Effect of Xuanhuang ointment on SOD and MDA in local soft tissue of experimental acute traumatic hematoma
DOI: 10.23977/phpm.2022.020205 | Downloads: 2 | Views: 114
Mingming Wang 1, Yan Cheng 2
1 Shaanxi University of Traditional Chinese Medicine, Xian Yang 712046, China
2 Shaanxi Hospital of Traditional Chinese Medicine, Xi'an 710003, China
Corresponding AuthorYan Cheng
Objective: To observe the effect of Xuanhuang ointment on superoxide dismutase (SOD) and malondialdehyde (MDA) in local soft tissue of experimental acute soft tissue injury model rats. Methods: The acute soft tissue injury model of rats was established and randomly divided into Xuanhuang ointment group, safflower oil group and matrix ointment control group. Another 6 rats were taken as the normal group. In addition to the normal group, each group was given Xuanhuang ointment, safflower oil and matrix ointment to apply medicine to the injured part of rats respectively. Soft tissue samples were taken from the injured part on the first, third and fifth days after treatment. Some tissues were homogenized, and the contents of SOD and MDA in the homogenization solution were measured. Results: The content of MDA in local soft tissue injury in matrix ointment group was significantly higher than that in normal group (P < 0.01), and the content of SOD was lower than that in normal group (P < 0.01); Xuanhuang ointment group could inhibit the increase of MDA content in injured tissues and effectively promote the production of SOD (P < 0.01), and there was no significant difference compared with safflower oil group (P > 0.05). Conclusion: One of the effective mechanisms of Xuanhuang ointment in the treatment of acute soft tissue injury may be related to the fact that Xuanhuang ointment can effectively reduce the content of MDA and increase the activity of SOD in local soft tissue injury.
KEYWORDSAcute soft tissue injury, Xuanhuang ointment, Superoxide dismutase, Malondialdehyde
CITE THIS PAPER
Mingming Wang, Yan Cheng, Effect of Xuanhuang ointment on SOD and MDA in local soft tissue of experimental acute traumatic hematoma. MEDS Public Health and Preventive Medicine (2022) Vol. 2: 30-35. DOI: http://dx.doi.org/10.23977/phpm.2022.020205.
 Muckart DJJ, Moodley M, Naidu AG, et al. Prediction of acute renal failure following soft-tissue injury using the venous bicarbonate concentration [J]. Journal of Trauma, 1992, 33(6): 813.
 Wang Xiangyu, Yu Zhiyong, Peng Rong, Miao yangjuan. Modified Fuyuan Huoxue Decoction Combined with sports trauma treatment machine in the treatment of sports soft tissue sprain [J] World Journal of traditional Chinese medicine, 2020,15 (03): 406-410.
 Weiler JM. Medical modifiers of sports injury. The use of nonsteroidal anti-inflammatory drugs (NSAIDs) in sports soft-tissue injury [J]. Clinics in Sports Medicine, 1992, 11(3): 625.
 Liu Junpeng. Treatment of acute soft tissue injury [J] Journal of Chengde Medical College, 2001, 18 (3): 257-258.
 Li Weixing Therapeutic effect of Xiaoyu Zhitong ointment on acute soft tissue injury in rats [J] Traditional Chinese medicine bone setting, 2000, 12 (11): 11-12.
 Li Chaoyan, Zhou Yuanyuan, Xin Qingfeng, et al Effects of Polygonatum Polysaccharide on superoxide dismutase, malondialdehyde and blood lipid in natural menopausal rats [J]. Chinese Journal of Gerontology, 2013; 33(24): 6215-6.
 Sagar S, Kallo IL, Kaul N, et al, Oxygen free radieals in essentials in hypertention. Mol Cell Biochem, 1992, 111: 103-108.
 Muzykantov VR.Tavgenting of soperoxide dismutase and catalase to vascular endothelilm, J Control Release, 2001, 71(1): 6-21.
 Zhang Xiaotian, Zheng Xiaoying Superoxide dismutase, an oxidative free radical scavenger, and diseases [J]. China public health, 2014; 30(10): 1349-52.