Education, Science, Technology, Innovation and Life
Open Access
Sign In

Study Advance of Mirna in Hirschsprung's Disease

Download as PDF

DOI: 10.23977/medsc.2022.030112 | Downloads: 6 | Views: 594

Author(s)

Li Yuan 1, Tang Shaotao 1

Affiliation(s)

1 Department of Pediatric Surgery, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430022, China

Corresponding Author

Tang Shaotao

ABSTRACT

MicroRNA (miRNA) is a small endogenous non-coding RNA and plays an important role in posttranscriptional gene regulation. Studies have shown that miRNA is closely related to various diseases including Hirschsprung's disease(HSCR). MiRNAs are mainly involved in the proliferation and migration of neural crest cells through target genes for the pathogenesis of Hirschsprung's disease. Some miRNAs are also significantly higher in plasma, which can serve as new noninvasive biomarkers for early screening and diagnosis of Hirschsprung's disease.

KEYWORDS

Mirna, Hirschsprung's disease, Pathogenesis, Biomarker

CITE THIS PAPER

Li Yuan, Tang Shaotao, Study Advance of Mirna in Hirschsprung's Disease. MEDS Clinical Medicine (2022) Vol. 3: 65-68. DOI: http://dx.doi.org/10.23977/medsc.2022.030112.

REFERENCES

[1] Nagy N, Goldstein AM. Enteric nervous system development: A crest cell's journey from neural tube to colon. Semin Cell Dev Biol 2017;66:94–106. https://doi.org/10/gbnbdf.
[2] Diposarosa R, Bustam NA, Sahiratmadja E, Susanto PS, Sribudiani Y. Literature review: enteric nervous system development, genetic and epigenetic regulation in the etiology of Hirschsprung's disease. Heliyon 2021;7:e07308. https://doi.org/10/gmjsrp.
[3] Nagy N, Guyer RA, Hotta R, Zhang D, Newgreen DF, Halasy V, et al. RET overactivation leads to concurrent Hirschsprung disease and intestinal ganglioneuromas. Development 2020;147:dev190900. https://doi.org/10/gnpdc2.
[4] Truch K, Arter J, Turnescu T, Weider M, Hartwig AC, Tamm ER, et al. Analysis of the human SOX10 mutation Q377X in mice and its implications for genotype-phenotype correlation in SOX10-related human disease. Hum Mol Genet 2018;27:1078–92. https://doi.org/10/gc446b.
[5] McCallion AS, Chakravarti A. EDNRB/EDN3 and Hirschsprung disease type II. Pigment Cell Res 2001;14:161–9. https://doi.org/10/drdx7b.
[6] Drabent P, Bonnard A, Guimiot F, Peuchmaur M, Berrebi D. PHOX2B Immunostaining: A Simple and Helpful Tool for the Recognition of Ganglionic Cells and Diagnosis of Hirschsprung Disease. Am J Surg Pathol 2020;44:1389–97. https://doi.org/10/gmkv7w.
[7] Sribudiani Y, Chauhan RK, Alves MM, Petrova L, Brosens E, Harrison C, et al. Identification of Variants in RET and IHH Pathway Members in a Large Family With History of Hirschsprung Disease. Gastroenterology 2018;155:118-129.e6. https://doi.org/10/gdx3cb.
[8] Ngan ES-W, Garcia-Barceló M-M, Yip BH-K, Poon H-C, Lau S-T, Kwok CK-M, et al. Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans. J Clin Invest 2011;121:3467–78. https://doi.org/10/ddgn8r.
[9] Jaroy EG, Acosta-Jimenez L, Hotta R, Goldstein AM, Emblem R, Klungland A, et al. "Too much guts and not enough brains": (epi)genetic mechanisms and future therapies of Hirschsprung disease - a review. Clin Epigenetics 2019;11:135. https://doi.org/10/gnxznd.
[10] Heuckeroth RO. Hirschsprung disease - integrating basic science and clinical medicine to improve outcomes. Nat Rev Gastroenterol Hepatol 2018;15:152–67. https://doi.org/10/gjhnpw.
[11] Lu TX, Rothenberg ME. MicroRNA. J Allergy Clin Immunol 2018;141:1202–7. https://doi.org/10/ghw8hn.
[12] Michlewski G, Cáceres JF. Post-transcriptional control of miRNA biogenesis. RNA 2019;25:1–16. https://doi.org/10/gjvgmg.
[13] Zhou S-S, Jin J-P, Wang J-Q, Zhang Z-G, Freedman JH, Zheng Y, et al. miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges. Acta Pharmacol Sin 2018;39:1073–84. https://doi.org/10/gdnr86.
[14] Ferragut Cardoso AP, Udoh KT, States JC. Arsenic-induced changes in miRNA expression in cancer and other diseases. Toxicol Appl Pharmacol 2020;409:115306. https://doi.org/10/gn9z6f.
[15] Li S, Wang S, Guo Z, Wu H, Jin X, Wang Y, et al. miRNA Profiling Reveals Dysregulation of RET and RET-Regulating Pathways in Hirschsprung's Disease. PLoS One 2016;11:e0150222. https://doi.org/10/gpbf3x.
[16] Lei H, Tang J, Li H, Zhang H, Lu C, Chen H, et al. MiR-195 affects cell migration and cell proliferation by down-regulating DIEXF in Hirschsprung's disease. BMC Gastroenterol 2014;14:123. https://doi.org/10/f58275.
[17] Tang W, Tang J, He J, Zhou Z, Qin Y, Qin J, et al. SLIT2/ROBO1-miR-218-1-RET/PLAG1: a new disease pathway involved in Hirschsprung's disease. J Cell Mol Med 2015;19:1197–207. https://doi.org/10/f7dkzp.
[18] Hong M, Li X, Li Y, Zhou Y, Li Y, Chi S, et al. Hirschsprung's disease: key microRNAs and target genes. Pediatr Res 2021. https://doi.org/10/gpbbvj.
[19] Chen G, Du C, Shen Z, Peng L, Xie H, Zang R, et al. MicroRNA-939 inhibits cell proliferation via targeting LRSAM1 in Hirschsprung’s disease. Aging (Albany NY) 2017;9:2471–9. https://doi.org/10/gpbbf3.
[20] Zhu D, Xie H, Li H, Cai P, Zhu H, Xu C, et al. Nidogen-1 is a common target of microRNAs MiR-192/215 in the pathogenesis of Hirschsprung's disease. J Neurochem 2015;134:39–46. https://doi.org/10/f7gbqx.
[21] Tang W, Qin J, Tang J, Zhang H, Zhou Z, Li B, et al. Aberrant reduction of MiR-141 increased CD47/CUL3 in Hirschsprung's disease. Cell Physiol Biochem 2013;32:1655–67. https://doi.org/10/gn92rq.
[22] Sharan A, Zhu H, Xie H, Li H, Tang J, Tang W, et al. Down-regulation of miR-206 is associated with Hirschsprung disease and suppresses cell migration and proliferation in cell models. Sci Rep 2015;5:9302. https://doi.org/10/gpbbrn.
[23] Li H, Li B, Zhu D, Xie H, Du C, Xia Y, et al. Downregulation of lncRNA MEG3 and miR-770-5p inhibit cell migration and proliferation in Hirschsprung's disease. Oncotarget 2017;8:69722–30. https://doi.org/10/gbpdf4.
[24] Wang G, Guo F, Wang H, Liu W, Zhang L, Cui M, et al. Downregulation of microRNA-483-5p Promotes Cell Proliferation and Invasion by Targeting GFRA4 in Hirschsprung’s Disease. DNA Cell Biol 2017;36:930–7. https://doi.org/10/gckrtf.
[25] Ambartsumyan L, Smith C, Kapur RP. Diagnosis of Hirschsprung Disease. Pediatr Dev Pathol 2020;23:8–22. https://doi.org/10/gjjrpw.
[26] Tang W, Li H, Tang J, Wu W, Qin J, Lei H, et al. Specific serum microRNA profile in the molecular diagnosis of Hirschsprung’s disease. J Cell Mol Med 2014;18:1580–7. https://doi.org/10/f6g3w5.

Downloads: 3870
Visits: 167017

Sponsors, Associates, and Links


All published work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2016 - 2031 Clausius Scientific Press Inc. All Rights Reserved.