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To explore the mechanism of huangqi guizhi wuwu decoction in the treatment of rheumatoid arthritis based on network pharmacology

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DOI: 10.23977/medsc.2021.020218 | Downloads: 6 | Views: 705

Author(s)

Wenchao Dong 1, Qiang Zan 1

Affiliation(s)

1 Affiliated Hospital of Shaanxi University of traditional Chinese medicine, xianyang 712000, Shaanxi, China

Corresponding Author

Qiang Zan

ABSTRACT

Objective: To explore and analyze the mechanism of huangqi guizhi wuwu decoction in the treatment of RA by network pharmacology, providing a potentially effective research direction for more basic and clinical studies. Methods: using TCMSP huangqi guizhi wuwu decoction of the effective components of each Chinese medicine and its corresponding target to screen; The RA targets were screened in Genecards, OMIM and Drugbank databases. The therapeutic target of huangqi guizhi wuwu decoction for RA was obtained by using Venny2.1 platform. STRING 11.0 was used to construct the intersection target PPI network and Cytoscape3.7.2 software was used to generate the TCM - compound component - target - disease network diagram. The Metascape platform was used to carry out GO enrichment analysis and KEGG pathway enrichment analysis on the intersection targets. The first 20 pathways of KEGG pathway enrichment analysis were screened and the "target-pathway" network diagram was constructed through Cytoscape3.7.2.Results: huangqi guizhi wuwu decoction on 26 effective active ingredient of RA and 123 targets, such as propagated, IL6, AKT1, TNF, VEGFA, TP53, participated in the AGE of diabetes complications - RAGE signaling pathways, cancer related pathways, the nf-kappa B signaling pathway and PI3K - Akt signaling pathways, such as endocrine resistance to multiple pathways. Conclusion: huangqi guizhi wuwu decoction may be used to treat RA by inhibiting inflammatory response, regulating immune function and regulating apoptosis pathways.

KEYWORDS

Huangqi guizhi wuwu soup, Rheumatoid arthritis, Network pharmacology, Targets, Signal pathway

CITE THIS PAPER

Wenchao Dong, Qiang Zan. To explore the mechanism of huangqi guizhi wuwu decoction in the treatment of rheumatoid arthritis based on network pharmacology. MEDS Clinical Medicine (2021) 2: 94-103. DOI: http://dx.doi.org/10.23977/medsc.2021.020218

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