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Mechanism of acupuncture in the treatment of post-stroke depression

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DOI: 10.23977/medsc.2021.020213 | Downloads: 5 | Views: 669


Yingchun Xiao 1, Jianrong Hui 1,2, Pu Yang 1


1 College of Acupuncture & Massage, Shaanxi University of Chinese Medicine, Xixian New Area 712046, China
2 Shaanxi Key Laboratory of Acupuncture & Medicine, Xixian New Area 712046, China

Corresponding Author

Jianrong Hui


Post-stroke depression is depression secondary to stroke, which is mainly characterized by mood disorders such as pessimism and depression. Its bad mood seriously affects the patients' daily life, social activities and neurological function recovery, and brings trouble and pain to the patients and their families. A large number of clinical literature studies have shown that acupuncture treatment can effectively improve limb function and depression symptoms of stroke patients, but the mechanism of acupuncture treatment is still unclear. The author through the retrospective analysis in recent five years the mechanism of the relevant literature found that acupuncture play to the role of the antidepressant mechanism mainly with acupuncture dysregulation of neurotransmitter content, inhibiting inflammatory cytokines secretion, increase neurotrophic growth factor protein content, lower hippocampal neuron apoptosis, regulate signaling pathways related protein expression, inhibition of the hypothalamus-pituitary-adrenal axis hypersecretion, so as to provide guidance for clinical treatment.


Post stroke depression, acupuncture, mechanism research, review


Yingchun Xiao, Jianrong Hui, Pu Yang. Mechanism of acupuncture in the treatment of post-stroke depression. MEDS Clinical Medicine (2021) 2: 66-71. DOI:


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