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Correlation between Expression Level of Serum miRNAs and SSNHL

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DOI: 10.23977/medsc.2021.020208 | Downloads: 5 | Views: 718


Zile Wang 1, Hongsi Niu 2, Yong Tang 3


1 Kunming Medical University, Kunming, China
2 Yan’an Hospital Affiliated of Kunming Medical University, Kunming, China
3 First Affiliated Hospital of Kunming Medical University, Kunming, China

Corresponding Author

Yong Tang


Objective: To study the correlation between the serum expression levels of miR-143 and miR-145 and the incidence of SSNHL. Methods: 20 cases of SSNHL were collected as the experimental group, and 20 cases of normal hearing were collected as the control group. The expression levels of miR-143 and miR-145 in serum were detected by real-time fluorescence quantitative PCR method, and the t-test and Logistic regression analysis were used for statistical analysis. Results: The expression levels of serum miR-143 and miR-145 in SSNHL group were lower than those in the control group, and the differences were statistically significant (P < 0.05). Conclusion: The expression levels of miR-143 and miR-145 in serum were highly correlated with the incidence of SSNHL.


SSNHL; miRNAs, Real-time fluorescence quantitative PCR


Zile Wang, Hongsi Niu, Yong Tang. Correlation between Expression Level of Serum miRNAs and SSNHL. MEDS Clinical Medicine (2021) 2: 34-41. DOI:


[1] Kim SY, Song YS, Wee JH, et al. (2020) Association between SSNHL and Thyroid Diseases. Int J Environ Res Public Health, 17(22):8419. 
[2] Rhee TM, Hwang D, Lee JS, et al. (2018) Addition of Hyperbaric Oxygen Therapy vs Medical Therapy Alone for Idiopathic Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-analysis. JAMA Otolaryngol Head Neck Surg, 144(12):1153-1161. 
[3] Chen S, Zhao M, Qiu J. (2019) Acupuncture for the treatment of sudden sensorineural hearing loss: A systematic review and meta-analysis: Acupuncture for SSNHL. Complement Ther Med, 42:381-388.
[4] Chen L, Heikkinen L, Wang C, et al. (2019) Trends in the development of miRNA bioinformatics tools. Brief Bioinform, 20(5):1836-1852.
[5] Lu TX, Rothenberg ME. (2018) MicroRNA. J Allergy Clin Immunol, 141(4):1202-1207. 
[6] Ferrante M, Conti GO. (2017) Environment and Neurodegenerative Diseases: An Update on miRNA Role. Microrna, 6(3):157-165. 
[7] Xie S, Ning H, She Y, et al. (2020) Effect of systemic lupus erythematosus and rheumatoid arthritis on sudden sensorineural hearing loss. Laryngoscope, 130(10):2475-2480. 
[8] Mom T, Gilain L, Avan P. (2008) L'ischémie cochléaire: des données fondamentales aux espoirs cliniques [Cochlear ischemia: from fundamental data to clinical hope]. Ann Otolaryngol Chir Cervicofac, 125(6):301-8. French. 
[9] Kanzaki S, Sakagami M, Hosoi H, et al. (2014) High fibrinogen in peripheral blood correlates with poorer hearing recovery in idiopathic sudden sensorineural hearing loss. PLoS One, 9(8): e104680.
[10] Guo Y, Zhang C, Du X, et al. (2005) Morphological and functional alterations of the cochlea in apolipoprotein E gene deficient mice. Hear Res, 208(1-2):54-67. 
[11] Zhu Y, Xian X, Wang Z, et al. (2018) Research Progress on the Relationship between Atherosclerosis and Inflammation. Biomolecules. 8(3):80.
[12] Vacante F, Denby L, Sluimer JC, et al. (2019) The function of miR-143, miR-145 and the MiR-143 host gene in cardiovascular development and disease. Vascul Pharmacol, 112:24-30. 
[13] Cordes KR, Sheehy NT, White MP, et al. (2009) miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature, 460(7256):705-10. 
[14] Lovren F, Pan Y, Quan A, et al. (2012) MicroRNA-145 targeted therapy reduces atherosclerosis. Circulation, 126(11 Suppl 1): S81-90. 
[15] Wei YS, Xiang Y, Liao PH, et al. (2016) An rs4705342 T>C polymorphism in the promoter of miR-143/145 is associated with a decreased risk of ischemic stroke. Sci Rep, 6:34620. 
[16] Liu K, Xuekelati S, Zhang Y, et al. (2017) Expression levels of atherosclerosis-associated miR-143 and miR-145 in the plasma of patients with hyperhomocysteinaemia. BMC Cardiovasc Disord, 17(1):163.
[17] Passamonti SM, Di Berardino F, Bucciarelli P, et al. (2015) Risk factors for idiopathic sudden sensorineural hearing loss and their association with clinical outcome. Thromb Res, 135(3):508-512. 
[18] Fichtlscherer S, De Rosa S, Fox H, et al. (2010) Circulating microRNAs in patients with coronary artery disease. Circ Res, 107(5):677-84. 

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