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Research Progress of Treating Infantile Anorexia from Liver and Spleen Based on Brain Gut Axis Theory

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DOI: 10.23977/medcm.2022.040105 | Downloads: 6 | Views: 239


Xiaojuan Sun 1, Yongxue Zhou 1


1 Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, Shanxi, China

Corresponding Author

Yongxue Zhou


Infantile anorexia is a common functional disease with anorexia as the main symptoms. The function of liver and spleen in traditional Chinese medicine is similar to that of brain gut axis in western medicine. Brain gut axis acts directly or indirectly on the central nervous system through microorganisms, brain gut peptides and other substances, regulates intestinal effector cells, and then regulates appetite. Traditional Chinese medicine discusses infantile anorexia from the liver and spleen. Studies on its related prescriptions have found that traditional Chinese medicine acts on the brain gut axis by affecting intestinal microorganisms, promoting the secretion of motilin and digestive enzymes, and then plays a therapeutic role. It has the same effect as the brain gut axis of Western medicine in the treatment of infantile anorexia. Although the brain gut axis theory does not belong to the category of traditional Chinese medicine, it can further prove the scientificity of traditional Chinese medicine in treating infantile anorexia from the theory of liver and spleen, and provide theoretical basis and relevant clinical experience for the treatment of infantile anorexia with the combination of Chinese and Western medicine.


Brain gut axis, Infantile anorexia, Liver and spleen


Xiaojuan Sun, Yongxue Zhou, Research on the Influencing Factors of Customer Loyalty in Tourist Destinations Based on Psychological Contract Theory. MEDS Chinese Medicine (2022) Vol. 4: 29-35. DOI:


[1] Van de Wouw M, Schellekens H, Dinan T G, et al. Microbiota-gut-brain axis: modulator of host metabolism and appetite[J]. The Journal of nutrition, 2017, 147(5): 727-745.
[2] Mack I, Cuntz U, Grämer C, et al. Weight gain in anorexia nervosa does not ameliorate the faecal microbiota, branched chain fatty acid profiles, and gastrointestinal complaints.[J].Sci Rep, 2016,6:26752.
[3] Fetissov SO. Role of the gut microbiota in host appetite control: bacterial growth to animal feeding behaviour. [J].Nat Rev Endocrinol,2017,13(1):11-25.
[4] Breton J, Legrand R, Akkermann K, et al. Elevated plasma concentrations of bacterial ClpB protein in patients with eating disorders.[J].Int J Eat Disord,2016,49(8):805-8.
[5] Thomas C, Gioiello A, Noriega L, et al.TGR5-mediated bile acid sensing controls glucose homeostasis[J].Cell Metab,2009,10(3):167-77.
[6] Yu SP. Clinical observation of XIEhuang Powder in the treatment of 100 cases of spleen and stomach dampness-heat type in children with anorexia [J]. Sichuan traditional Chinese medicine,2009,27(04):93-94.
[7] Baoku Li. Effect of Jianpi Xiaoshi Appetiser Decoction on children with anorexia [J]. Chinese journal of pharmaceutical sciences,2020,10(18):18-21+42.
[8] Jinhua Xu, Jinping Wang. Clinical effect of self-made jianpi yiqi decoction on children with anorexia [J]. Forum of primary care medicine,2020,24(31):4559-4560.
[9] Hou Zhang. Clinical study of yangyin Yunpi Prescription in the treatment of anorexia of spleen and stomach Yin deficiency in children [J]. Strait pharmacy,2019,31(06):155-156.
[10] Jianping Xu . Clinical observation of Yinshao Liujun Decoction in the treatment of anorexia in children with liver flourishing and spleen deficiency [D]. Yunnan University of Traditional Chinese Medicine,2018.
[11] Aydo ğ an F, Baykan Ş, Debelec Butuner B. Cytotoxic Activity of Sesquiterpenoids Isolated from Ferula tenuissima Hub [J]-Mor & Peşmen. Turk J Pharm Sci, 2019 (4) : 476-480.
[12] Aydo ğ an F, Baykan Ş, Debelec Butuner B. Cytotoxic Activity of Sesquiterpenoids Isolated from Ferula tenuissima Hub [J]-Mor & Peşmen. Turk J Pharm Sci, 2019 (4) : 476-480.
[13] Leilei Wu, Zhipeng He . Effects of Hawthorn water extract on 5-HT and 5-HT3R expression in colonic mucosa of rats with irritable bowel syndrome [J]. Journal of mudanjiang medical college,2011,32(04):6-9.
[14] Ming Shen, Xiaoqiang Huang, Meijiang Ruan. Improvement of gastrointestinal function in functional dyspepsia model rats by gizmo [J]. Fujian journal of traditional Chinese medicine,2019,50(04):35-37.
[15] Liang Li, Erdong Yuan, NaGou, et al. Inhibition of Helicobacter pylori and proliferation of GES-1 cells by water extracts from Poria cocosa [J]. Modern food science and technology,2019,35(10):19-24+147.
[16] Li Liu, Chun Xu, Ke Li et al. Study on ultrasonic extraction technology and antibacterial activity of polysaccharide from jiuzihe poria cocos [J]. Journal of agricultural science and technology,2016,17(12):2746-2750,2776.
[17] Hongxia Chen, Pei Li, Laying Xu. Effects of ethyl acetate extracts of Magnolia officinalis and Magnolia officinalis on gastrointestinal motility in mice [J]. Chinese journal of experimental formulae,2014,20(24):143-146.
[18] Huiru Hu, XiaorongWang,Liping Wu, et al. Differential proteomics and clinical significance of infantile Appetizer Zengshi Mixture in gastric antrum of anorexia rats [J]. Chinese Materia Medica Pharmacology & Clinical, 201,37(02):144-150.

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