Research Progress of Central Insulin Resistance and Cognitive Impairment
DOI: 10.23977/medsc.2022.030414 | Downloads: 11 | Views: 125
Tong Yu 1, Hai Lin 2, Yunyun Li 1
1 Shaanxi University of Chinese Medicine, Shaanxi, 712046, China
2 Xi'an Traditional Chinese Medicine Hospital, Shaanxi, 710021, China
Corresponding AuthorHai Lin
With the acceleration of the aging of the world's population, the number of patients with cognitive dysfunction has increased significantly, resulting in more and more serious social problems, economic problems, family problems and public health problems, how to better prevention and treatment of cognitive dysfunction is also a hot spot of clinical research. Studies have shown that insulin resistance and compensatory hyperinsulinemia (HI) exist in many patients with cognitive dysfunction, which also provides new ideas for the prevention and treatment of dysfunction. At present, more attention has been paid to peripheral insulin resistance, but there is little discussion on cognitive dysfunction caused by central insulin resistance. Insulin receptors (InsRs) are widely distributed in the brain region, especially in the hippocampus. Insulin can be through the blood - brain barrier to enter the central nervous system, adjust the structure of cerebral glucose metabolism and brain plasticity, protect nerve cells, improve memory, in order to protect the nervous system and cognitive function, while type 2 diabetes mellitus (T2DM) patients with insulin resistance, in turn, cause central insulin resistance can cause cognitive dysfunction . Therefore, the effects of central insulin resistance on cognitive function and related mechanisms have gradually become a research hotspot. This paper summarizes the current research situation.
KEYWORDSCentral insulin resistance, Cognitive dysfunction, The hippocampus, Insulin resistance
CITE THIS PAPER
Tong Yu, Hai Lin, Yunyun Li, Research Progress of Central Insulin Resistance and Cognitive Impairment. MEDS Clinical Medicine (2022) Vol. 3: 90-94. DOI: http://dx.doi.org/10.23977/medsc.2022.030414.
 Wang Meng, Ji Wenjun, Chen Lina. Research progress of diabetic cognitive dysfunction [J]. Basic Medicine & Clinic, 2015(02): 240-243. (In Chinese)
 Gao Li, Zhang Yingdong. Research progress on the role of insulin in the pathogenesis of Alzheimer's disease [J]. Chin J Clinical Neuroscience, 2010(03): 318-321+332.
 Grasso G, Mielczarek P, Niedziolka M, Silberring J. Metabolism of cryptic peptides derived from neuropeptide FF precursors: the involvement of insulin-degrading enzyme. Int J Mol Sci 2014; 15(9): 16787–99.
 ZHAO X. Effects of central insulin resistance on neuron-astrocyte intermetabolic coupling and neuronal function [D]. Jilin University, 2018.
 Jiang Rongrong, Tang Ni, Wang Xiaobin. Insulin resistance and cognitive dysfunction in elderly patients. [J]. Southwest Military Med. 2015(01): 41-43.
 Li Y. The relationship between central insulin resistance and Alzheimer's disease [J]. Diagnostics Theory and Practice. 2009(03): 248-251.
 Gu Ping, Wang Jian. Research progress of insulin metabolism/signal transduction in central nervous system and Alzheimer's disease [J]. Chinese Journal of Gerontology. 2010(07): 1006-1009.
 Diwu yongchang, Shi Jing. The relationship between insulin resistance and cognitive impairment [J]. Chin J Gerontology, 2009(16): 2121-2124. (In Chinese)
 CAO Y. The mechanism of hypoglycemic drugs regulating brain metabolism and improving spatial memory impairment in central insulin resistance mice [D]. Jilin University, 2018.
 Zhao X, Cao Y, Lv Y, et al. Effects of Central Insulin Resistance on Neuronal Functions and Metabolic Coupling between Neurons and Astrocytes[J]. Available at SSRN 3234807, 2018.
 Liu Y, Kang J. Effect of Buyang Huanwu decoction on central insulin resistance in rats with metabolic syndrome [J]. Hubei Journal of Traditional Chinese Medicine. 2015 (09): 9-11.
 Sunmin Park, Suna Kang, Da Sol Kim & Bo Rerum Moon. Agrimonia pilosa Ledeb, Cinnamomum cassia Blume, and Lonicera japonica Thunb. protect against cognitive dysfunction and energy and glucose dysregulation by reducing neuroinflammation and hippocampal insulin resistance in β-amyloid-infused rats. Nutritional Neuroscience. 2016. 1476-8305.
 Cai Jizhang. Effect of berberine on cognitive function in AD rats and its mechanism [D]. Changsha: Central South University, 2013.
 Liu Qiongzhen, Lv Wenting, Cai Minxuan, et al. Effects of metabolic diseases on mood and cognitive function and its possible mechanism. [J]. Chinese Journal of Pharmacology and Toxicology, 2015(05): 847-858.
 Zhao Xiaohong, Tan Yue, Bao Juan, Li Jinghui. The relationship between insulin resistance and mild cognitive impairment. [J]. Stroke and Neuropathy, 2009(03). 155-158.
 Tucsek Z, Toth P, Sosnowska D, et al. Obesity in aging exacerbates blood-brain barrier disruption, neuroinflflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease. J Gerontol A Biol Sci Med Sci 2014; 69(10): 1212-26.
 Biessels GJ, Reagan LP. Hippocampal insulin resistance and cognitive dysfunction. Nat Rev Neurosci. 2015: (16) 660-671.