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Analysis of the Influence of Clinical Symptoms on the Results of Tandem Mass Spectrometry

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DOI: 10.23977/medcm.2021.030232 | Downloads: 2 | Views: 307

Author(s)

Yifei liu 1

Affiliation(s)

1 Sichuan Haosi Muke Medical Laboratory Co., Ltd, Nanchong, Sichuan, 637500, China

Corresponding Author

Yifei liu

ABSTRACT

Objective To collect the basic clinical symptom data of NICU from 2018 to 2019, and to explore the influence of clinical symptoms on the positive results of neonatal tandem mass spectrometry screening. Methods After the informed consent of the parents of the newborn, the basic symptoms of the newborn were collected by the self-administered questionnaire method, sorted out by excel2013, and analyzed by spss19.0. Results Among 720 NICU newborns, 134 were positive. The positive rate of screening was 18.61%. There were 5 kinds of confirmed diseases, 8 cases in total, the rate of diagnosis was 1.11%. 447 male newborns were screened, the positive rate was 19.24%; 273 female newborns were screened, the positive rate was 17.58%. There was no significant difference between the male and female groups by chi square test. In this study, 412 newborns were screened at 2-7 days, with a positive rate of 20.63%; 236 newborns at 8-28 days, with a positive rate of 17.80%; 72 newborns at more than 28 days, with a positive rate of 9.72%. There was no significant difference between groups by chi square test. In this study, 64 normal newborns were screened, the positive rate was 23.44%; 256 premature infants were screened, the positive rate was 7.81%. The difference between the preterm and the normal group was statistically significant by chi square test. There was no significant difference between other factors group and normal control group. Conclusion The positive rate of tandem mass spectrometry screening of neonates with clinical symptoms in NICU is significantly higher than that of normal newborns. Gender and three months have little influence on the results of tandem mass spectrometry, and preterm infants have influence on the results of tandem mass spectrometry. Special attention should be paid to the results of the screening of preterm infants.

KEYWORDS

Newborn, Tandem mass spectrometry, Screening positive rate, Influencing factors

CITE THIS PAPER

Yifei liu, Analysis of the Influence of Clinical Symptoms on the Results of Tandem Mass Spectrometry. MEDS Chinese Medicine (2021) 3: 156-160. DOI: http://dx.doi.org/10.23977/medcm.2021.030232

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