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  4. Vol 3, Issue 3, 2022

Study on the mechanism of shejianlian compound regulating the transformation of viral hepatitis, inflammation and cancer based on PI3K Akt / WT1

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DOI: 10.23977/medsc.2022.030308 | Downloads: 9 | Views: 965

Author(s)

Zhuoran Ji 1, Man Wang 2, Mingxia Hao 2, Xiaoni Kou 2

Affiliation(s)

1 Shaanxi University of traditional Chinese medicine, Shaanxi Xianyang 712000, China
2 Affiliated Hospital of Shaanxi University of traditional Chinese Medicine, Shaanxi Xianyang 712000, China

Corresponding Author

Xiaoni Kou

ABSTRACT

Chronic hepatitis B is a systemic infectious disease caused by hepatitis B virus infection. Hepatitis B patients with hepatitis B in the world develop to cirrhosis or even liver cancer. In the process of inflammatory transformation, liver fibrosis is reversible, but the time of reversal is too slow. At present, there is no approved drug for the treatment of liver fibrosis, so the advantage of Chinese medicine in the prevention of liver fibrosis is particularly prominent. 20%-30% Shejianlian compound is composed of Hedyotis diffusa, Shijianchuan and Scutellaria barbata. Based on PI3K Akt / WT1, it can effectively prevent the transformation of viral hepatitis to liver cirrhosis and liver cancer. This paper discusses the mechanism of shejianlian compound regulating inflammatory and cancer transformation through PI3K Akt / WT1.

KEYWORDS

Shejianlian compound, Hepatitis, liver cancer, Inflammatory transformation, mechanism

CITE THIS PAPER

Zhuoran Ji, Man Wang, Mingxia Hao, Xiaoni Kou, Study on the mechanism of shejianlian compound regulating the transformation of viral hepatitis, inflammation and cancer based on PI3K Akt / WT1. MEDS Clinical Medicine (2022) Vol. 3: 43-48. DOI: http://dx.doi.org/10.23977/medsc.2022.030308.

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