Education, Science, Technology, Innovation and Life
Open Access
Sign In

Correlation of bone mineral density in elderly patients with type 2 diabetes mellitus

Download as PDF

DOI: 10.23977/medsc.2022.030104 | Downloads: 10 | Views: 633

Author(s)

Huanna Li 1, Yuanshan Tang 2, Rong Hui 1, Yu Gu 1, Nan Zhang 1

Affiliation(s)

1 Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi 712046, China
2 Xi'an Hospital of Traditional Chinese Medicine, Xi'an, Shaanxi 710016, China

Corresponding Author

Yuanshan Tang

ABSTRACT

Objective to explore the relationship between glycosylated hemoglobin (HbA1c), hemoglobin (Hb) and bone mineral density in elderly patients with type 2 diabetes mellitus. Methods 154 elderly patients with type 2 diabetes mellitus in the inpatient department of Xi'an Hospital of Traditional Chinese Medicine were selected, and their HbA1c was measured. According to the HbA1c level, they were divided into two groups: group A (73 cases with HbA1c < 7.0%) and group B (81 cases with HbA1c≥7.0%). Age, body mass index (BMI), hemoglobin (Hb) and bone mineral density (BMD) were measured respectively. Results There was no statistically significant difference between HbA1c and bone mineral density in elderly T2DM patients in group A (P>0.05), but there was a statistically significant difference between HbA1c and bone mineral density in group B (P<0.05). According to the analysis of related factors of bone mineral density, there was a correlation between bone mineral density and Hb, BMI and age, and the difference was statistically significant (P<0.05). It is discussed that when HbA1c≥7.0% in elderly T2DM patients, the bone density T value obviously decreases, which increases the risk of osteoporosis, and there is a positive correlation between bone density T value and Hb and BMI. The decrease of Hb and BMI may increase the risk of osteoporosis.

KEYWORDS

Elderly T2DM, glycosylated hemoglobin, hemoglobin, bone density

CITE THIS PAPER

Xinxin Fan, Pengguang Xu, Nan Zhang, Correlation of bone mineral density in elderly patients with type 2 diabetes mellitus. MEDS Clinical Medicine (2022) Vol. 3: 20-24. DOI: http://dx.doi.org/10.23977/medsc.2022.030104.

REFERENCES

[1] Guo Caixia. Probe into the relationship between type 2 diabetes mellitus and osteoporosis [J]. Chinese Modern Medicine Application, 2018, 12 (20): 38-39.
[2] Chen Haozhu, Zhong Nanshan, Lu Zaiying, et al. Internal Medicine [M]. Beijing: People's Health Publishing House, 2013: 860-865.
[3] Yu Zhou, Qiu Jian, et al. Study on the correlation between glycated hemoglobin and bone mineral density in patients with type 2 diabetes mellitus [J]. Chinese journal of clinical healthcare. 2020, 23(05): 621-624.
[4] Wang Jun, Shu Yiqiong. Research progress on pathogenesis of osteoporosis in type 2 diabetes mellitus [J]. Clinical journal of traditional Chinese medicine, 2012, 24 (2): 183.
[5] Azuma K. Therapeutic considerations on secondary osteoporosis caused by diabetes mellitus [J]. Clin Calcium, 2009, 19(9): 1345-1352.
[6] Chu Shufang, Zhao Hengxia, Liu Deliang, et al. Prevention and treatment of diabetic osteoporosis with traditional Chinese medicine [J]. World Traditional Chinese Medicine, 2018, 13(7): 1804-1808.
[7] Lei Yinghong, Chen Hui, Liu Ju. Correlation between bone mineral density and inflammatory factors in elderly patients with type 2 diabetes mellitus [J]. Chinese Journal of Osteoporosis, 2017, 23 (2): 213-215.
[8] Ma Yuanzheng, Wang Yipeng, Liu Qiang, et al. Guidelines for diagnosis and treatment of osteoporosis in the elderly in China (2018) [J]. Chinese Journal of Osteoporosis, 2018, 24 (12): 1541-1565.
[9] GUTZWILLER J P, RICHTERICH J P, STANGA Z, et al. Osteoporosis, diabetes, and hypertension are major risk factors for mortality in older adults: an intermediate report on a prospective survey of 1467 community-dwelling elderl y healthy pensioners in Switzerland [J]. BMC Geriatrics, 2018, 18(1): 115.
[10] SALAMAT A H, SALAMAT M R, JANGHORBANI M. High bone mineral density and osteoporosis in men with type 2 diabetes referred for dual-energy X-Ray absorptiometry scan in Isfahan, Iran [J]. Advan Biol Res, 2014, 8 (5): 212-220.
[11] Wang Hanxiao. Study on the pathogenesis of diabetes mellitus complicated with osteoporosis [J]. Guide of china medicine, 2018, 16 (21): 19-20.
[12] Kanazawa I. Interaction between bone and glucose metabolism [J]. Endocr J, 2017, 64(11): 1043-1053.
[13] Fu Wenping. Correlation between advanced glycation end products and bone metabolism and bone density in patients with type 2 diabetes mellitus [J]. Chinese General Medicine. 2013, 16(2): 154-157.
[14] Sun Mingjin, Cai Junwei, Xuefeng Li, et al. Study on the relationship between insulin-like growth factor -1 and bone mineral density in patients with type 2 diabetes mellitus. Guangxi Medical Science, 2008, 30(6): 793.
[15] Hu Caihong, Xu Kun, Sun Jing, et al. Investigation and analysis of osteoporosis incidence and bone metabolism characteristics in patients with type 2 diabetes mellitus [J]. Journal of Preventive Medicine of PLA, 2017, 35, (10): 1221-1223.
[16] Fu Mengfei, Li Huan, et al. Meta-analysis of risk factors of osteoporosis in Chinese people with type 2 diabetes mellitus [J]. Journal of Huazhong University of Science and Technology .2021, 50 (01): 94-100.
[17] GEVA M, SHLOMAI G, BURKOVICH A, et al. The association between fasting plasma glucose and glycated hemoglobin in the prediabetes range and future development of hypertension [J]. Cardiovasc Diabetol, 2019, 18(1): 53.
[18] Sun Guoqiang, Guo Qingsheng, Wen Jiuquan. Influence of height, weight and BMI on bone mineral content of normal middle-aged and elderly people in Liaoning [J]. Chinese Journal of Osteoporosis, 2003, 9(1): 35-36.
[19] ZHANG LL, MAO X M, YUN H U, et al. The changes in the bone mineral density and the associated factors in male T2DM patients [J]. Chin J Diabetes, 2013, 11(21): 1008-1010.
[20] Korkmaz U, Korkmaz N, Yazici S, et al. Anemia as a risk factor for low bone mineral density in postmenopausal Turkish women [J]. Eur J Intern Med, 2012, 23(2): 154-158.
[21] Xiu Shuangling, Sun Lina, et al. Correlation between hemoglobin and osteoporosis in elderly patients with type 2 diabetes mellitus [J]. Chinese Journal of Osteoporosis, 2021, 27 (01), 36-39.
[22] Wu LY, Yang TC, Kuo SW, et al. Correlation between bone mineral density and plasma lipids in Taiwan [J]. Endocr Res, 2003, 29(3): 317-325.

Downloads: 3870
Visits: 166987

Sponsors, Associates, and Links


All published work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2016 - 2031 Clausius Scientific Press Inc. All Rights Reserved.