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  4. Vol 3, Issue 3, 2022

Analysis of high-risk HPV infection and cervical HPV in 10670 women

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DOI: 10.23977/medsc.2022.030314 | Downloads: 5 | Views: 540

Author(s)

Tao Bai 1, Ynchun Qian 1, Yao Yuan 1, Jing Cai 2

Affiliation(s)

1 Shaanxi University of Traditional Chinese Medicine, Xianyang, 71200, Shaanxi, China
2 Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang, 71200, Shaanxi, China

Corresponding Author

Jing Cai

ABSTRACT

Objective To analyze the infection of cervical high-risk HPV (HR-HPV), study the correlation of cervical HR-HPV infection and help the clinical cervical cancer screening. Methods Statistics from January 2019 to December 2020 in the gynecological outpatient department of 10670 women of cervical HPV infection, among which 731 patients with cervical HR-HPV infection underwent colposcopy + cervical biopsy, analyzed the relationship between cervical HR-HPV infection and cervical pathology results, clear the association between cervical HR-HPV infection and cervical lesions. Results 10670 female HR-HPV patients, with the highest number of 20.00% (347/1738), and the top 5 single infections were 16,52,58,53 and 51.HR-HPV infected patients were divided into four categories according to type 16,18, other 13 and multiple infections, and the other 13 types accounted for the most proportion, with 59.09% (1027/1738).The 347 patients with multiple infection had the highest rate of other type 13 coinfection, accounting for 60.23% (209/347).A total of 1738 patients with HR-HPV infection were divided into five groups according to their age, and the number of women aged 41 to 50 was the largest (29.34%), second by> 50 years (28.48%), with HPV16 and 18 infections mainly from 41 to 50 and> 50 years, as were other 13 high-risk HPV infections.HR-HPV infection at different ages was statistically significant (c2=61.419, P=0.000<0.05).In 731 patients with HR-HPV infection undergoing cervical biopsy in our hospital, pathological cervical low-grade intraepithelial lesions were mainly other type 13 infections, accounting for 58.17% (356/612); cervical high-grade intraepithelial lesions were mainly type 16 infections (including single type 16,16 and other type 13 infections), accounting for 67.23% (80/119).The distribution of HR-HPV type in the pathological diagnosis of cervical biopsy was statistically significant (c2=126.830, P=0.000<0.05).Conclusion HR-HPV infection can increase the incidence of cervical precancerous lesions and cervical cancer is mainly type HPV16.

KEYWORDS

High-risk HPV (HR-HPV), cervical lesions

CITE THIS PAPER

Tao Bai, Ynchun Qian, Yao Yuan, Jing Cai, Analysis of high-risk HPV infection and cervical HPV in 10670 women. MEDS Clinical Medicine (2022) Vol. 3: 81-89. DOI: http://dx.doi.org/10.23977/medsc.2022.030314.

REFERENCES

[1] Zhou Hui, Wang Dongyan, Luo Ming, Lin Zhongqiu.FIGO 2018 Women Cancer Report —— Cervical Cancer Guide Interpretation [J]. Chinese Journal of Practical Gynecology and Obstetrics, 2019,35 (01): 95-103.
[2] Kuehn Bridget M. WHO Launches Global Push to Eliminate Cervical Cancer [J]. JAMA, 2021, 325(3): 213-213.
[3] Shan Wei, Zhang Tao, Zhang Tiejun, Zhao Genming.Epidemiological status of female human papillomavirus (HPV) infection in China [J]. Chinese Journal of Disease Control, 2017, 21 (01): 89-93.
[4] Janice Beard, Stone Antoinette. Interpretation of the 4th edition of the WHO histological Classification of female reproductive organ tumors [J]. International Journal of Obstetrics and Gynecology, 2014, 41 (06): 697-704.
[5] Xie Shanyan, Ren Peng. Analysis of the trend of cervical cancer and corresponding strategies [J]. Journal of Traditional Chinese Medicine Management, 2018,26 (05): 10-12.
[6] Hu Jing, Luna. Analysis of the distribution relationship between cervical lesions and cervical HPV subtypes in 620 women in Huangshi City [J]. New Clinical New Medicine in China, 2018,11 (04): 372-375.
[7] Liao Hongli, Lin Peng, Ye Qiong.Correlation analysis of high-risk HPV infection and the extent of cervical intraepithelial neoplasia-like lesions in women [J]. China Maternal and Child Health Research, 2020,31 (09): 1268-1272.
[8] Li Huaping, Li Peiqun, Huang Luyi, Sun Liping, Ren He,Li Ping. Prevalence characteristics of cervical human papillomavirus (HPV) infection in the Zhoupu District, Shanghai City, China. [J]. Virology journal, 2020, 17(1).
[9] Liu Zongchao, Li Zhexuan, Zhang Yang, Zhou Tong, Zhang Jingying, You Weicheng, Pan Kaifeng, Li Wenqing.2020 Global Cancer Statistics Report Interpretation [J]. Electronic Journal of Comprehensive Treatment of Oncology, 2021,7 (02): 1-14.
[10] Zhang Guohua, Wang Yirong, Wang Xiuyun.Professor Wang Xiuyun has gained experience in the treatment of persistent HPV infection [J]. Journal of Liaoning University of Traditional Chinese Medicine, 2021,23 (06): 16-19.
[11] Chen Yi, Wu Dan, Li Zhennan, Zhang Zhengrong, Xu Ying, Meng Yu, Lin Jing.Clinicopathological analysis of 770 patients with high-risk HPV persistent infection [J]. Prevention and Control of Chronic Diseases in China, 2018,26 (07): 529-532.
[12] Liu Xiaohua, Long Honghui, Chen Yuning, Jin Pu, Ding Xianping.Correlation analysis of high-risk HPV infection and cervical lesions [J]. Chinese Journal of Eugenand Genetics, 2020,28 (08): 1008-1009 + 1028.
[13] Wang Shanyun, Zeng Jianfeng. Clinical value of Cobas4800 high-risk HPV classification in cervical cancer screening in Zhongshan city [J]. Medical Theory and Practice, 2020, 33 (13): 2196-2198.
[14] Shanyun Wang, Xijun He, Fansu Meng, Qianyi Pan, Lin Zhang, Jianfeng Zeng, Paola Di Carlo. Application of the Cobas 4800 System for the Detection of High-Risk Human Papillomavirus in 5650 Asymptomatic Women [J]. BioMed Research International,2020,2020.
[15] Wang Yuanyuan, Peng Yanyan, Liu Chunpeng, Liao Lihua, Zheng Jie, Wang Shaohong, Gong Guoliang.Distribution and significance of high-risk HPV multiple infection in cervical squamous cell lesions [J]. Journal of Clinical and Pathology, 2019,39 (12): 2692-2696.
[16] Mariel A. Oyervides-Muñoz, Antonio A. Pérez-Maya, Celia N. Sánchez-Domínguez, Anais Berlanga-Garza, Mauro Antonio-Macedo, Lezmes D. Valdéz-Chapa, Ricardo M. Cerda-Flores, Victor Trevino, Hugo A. Barrera-Saldaña, María L.Garza-Rodríguez. Multiple HPV Infections and Viral Load Association in Persistent Cervical Lesions in Mexican Women[J].Viruses,2020,12(4).
[17] Jin Xiuping, Ling Weijiang, Yu Yueping, Liu Xiaoxiang, Sun Aihua.Investigation on high-risk HPV infection and subtype distribution among gynecological women in Shaoxing area [J]. Chinese General Practice, 2015,13 (01): 66-68+ 71.
[18] Shao Minfang. Relationship between multiple HPV infection and cervical lesions [D]. Soochow University, 2016.
[19] Zhou Qin, Qian Wenyan, Zhu Yan, Jiang Wenbo, Gu Xuefang, Wu Sufang. Analysis of cervical HR-HPV infection in 1,081 patients [J]. Modern oncology medicine, 2018, 26 (06): 917-919.
[20] Zhang Yiping, Liang Baoxia, Xue Yufeng, Elegant Lu. The relationship between the infection status of the human papillomavirus subtype and the cervical lesions [J].Ningxia Medical Journal, 2016,38 (10): 905-908.
[21] Yu Chunli. Correlation of high-risk HPV infection and cervical cancer [J]. Journal of Practical Gynecological Endocrinology (electronic edition), 2017,4 (21): 101 + 103.
[22] Wang Shuai Shuai. Characteristics of cervical lesions and HPV infection in Qinghai region from 2013-2017 [D]. Qinghai University, 2018.
[23] Guo Yu, Lin Lihong, Gao Yanrong. Correlation study of high-risk HPV infection and cervical cancer and precancerous lesions [J]. Chinese Journal of Cancer Prevention and Treatment, 2018, 25 (03): 156-158.
[24] Zhang Wenhua, Guan Dongdong. Application of high-risk HPV testing in cervical cancer screening in rural women [J]. China Health Standard Management, 2018,9 (17): 75-78.
[25] Yao Xueqin, Ye Shimin, He Shuyu, Liu Bin, Wu Youfeng. Pathological outcome analysis of different TCT outcomes in women with high-risk HPV infection in Bijie, Guizhou Province [J]. Guizhou Medicine, 2019,43 (08): 1333-1335.
[26] Zhu Yue, Jiang Nan, Xu Yaru. Correlation of high-risk HPV infection and cervical cancer [J]. Contemporary medicine theory cluster, 2019,17 (15): 93-94.
[27] Li Xingchan, He Yating, Zhao Yu. Analysis of the relationship between high-risk HPV infection and cervical cancer [J].Chinese Medical Sciences, 2020, 10 (16): 71-73.
[28] He Mei. Application value of HPV subtyping test in the screening of cervical cancer and precancerous lesions [J]. Shenzhen Journal of Integrated Traditional Chinese and Western Medicine, 2020,30 (03): 79-80.
[29] L.YU, X.MA, Y.HUA, X.YU, N.YAN AND Z.LI*.The Relationship between Human Papillomavirus Infection and Cervical Precancerous Lesions [J]. Indian Journal of Pharmaceutical sciences,2020,82(2020: Drug Development and Human Health in China (Special Issue)).
[30] Duan L F, Du H, Xiao A M, Wang C, Huang X, Zhao M F, Men H J, Wu R F.[Relationship between cervical lesions and the type-specific viral load of high risk HPV reflected by the Ct value of Cobas 4800 HPV system].[J].Zhonghua fu chan ke za zhi, 2019, 54(7).
[31] Bian Yihua, Sun Lihua. Retrospective analysis of cervical status in 570 women with positive high-risk HPV-DNA test [J]. Maternal and Child Health Care in China, 2014,29 (01): 53-55.
[32] He Xin, Tao Huicheng, Liu Chen, Wang Shuzhen, Wang Yue, Diao Xiaoli, Qu Jiuxin. Epidemiological characteristics of HR-HPV infection and its relationship with cervical precancerous lesions [J].Journal of Capital Medical University, 2015,36 (02): 219-225.
[33] Li Chunhong, Hu Zhi. Significance of high-risk HPV typing test for screening of cervical cancer and precancerous lesions [J]. Maternal and Child Health Care in China, 2016,31 (09): 1827-1829.
[34] Yang Xiaofei, Xie Ningna, Song Shufang. Study on cervical HPV infection and association with cervical lesions in patients attending gynecological outpatient clinics in Central Inner Mongolia [J]. Progress in modern Obstetrics and Gynecology, 2018,27 (06): 446-451.
[35] Zhang Qing, Lv Yafang, Sun Weijing. Clinical study on the effect of high-risk HPV typing test on the screening of cervical cancer and precancerous lesions [J]. Grassroots Medicine Forum, 2019,23 (04): 452-454.
[36] Fang Li, Han Yu, Xu Yuan, Chen Ying, Zheng Yang. Correlation of high-risk HPV infection and cervical cancer [J]. Chinese Experimental Diagnostics, 2019, 23 (04): 602-605.
[37] Liu Jing, Deng Chaohong, Bud Mara. Distribution of high-risk HPV subtypes and correlation with cervical lesions in women in Korla City [J]. Chinese Clinical Journal of Obstetrics and Gynecology, 2020,21 (05): 502-503.
[38] Jiang Yingying, Xu Wei, Tao Junzhen. Analysis of the high-risk HPV infection status and its correlation with cervical lesions [J]. China Maternal and Child Health Research, 2020,31 (05): 671-675.
[39] Zhiling Wang, Ting Liu, Yunjian Wang, Ying Gu, Hui Wang, Jingkang Liu, Baoxia Cui, Xingsheng Yang. Risk of cervical lesions in high-risk HPV positive women with normal cytology: a retrospective single-center study in China [J]. Infectious Agents and Cancer, 2020, 15(9295).
[40] Xu Huihui, Zhu Haiyan, Zhang Tongtong, Shang Xianwen, Yu Jiasheng, Yan Weihua. Risk study of high-risk HPV infection in the progression of cervical lesions [J]. Chinese Journal of Experimental and Clinical Virology, 2017,31 (04): 302-306.
[41] Zhang Yi, Wang Jianjun. Correlation between different high-risk types of HPV infection and cervical cancer and cervical high-grade lesions [J]. Journal of Tongji University (Medical edition), 2018,39 (03): 59-63.
[42] Zhou Qin, Qian Wenyan, Zhu Yan, Jiang Wenbo, Gu Xuefang, Wu Sufang. Analysis of cervical HR-HPV infection in 1,081 patients [J]. Modern oncology medicine, 2018, 26 (06): 917-919.
[43] Sontakke Bharat R, Ambulkar Prafulla S, Talhar Shweta, Shivkumar Poonam Varma, Bharambe M S, Pal Asoke. Molecular Genetic Study to Detect Prevalence of High-risk Human Papilloma Virus Strains (type 16 and 18) in Cervical Lesions and Asymptomatic Healthy Subjects of Rural Central India. [J]. Journal of cytology, 2019, 36(1).
[44] Zhou Juan. Analysis of HPV infection in Wenshan Prefecture, Yunnan Province [D]. Youjiang Medical College for Nationalities, 2020.
[45] Wang Zhiling, Gu Ying, Wang Hui, Chen Junyu, Zheng Yawen, Cui Baoxia, Yang Xingsheng. Distribution of cervical lesions in high-risk HPV (hr-HPV) positive women with ASC-US: a retrospective single-center study in China. [J]. Virology journal, 2020, 17(1).
[46] Ozturk Emine, Ince Onur, Karaca İbrahim, Demirayak Gokhan, Comba Cihan, Alay Ismail, Erdogan Volkan Sakir, Yıldırım Karaca Suna,Ozdemir Isa Aykut.The impact of concurrent HPV infections on the presentation of high grade cervical intraepithelial lesions.[J]. Ginekologia polska, 2020,91(6).
[47] Chen Caixia. Correlation and clinical significance analysis of human papillomavirus gene subtype and cervical lesions [J]. Medical Theory and Practice, 2021,34 (01): 130-132.
[48] Hua Xianli, Li Jinghe. Analysis of HPV subtypes of multiple human papillomavirus infection and its significance in cervical lesions [J]. Shenzhen Journal of Integrated Traditional Chinese and Western Medicine, 2021,31 (11): 43-45.
[49] Wang Li, He Yu, Xu Chi. Value of HPV subtyping testing in the diagnosis of cervical lesions [J]. Maternal and Child Health Care in China, 2021,36 (06): 1232-1234.
[50] Fan Qiong, Huang Ting, Sun Xiao, Wang YiWei, Wang Jing, Liu Yao, Ni Ting, Gu ShengLan, Li YuHong, Wang YuDong. HPV‐16/18 E6‐induced APOBEC3B expression associates with proliferation of cervical cancer cells and hypomethylation of Cyclin D1 [J]. Molecular Carcinogenesis, 2021, 60(5).
[51] da Costa Ana Rita Fernandes Miranda, Sousa Cláudia, Isidoro Erica, Silva Regina, Mourato Cristiana. High-risk HPV genotypes and cervical lesions association in postmenopausal women [J]. European Journal of Public Health, 2021, 31(Supplement2).
[52] Zhong Wei Jing, Liang Hao He. Analysis of HPV typing test combined with cervical TCT and cervical biopsy results in Zhaoqing women [J].Chinese Medical Engineering, 2020,28 (03): 91-93.
[53] Dube Mandishora Racheal S, Rounge Trine B, Fitzpatrick Megan, Christiansen Irene Kraus, Ambur Ole Herman, Lagström Sonja, StrayPedersen Babill,Tommasino Massimo, Palefsky Joel, Chirenje Zvavahera M. Self-collected and clinician-collected anal swabs show modest agreement for HPV genotyping. [J]. PloS one, 2021, 16(4).
[54] Yuill Susan, Egger Sam, Smith Megan, Velentzis Louiza, Wrede C David, Bateson Deborah, Canfell Karen. Has Human Papillomavirus (HPV) Vaccination Prevented Adverse Pregnancy Outcomes? Population-Level Analysis After 8 Years of a National HPV Vaccination Program in Australia. [J]. The Journal of infectious diseases,2020, 222(3).
[55] Ding Zhanping, Tong Re-o.Investigation and analysis of HPV infection among women of childbearing age in Shijiazhuang [J]. Maternal and Child Health Care in China, 2019,34 (16): 3777-3780.

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