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Effect of Xuanhuang ointment on SOD and MDA in local soft tissue of experimental acute traumatic hematoma

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DOI: 10.23977/phpm.2022.020205 | Downloads: 8 | Views: 634

Author(s)

Mingming Wang 1, Yan Cheng 2

Affiliation(s)

1 Shaanxi University of Traditional Chinese Medicine, Xian Yang 712046, China
2 Shaanxi Hospital of Traditional Chinese Medicine, Xi'an 710003, China

Corresponding Author

Yan Cheng

ABSTRACT

Objective: To observe the effect of Xuanhuang ointment on superoxide dismutase (SOD) and malondialdehyde (MDA) in local soft tissue of experimental acute soft tissue injury model rats. Methods: The acute soft tissue injury model of rats was established and randomly divided into Xuanhuang ointment group, safflower oil group and matrix ointment control group. Another 6 rats were taken as the normal group. In addition to the normal group, each group was given Xuanhuang ointment, safflower oil and matrix ointment to apply medicine to the injured part of rats respectively. Soft tissue samples were taken from the injured part on the first, third and fifth days after treatment. Some tissues were homogenized, and the contents of SOD and MDA in the homogenization solution were measured. Results: The content of MDA in local soft tissue injury in matrix ointment group was significantly higher than that in normal group (P < 0.01), and the content of SOD was lower than that in normal group (P < 0.01); Xuanhuang ointment group could inhibit the increase of MDA content in injured tissues and effectively promote the production of SOD (P < 0.01), and there was no significant difference compared with safflower oil group (P > 0.05). Conclusion: One of the effective mechanisms of Xuanhuang ointment in the treatment of acute soft tissue injury may be related to the fact that Xuanhuang ointment can effectively reduce the content of MDA and increase the activity of SOD in local soft tissue injury.

KEYWORDS

Acute soft tissue injury, Xuanhuang ointment, Superoxide dismutase, Malondialdehyde

CITE THIS PAPER

Mingming Wang, Yan Cheng, Effect of Xuanhuang ointment on SOD and MDA in local soft tissue of experimental acute traumatic hematoma. MEDS Public Health and Preventive Medicine (2022) Vol. 2: 30-35. DOI: http://dx.doi.org/10.23977/phpm.2022.020205.

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