Education, Science, Technology, Innovation and Life
Open Access
Sign In

A Meta-Analysis of the Prevalence of Peptic Ulcer in Chinese Adults

Download as PDF

DOI: 10.23977/phpm.2022.020401 | Downloads: 19 | Views: 444


Huan Li 1, Andong Zhao 1, Rui Xu 1, Hui Ding 2


1 Shanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi, 712046, China
2 Traditional Chinese Medicine Hospital of Shaanxi Province, Xi'an, Shaanxi, 710003, China

Corresponding Author

Hui Ding


Peptic ulcer is a common digestive system disease, with a high incidence and easy recurrence, complications, and even life-threatening, has a serious impact on the physical and mental health of patients, and the current prevalence of peptic ulcer in Chinese adults is different, has not been paid attention to by clinical doctors. Objective To systematically evaluate the prevalence of peptic ulcer in Chinese adults in order to increase clinical attention. Methods The computer searched Chinese databases (CNKI, VIP, WanFang Data, CBM) and foreign language databases (PubMed, Web of Science, EMbase, The Cochrane Library,) for cross-sectional studies of CHINESE adult PU until January 2022. The included literature was evaluated for quality and data extraction, and statistically analyzed using Stata 15.0 software. Results A total of 8 studies, including 29573 participants, were included. Meta-analysis shows that the overall prevalence of peptic ulcer in Chinese adults is 9% [95% CI (6%-11%)]. Subgroup analysis showed that the prevalence of gastric ulcers was 10.0% (95% CI (7%, 13.0%)] in men and 5% (95% CI (3%, 6%)] in women by sex; the prevalence of gastric ulcers was 8.0% (95% CI (2%, 18.0%)] in terms of location, 13% (95% CI (8%, 19%), and in terms of regional distribution, the prevalence of southern ulcers was 9.0% (95% CI (5.0%, 12.0%). , northern region prevalence 9.0% [95% CI (2.0%, 17.0%)]; In terms of age distribution, the prevalence of age ≥61 years, 51-60 years, 41-50 years, 31-40 years, and ≤30 years was 4.0% [95% CI (0%, 7.0%)], 9.0% [95% CI (0%, 19.0%)], 8.0% [95% CI (1.0%, 15.0%)] and 7.0% [95% CI (2.0%, 13.0%)] and 25.0% [95% CI (16.0%, 34.0%)] In terms of occupational types, the prevalence of soldiers, students, workers, and peasants was 1.0% [95% CI (1.0%, 2.0%)], 29.0% [95% CI (24.0%, 33.0%)], 18.0% [95% CI (7.0%, 28.0%)] and 4.0% [95% CI (1.0%, 7.0%)], respectively; in terms of survey time, the prevalence rate before 2000 was 15.0% [95% CI (4.0%, 26.0%)] , prevalence after 2000 was 5.0% [95% CI (3.0%, 7.0%)]; Conclusion The prevalence of PU in adults in China is high, and there are differences in the prevalence of different genders, occupations and regions. Although there is a gradual downward trend, it is easy to recur and has many complications, so it is still necessary to be vigilant.


Peptic ulcer, adult, Prevalence, China, Meta-analysis


Huan Li, Andong Zhao, Rui Xu, Hui Ding, A Meta-Analysis of the Prevalence of Peptic Ulcer in Chinese Adults. MEDS Public Health and Preventive Medicine (2022) Vol. 2: 1-10. DOI:


[1] Lin Guowei. Practical Internal Medicine [M] Beijing: People's Medical Publishing House, 2017: 129
[2] Wei Gyi, Liu Nannan, Wang S M, et al. Experimental research progress of anti-gastric ulcer Chinese medicine [J]. Pharmacology and Clinical practice of Traditional Chinese Medicine, 2020, 36(05): 228-232.
[3] KURATA J H, HAILE B M. Epidemiology of peptic ulcer disease [J]. Clin Gastroenterol, 1984, 13(2): 289-307.
[4] MILOSAVLJEVIC T, KOSTIĆ-MILOSAVLJEVIĆ M, JOVANOVIĆ I, et al. Complications of peptic ulcer disease [J]. Dig Dis, 2011, 29(5): 491-493.
[5] Cheng Hong, Hu Fulian, Yuan S Yuan, et al. Epidemiological analysis of peptic ulcer in Beijing area [J]. World Chinese Digestive Journal, 2007(33): 3518-3523.
[6] GUO Qingjie, CAO Zewei. Epidemiological analysis of peptic ulcer in Tianjin [J]. New Medicine, 2010, 41(02): 104-106.
[7] FENG Zhengping, LIANG Xinghua, LIU Foqiu. Gastroscopic and epidemiological analysis of 2191 patients with peptic ulcer [J]. Chongqing Medicine, 2020, 49(07): 1114-1117.
[8] ZENG B, HU Y Q, JIANG H M, et al. Investigation on pathogenesis factors of peptic ulcer in Shiyan area, Hubei Province [J]. Chinese Journal of Frontiers in Medicine (Electronic Edition), 2015, 7(05): 71-74.
[9] Bian Zhongqi, Hua Zhanlou, Zheng Dongqing. Gastroscopic analysis and epidemiological analysis of peptic ulcer [J]. Chinese Journal of Digestion, 2002(05): 53-54.
[10] YANG Jichun, YANG Zhirong, YU Shuqing, et al. Interpretation of biased risk assessment tools for interventional research in health care and quality institutions in the United States [J]. Chinese Journal of Epidemiology, 2019(01): 106-111.
[11] ZENG X, ZHANG Y, KWONG J S, et al. The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline: a systematic review [J]. J Evid Based Med, 2015, 8(1): 2-10.
[12] LI Dongli, WANG Yayu, GUO Zuiyuan, et al. Epidemiological investigation of peptic ulcer in northern soldiers [J]. advances in modern biomedicine, 2013, 13(30): 5968-5971.
[13] ZHANG M, TANG Z, ZHANG T C, et al. Investigation and analysis of the prevalence of peptic ulcer and related factors in the elderly in some parts of Beijing [J]. Chinese Journal of Epidemiology, 1998(03): 36-38.
[14] LI Xiaodan. A Preliminary Study on the Epidemiology of Peptic Ulcer Disease in Universities [J]. Chinese school doctor, 1998(03): 191-192.
[15] Cao Shiying. Epidemiological investigation of peptic ulcer [J]. Shanghai Journal of Preventive Medicine, 1994(07): 27-29.
[16] ZHANG Xudong, ZHANG Chunling, JI G F, et al. Epidemiological characteristics of peptic ulcer in the hilly area of central Sichuan——Gastroscopic analysis of 8188 cases [J]. primary health care in China, 2005(03): 90-92.
[17] ZHANG Bingyi, LI Hui. Investigation of peptic ulcer in underground workers in mines [J]. Chinese Journal of Industrial Medicine, 2008(05): 308.
[18] LIU Ronghai, LI Minsheng, LI Chenghui, et al. Epidemiological investigation of chronic gastritis and peptic ulcer in coastal residents of Sheyang County [J]. primary health care in China, 2001(04): 27-28.
[19] WANG Wen, WANG Xiaojun, WANG Rong, et al. Investigation on the incidence of peptic ulcer in a certain military and related factors [J]. PLA Medical Journal, 2006(09): 869-872.
[20] ZHANG Wei, GE Zhizheng, LU Hong. Characteristics of positive peptic ulcer in Helicobacter pylori from 2013 to 2019 [J]. Gastroenterology, 2020, 25(11): 670-672. 
[21] XIE X, REN K, ZHOU Z, et al. The global, regional and national burden of peptic ulcer disease from 1990 to 2019:  a population-based study [J]. BMC Gastroenterol, 2022, 22(1): 58.
[22] KHUROO M S, MAHAJAN R, ZARGAR S A, et al. Prevalence of peptic ulcer in India: an endoscopic and epidemiological study in urban Kashmir [J]. Gut, 1989, 30(7): 930-934.
[23] SOBIERAJ D M, COLEMAN S M, COLEMAN C I. US prevalence of upper gastrointestinal symptoms: a systematic literature review [J]. Am J Manag Care, 2011, 17(11): e449-e458.
[24] REPLOGLE M L, GLASER S L, HIATT R A, et al. Biologic sex as a risk factor for Helicobacter pylori infection in healthy young adults [J]. Am J Epidemiol, 1995, 142(8): 856-863.
[25] BÖHMER C J, KLINKENBERG-KNOL E C, KUIPERS E J, et al. The prevalence of Helicobacter pylori infection among inhabitants and healthy employees of institutes for the intellectually disabled [J]. Am J Gastroenterol, 1997, 92(6): 1000-1004.
[26] HOLSTEGE A. [Effects of nicotine, alcohol and caffeine on the incidence, healing and recurrence rate of peptic ulcer] [J]. Z Gastroenterol, 1987, 25 Suppl 3: 33-40.
[27] ZHANG Xinhong. Comparison of gastroscopic incidence of gastric and duodenal ulcer [J]. Frontiers of Chinese Medical Care, 2012, 7(12): 36-65.
[28] LU Shengju, JIN Tianshu. Clinical features and influencing factors of peptic ulcer associated with elderly NSAIDs [J]. Chinese Journal of Gerontology, 2020, 40(03): 539-542.
[29] CHING C K, LAM S K. Helicobacter pylori epidemiology in relation to peptic ulcer and gastric cancer in south and north China [J]. J Gastroenterol Hepatol, 1994,9 Suppl 1: S4-S7.
[30] BAI Wenyuan, ZHOU Chao, GUO Dongmei. Clinical epidemiology of peptic ulcer [J]. Medicine and Philosophy (Clinical Decision Forum), 2010, 31(05): 11-12.
[31] CHEN Haozhu. Practical Internal Medicine [M]. 12th edition. Beijing: People's Medical Publishing House, 2005: 1866-1877.
[32] NI Qun, LIU You-kang, DU You-sheng, et al. Analysis of the incidence of peptic ulcer in college students from 1994 to 2005 [J]. Zhejiang Preventive Medicine, 2006(11): 78-82.
[33] SHI Xiaolin. Clinical analysis of 48 cases of peptic ulcer in high school students [J]. Chinese School Health, 2005(02): 146.
[34] ZHANG X J, MA Li Z, LI Z T, et al. Influencing Factors of Functional Dyspepsia of Coal Miners [J]. Journal of North China University of Science and Technology (Medical Edition), 2018, 20(02): 145-147.
[35] YANG Zhizhong. Discussion on the correlation between peptic ulcer and occupational tension in coal mine underground workers [J]. Public Health Management in China, 2019, 35(06): 782-785.
[36] LI Yangfan, LIU Weihua, ZHI Yongfen, et al. Occupational tension and influencing factors of coke oven workers in a coking plant [J]. Environmental and Occupational Medicine, 2016, 33(06): 547-552.
[37] YU Xuchao. Observation of clinical efficacy of liver and spleen thinning method in the treatment of peptic ulcer with anxiety and depression [D]. Chengdu University of Traditional Chinese Medicine, 2017. 
[38] HUANG Gen. Clinical characteristics and trend of peptic ulcer[D]. Nanchang University, 2021. 
[39] XIA H H, PHUNG N, ALTIPARMAK E, et al. Reduction of peptic ulcer disease and Helicobacter pylori infection but increase of reflux esophagitis in Western Sydney between 1990 and 1998 [J]. Dig Dis Sci, 2001, 46(12): 2716-2723.
[40] JYOTHEESWARAN S, SHAH A N, JIN H O, et al. Prevalence of Helicobacter pylori in peptic ulcer patients in greater Rochester, NY: is empirical triple therapy justified? [J]. Am J Gastroenterol, 1998, 93(4): 574-578.

Downloads: 1139
Visits: 50285

Sponsors, Associates, and Links

All published work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2016 - 2031 Clausius Scientific Press Inc. All Rights Reserved.