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Research Progress of Central Insulin Resistance and Cognitive Impairment

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DOI: 10.23977/medsc.2022.030414 | Downloads: 11 | Views: 125


Tong Yu 1, Hai Lin 2, Yunyun Li 1


1 Shaanxi University of Chinese Medicine, Shaanxi, 712046, China
2 Xi'an Traditional Chinese Medicine Hospital, Shaanxi, 710021, China

Corresponding Author

Hai Lin


With the acceleration of the aging of the world's population, the number of patients with cognitive dysfunction has increased significantly, resulting in more and more serious social problems, economic problems, family problems and public health problems, how to better prevention and treatment of cognitive dysfunction is also a hot spot of clinical research. Studies have shown that insulin resistance and compensatory hyperinsulinemia (HI) exist in many patients with cognitive dysfunction, which also provides new ideas for the prevention and treatment of dysfunction. At present, more attention has been paid to peripheral insulin resistance, but there is little discussion on cognitive dysfunction caused by central insulin resistance. Insulin receptors (InsRs) are widely distributed in the brain region, especially in the hippocampus. Insulin can be through the blood - brain barrier to enter the central nervous system, adjust the structure of cerebral glucose metabolism and brain plasticity, protect nerve cells, improve memory, in order to protect the nervous system and cognitive function, while type 2 diabetes mellitus (T2DM) patients with insulin resistance, in turn, cause central insulin resistance can cause cognitive dysfunction [1]. Therefore, the effects of central insulin resistance on cognitive function and related mechanisms have gradually become a research hotspot. This paper summarizes the current research situation.


Central insulin resistance, Cognitive dysfunction, The hippocampus, Insulin resistance


Tong Yu, Hai Lin, Yunyun Li, Research Progress of Central Insulin Resistance and Cognitive Impairment. MEDS Clinical Medicine (2022) Vol. 3: 90-94. DOI:


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