Education, Science, Technology, Innovation and Life
Open Access
Sign In

The Better Safety of Acupuncture as a Complementary Therapy for Sepsis

Download as PDF

DOI: 10.23977/medcm.2021.030231 | Downloads: 1 | Views: 307


Heng Wang 1, Buqing Fu 1, Menglan Li 1, Jun Luo 1, Wei Jiang 1


1 Department of Laboratory, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China

Corresponding Author

Heng Wang


Objectives: Sepsis is a physiological, pathological, and biochemical syndrome caused by infection. The application of acupuncture as a complementary therapy for treating sepsis patients remains controversial. Our objective was to organize the relevant articles to assess the efficacy and safety of acupuncture as a complementary therapy for sepsis. Materials and methods: PubMed, the Cochrane Central Register of Controlled Trials, EMBASE, CNKI, Wan Fang Data, VIP database and TCM Literature Analysis and Retrieval Database were searched for randomized studies that compared acupuncture as a complementary therapy with conventional treatment for sepsis patients. The odds ratios (ORs), with 95% CI, was calculated by using a corresponding effects model for continuous data, according to the value of I2. Meta-analysis was performed by RevMan 5.3 software. Results: A total of eleven articles were included in our study. On comparing the clinical indexes, the acupuncture as a complementary therapy group was found to be better than the conventional treatment group in 28-day mortality [OR=0.61, 95%CI (0.36,1.04), P=0.07], APACHE II score at 7th day [MD=−3.36, 95%CI (−4.30, −2.41), P<0.00001],concentrations of procalcitonin (PCT) [MD=−2.23, 95%CI (−3.33, −1.13), P<0.0001] and TNF-α [MD=-14.86, 95%CI (−23.74, −5.97), P=0.001] at 7th day.However, there was no significant difference between the two groups about the CD8+ T cells count [MD=0.36, 95%CI (−1.57,2.29), P=0.71]. Conclusion: Based on the current evidence, acupuncture as a complementary therapy treatment had better clinical safety features than the conventional treatment. For those indicators with a small amount of data, a greater number of randomized, high-quality controlled trials should be conducted in order to further verify the findings.


Acupuncture, Sepsis, Systematic review


Heng Wang, Buqing Fu, Menglan Li, Jun Luo, Wei Jiang, The Better Safety of Acupuncture as a Complementary Therapy for Sepsis. MEDS Chinese Medicine (2021) 3: 151-155. DOI:


[1] Li HF, Hu GQ, Liu WW. Clinical trials of acupuncture of Jiaji (EX-B2) for treatment of gastrointestinal dysfunction in sepsis patients. Zhen Ci Yan Jiu 2019;44:43–6.
[2] Wu FW. Effect of Electro-acupuncture upon Zusanli on Inflammatory Response and Immune Function in the Patients of Sepsis. J Emerg Trad Chinese Med 2016;9:1794–7.
[3] Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS medicine. 2009; 6(7):e1000100.
[4] Levy MM, Fink MP, Marshall JC, et al. 2001 International Sepsis Definitions Conference . Intensive Care Med 2003;29:530–8.
[5] Volk HD, Reinke P, Krausch D, Zuckermann H, Asadullah K, Muller JM, et al. Monocyte deactivation rationale for a new therapeutic strategy in sepsis. Intens Care Med 1996;22:474-481.
[6] Zhao NX, Gao W, Huang YX. Effects of electro-acupuncture of “Zusanli” on T lymphocyte subsets in rats. Acupunct Res (Chin) 2001;26:15-18.
[7] Gao W, Huang YX, Chen H, Zhang HX, Sun DY, Wang QL. Effects of electroacupuncture of “Zusanli” on braingut peptide contents in rat pituitary gland and peripheral blood and on the immune system. Acupuncture Res (Chin) 2002;27:50-55.

Downloads: 186
Visits: 20424

Sponsors, Associates, and Links

All published work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2016 - 2031 Clausius Scientific Press Inc. All Rights Reserved.