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Effects of Elastin Peptide on Antioxidative Defence of Photoaging Mice

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DOI: 10.23977/phpm.2022.020209 | Downloads: 2 | Views: 113


Zheng Yan 1, Haiyan Wang 2, Aiqing Liu 2, Hailong Yu 1, Bin Jiang 1, Zhimin Xu 2, Zhiguo Li 2


1 Collage of Bioengineering, Beijing Polytechnic, Beijing 100176, China
2 Beijing Semnl Biotechnology Co., Ltd., Beijing 100062, China

Corresponding Author

Zheng Yan


Ultraviolet (UV) radiation in sunlight is the main exogenous factor underlying the aging of skin. The objective of the present study was to create a hairless mouse model of photoaging via the application of UVA+UVB irradiation for 14 weeks. To study the protective effects of the oral administration of elastin peptide, the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT), and malondialdehyde (MDA) level in the serum of irradiated mice were measured. Pretreatment with different doses of elastin peptide before UV irradiation could effectively promote the SOD, GSH-Px and CAT activities in serum of mice and reduce the expression MDA level. In conclusion, elastin peptide can effectively repairing cells by removing superoxide free radicals from UV damage. This study proved the possibility of elastin peptide as a component for inhibiting wrinkle formation which was induced by photoaging.


Elastin peptide, Ultraviolet irradiation, Skin photoaging, Superoxide dismutase (SOD)


Zheng Yan, Haiyan Wang, Aiqing Liu, Hailong Yu, Bin Jiang, Zhimin Xu, Zhiguo Li, Effects of Elastin Peptide on Antioxidative Defence of Photoaging Mice. MEDS Public Health and Preventive Medicine (2022) Vol. 2: 53-58. DOI:


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