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Study Advance of Mirna in Hirschsprung's Disease

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DOI: 10.23977/medsc.2022.030112 | Downloads: 6 | Views: 594


Li Yuan 1, Tang Shaotao 1


1 Department of Pediatric Surgery, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430022, China

Corresponding Author

Tang Shaotao


MicroRNA (miRNA) is a small endogenous non-coding RNA and plays an important role in posttranscriptional gene regulation. Studies have shown that miRNA is closely related to various diseases including Hirschsprung's disease(HSCR). MiRNAs are mainly involved in the proliferation and migration of neural crest cells through target genes for the pathogenesis of Hirschsprung's disease. Some miRNAs are also significantly higher in plasma, which can serve as new noninvasive biomarkers for early screening and diagnosis of Hirschsprung's disease.


Mirna, Hirschsprung's disease, Pathogenesis, Biomarker


Li Yuan, Tang Shaotao, Study Advance of Mirna in Hirschsprung's Disease. MEDS Clinical Medicine (2022) Vol. 3: 65-68. DOI:


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