chunxian Zhao, Xiaofang Ren, Borui Liu, Liuyi Li, Mengfan Zhao, Qingchen Huang, To Investigate the Pathogenesis and Inflammatory Response of Premature Ventricular Contractions Based on MAPK Signaling Pathway. MEDS Clinical Medicine (2022) Vol. 3: 57-62. DOI: http://dx.doi.org/10.23977/medsc.2022.030510.

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