Effect of Qinghuo Anshen Decoction on Insomnia Rats with Qi-Stagnation Type
DOI: 10.23977/medsc.2021.020217 | Downloads: 5 | Views: 576
Yanxia Hu 1, Duofeng Zhu 2
1 Shaanxi University of Traditional Chinese Medicine, Shaanxi 712046
2 Pingliang Traditional Chinese Medicine, Orthopedics and Traumatology Hospital, Gansu, 744000
Corresponding AuthorYanxia Hu
Purpose Observe the effect of Qinghuo Anshen Decoction on the expression of 5-HT, Glu and GABA in qi-stagnation insomnia rats. Methods Sixty rats were divided into: peace quality control group, peace quality Qinghuo Anshen decoction group, qi depression quality control group, Qiyu quality Qinghuo Anshen decoction group. After treatment, the serum 5-HT, Glu and GABA contents of rats were detected. Results After the intervention of Qinghuo Anshen Decoction: 5-HT in the qi-stagnation insomnia treatment group was significantly higher than that in the qi-stagnation insomnia model group, P<0.01, and the 5-HT in the peaceful insomnia treatment group was significantly higher than that in the peaceful insomnia model group, P<0.01 , Indicating that Qinghuo Anshen Decoction is effective for qi-stagnation constitutional insomnia and calming and qualitative insomnia; comparison of 5-HT between the qi-stagnation insomnia treatment group and the peaceful insomnia treatment group was found to be P>0.05, but due to the qi-stagnation insomnia rat serum before treatment 5-HT is lower than normal insomnia, which proves that Qinghuo Anshen Decoction is better than peaceful insomnia. Glu and GABA were compared between the two groups. There was no significant difference in serum GLU and GABA before and after the insomnia model (P>0.05), indicating that the physique model had little effect on the content of GLU and GABA in the rat serum. Glu and GABA Comparing the two groups, the serum GLU content of rats in each group was significantly higher than that before insomnia modeling (P<0.01); the GABA content in serum of rats in each group was significantly lower than that before insomnia modeling (P<0.01); It shows that Qinghuo Anshen Decoction is effective in improving insomnia in Qi-stagnation insomnia rats and peaceful rats. Conclusion Qinghuo Anshen Decoction can improve insomnia by reducing serum Glu and increasing GABA and 5-HT content. 5-HT can also improve qi stagnation physique. Qinghuo Anshen Tang is effective in treating qi stagnation insomnia rat model.
KEYWORDSQinghuo Anshen Decoction, insomnia, 5-HT, Glu, GABA
CITE THIS PAPER
Yanxia Hu, Duofeng Zhu. Effect of Qinghuo Anshen Decoction on Insomnia Rats with Qi-Stagnation Type. MEDS Clinical Medicine (2021) 2: 86-93. DOI: http://dx.doi.org/10.23977/medsc.2021.020217
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