Application of Biotransformation Technology in Pharmaceutical
DOI: 10.23977/medcm.2022.040101 | Downloads: 9 | Views: 364
Jiang Lingmin 1, Luo Yuefang 2
1 Changde Vocational Technical College, Changde, Hunan, 415000, China
2 Xintian County Market Supervision Administration, Yongzhou, Hunan, 425700, China
Corresponding AuthorJiang Lingmin
The use of exogenous natural or synthetic organic compounds as a substrate, added to the growing state in the biological system or enzyme system, under appropriate conditions for culture, the substrate and the enzyme in the biological system interaction, resulting in Structure change, this process known as biotransformation, also known as biocatalysis, its essence is the enzyme catalytic reaction. Compared with chemical catalysts, biotransformation with high specificity, conditions are mild, selective, less by-product and do not pollute the environment and so on. In recent years, biotransformation to structural modification of the chemical constituents of traditional Chinese medicine, novel structure, better lead compounds can be obtained, or are valuable intermediates.Biological transformation to the pharmaceutical industry in drug research and a series of ground-breaking application creates enormous health and economic value, has become an effective way to develop new drugs.
KEYWORDSBiotransformation, Suspension culture, Secondary metabolism, Microbial transformation, Enzymatic conversion
CITE THIS PAPER
Jiang Lingmin, Luo Yuefang, Application of Biotransformation Technology in Pharmaceutical. MEDS Chinese Medicine (2022) Vol. 4: 1-7. DOI: http://dx.doi.org/10.23977/medcm.2022.040101.
 Funes-Collado V, Morell-Garcia A, Rubio R, et al. Study of selenocompounds from selenium-enriched culture of edible sprouts. Food Chem, 2013,141(4):3738-43.
 Mao Z, Sun W, Fu L, et al. Natural dibenzo-alpha-pyrones and their bioactivities. Molecules, 2014,19(4):5088-108.
 Wang Y, Chen S, Yu O. Metabolic engineering of flavonoids in plants and microorganisms. Appl Microbiol Biotechnol, 2011,91(4):949-56.
 Cheng XD, Wei MG. Profiling the Metabolism of Astragaloside IV by Ultra Performance Liquid Chromatography Coupled with Quadrupole/Time-of-Flight Mass Spectrometry. Molecules, 2014,19(11):18881-96.
 Gao F, Zhang JM, Wang ZG, et al. Biotransformation, a promising technology for anti-cancer drug development. Asian Pac J Cancer Prev, 2013,14(10):5599-608.
 Tang YJ, Zhao W, Li HM. Novel tandem biotransformation process for the biosynthesis of a novel compound, 4-(2,3,5,6-tetramethylpyrazine-1)-4'-demethylepipodophyllotoxin. Appl Environ Microbiol, 2011,77(9):3023-34.
 Zhang SL, Zhang TZ, Yang SH. [Establishment of culture system of Silybum marianum hairy roots and determination of silybin]. Zhongguo Zhong Yao Za Zhi, 2014,39(11):2005-10.
 Singh A, Srivastava S, Chouksey A, et al. Expression of Rabies Glycoprotein and Ricin Toxin B Chain (RGP-RTB) Fusion Protein in Tomato Hairy Roots: A Step Towards Oral Vaccination for Rabies. Mol Biotechnol, 2014.
 Patra N, Srivastava AK. Enhanced production of artemisinin by hairy root cultivation of Artemisia annua in a modified stirred tank reactor. Appl Biochem Biotechnol, 2014,174(6):2209-22.
 Sharifi S, Sattari T N, Zebarjadi A, et al. The influence of Agrobacterium rhizogenes on induction of hairy roots and ß-carboline alkaloids production in Tribulus terrestris L[J]. Physiology and Molecular Biology of Plants, 2014, 20(1): 69-80.
 Khanpour-Ardestani N, Sharifi M, Behmanesh M. Establishment of callus and cell suspension culture of Scrophularia striata Boiss.: an in vitro approach for acteoside production. Cytotechnology, 2014.
 Chen RD, Liu X, Zou JH, et al. [Regulation of syringin, chlorogenic acid and 1,5-dicaffeoylquinic acid biosynthesis in cell suspension cultures of Saussurea involucrata]. Zhongguo Zhong Yao Za Zhi, 2014,39(12):2275-80.
 De Vijlder T, Valkenborg D, Dewaele D, et al. A generic approach for “shotgun” analysis of the soluble proteome of plant cell suspension cultures. J Chromatogr B Analyt Technol Biomed Life Sci, 2015,974:48-56.
 Cetin ES, Babalik Z, Hallac-Turk F, et al. The effects of cadmium chloride on secondary metabolite production in Vitis vinifera cv. cell suspension cultures. Biol Res, 2014,47(1):47.
 Mizzotti C, Ezquer I, Paolo D, et al. SEEDSTICK is a Master Regulator of Development and Metabolism in the Arabidopsis Seed Coat. PLoS Genet, 2014,10(12):e1004856.
 Gandhi SG, Mahajan V, Bedi YS. Changing trends in biotechnology of secondary metabolism in medicinal and aromatic plants. Planta, 2014.
 Cires S, Alvarez-Roa C, Heimann K. First use of the WAVE disposable rocking bioreactor for enhanced bioproduct synthesis by N -fixing cyanobacteria. Biotechnol Bioeng, 2014.
 Syklowska-Baranek K, Pilarek M, Cichosz M, et al. Liquid perfluorodecalin application for in situ extraction and enhanced naphthoquinones production in Arnebia euchroma cell suspension cultures. Appl Biochem Biotechnol, 2014,172(5):2618-27.
 Loc NH, Nhat NT. Production of asiaticoside from centella (Centella asiatica L. Urban) cells in bioreactor. Asian Pac J Trop Biomed, 2013,3(10):806-10.
 Shao L, Zhao SJ, Cui TB, et al. 2,3,5,4'- tetrahydroxystilbene-2-O-beta-D-glycoside biosynthesis by suspension cells cultures of Polygonum multiflorum Thunb and production enhancement by methyl jasmonate and salicylic acid. Molecules, 2012,17(2):2240-7.
 Chen Y, Wang Y, Sun L, et al. [Fermentation transformed ginsenoside by Lactobacillus plantarum]. Zhongguo Zhong Yao Za Zhi, 2014,39(8):1435-40.
 Ming Q, Su C, Zheng C, et al. Elicitors from the endophytic fungus Trichoderma atroviride promote Salvia miltiorrhiza hairy root growth and tanshinone biosynthesis. J Exp Bot, 2013,64(18):5687-94.
 Zhang M, Gao W, Wang XJ. [Medicinal plant hairy roots generating and their applications]. Zhongguo Zhong Yao Za Zhi, 2014,39(11):1956-60.
 Lee M E, Aswani A, Han A S, et al. Expression-level optimization of a multi-enzyme pathway in the absence of a high-throughput assay[J]. Nucleic acids research, 2013: gkt809.
 Tusevski O, Petreska SJ, Stefova M, et al. Phenolic profile of dark-grown and photoperiod-exposed Hypericum perforatum L. Hairy root cultures. ScientificWorldJournal, 2013,2013:602752.
 Fazal H, Abbasi BH, Ahmad N. Optimization of Adventitious Root Culture for Production of Biomass and Secondary Metabolites in Prunella vulgaris L. Appl Biochem Biotechnol, 2014,174(6):2086-95.
 Sivanandhan G, Arun M, Mayavan S, et al. Optimization of elicitation conditions with methyl jasmonate and salicylic acid to improve the productivity of withanolides in the adventitious root culture of Withania somnifera (L.) Dunal. Appl Biochem Biotechnol, 2012,168(3):681-96.
 Li Z, Zhang L, He W, et al. Astragalus membranaceus inhibits peritoneal fibrosis via monocyte chemoattractant protein (MCP)-1 and the transforming growth factor-尾1 (TGF-尾1) pathway in rats submitted to peritoneal dialysis[J]. International journal of molecular sciences, 2014, 15(7): 12959-12971.
 Thwe AA, Kim Y, Li X, et al. Accumulation of Phenylpropanoids and Correlated Gene Expression in Hairy Roots of Tartary Buckwheat under Light and Dark Conditions. Appl Biochem Biotechnol, 2014,174(7):2537-47.
 Park JW, Park SR, Han AR, et al. Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A. J Nat Prod, 2011,74(5):1272-4.
 Khan NT, Bibi M, Yousuf S, et al. Synthesis of some potent immunomodulatory and anti-inflammatory metabolites by fungal transformation of anabolic steroid oxymetholone. Chem Cent J, 2012,6(1):153.
 Hosseinabadi T, Vahidi H, Nickavar B, et al. Fungal Transformation of Androsta-1,4-diene-3,17-dione by Aspergillus brasiliensis. Daru, 2014,22(1):71.
 Lin XH, Cao MN, He WN, et al. Biotransformation of 20(R)-panaxadiol by the fungus Rhizopus chinensis. Phytochemistry, 2014,105:129-34.
 Quan LH, Kim YJ, Li GH, et al. Microbial transformation of ginsenoside Rb1 to compound K by Lactobacillus paralimentarius. World J Microbiol Biotechnol, 2013,29(6):1001-7.
 Hou JG, Xue JJ, Sun MQ, et al. Highly selective microbial transformation of major ginsenoside Rb1 to gypenoside LXXV by Esteya vermicola CNU120806. J Appl Microbiol, 2012,113(4):807-14.
 Liang M, Chen M, Liu X, et al. Bioconversion of D-galactose to D-tagatose: continuous packed bed reaction with an immobilized thermostable L-arabinose isomerase and efficient purification by selective microbial degradation. Appl Microbiol Biotechnol, 2012,93(4):1469-74.
 De Winter K, Soetaert W, Desmet T. An imprinted cross-linked enzyme aggregate (iCLEA) of sucrose phosphorylase: combining improved stability with altered specificity[J]. International journal of molecular sciences, 2012, 13(9): 11333-11342.