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To explore the mechanism of Epimedium in the treatment of osteoporosis based on network pharmacology

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DOI: 10.23977/medcm.2021.030209 | Downloads: 8 | Views: 972

Author(s)

Lei Zhang 1, Feng Yang 1

Affiliation(s)

1 Shaanxi University of Chinese Medicine

Corresponding Author

Feng Yang

ABSTRACT

Objective To screen the target and signal pathway of Epimedium active components in the treatment of osteoporosis by using network pharmacology, and to provide more promising evidence for the treatment of osteoporosis. Methods TCMSP analysis platform was used to screen the information of active constituents and active constituents of traditional Chinese medicine.Uniprot database and Excel were used to find the gene names of the active components.The disease-related targets were collected from Genecards database and OMim DRUGBANK database, and the overlapping values between the three databases were deleted. The intersection of Chinese medicine target genes and disease target genes was obtained by Venny software, and the obtained common genes of Chinese medicine and disease were input into Cytoscape software to obtain the disease-Chinese medicine and target regulatory network. Then, String software and Cytoscape software were used to construct the protein interaction network for the common target of TCM and disease. Common target genes were enriched by GO and KEGG function analysis, and the common target pathway was constructed by Cytoscape software.Results Twenty-three active components and 72 common target genes of Epimedium for the treatment of osteoporosis were screened. Concluded that the mechanism may be related to the AGE of diabetes complications -RAGE signaling pathways (AGE-RAGEsignalingpathwayindiabetic complications) way of TNF signaling pathways (TNFsignalingpathway) cancer (Pathwaysincancer) signaling pathway HIF - 1 signalingpathway (HIF - 1) etc, and Bai Jie - 6 gene (IL - 6) RAC - alpha serine/threonine protein...Vascular endothelial growth factor (AKT1)...Tumor necrosis factor (TNF) cell tumor antigen p53(TP53) may play a key role.Conclusion Based on network pharmacology, the mechanism of action of Epimedium in the treatment of osteoporosis was discussed, which provided an effective basis for the treatment of the disease.

KEYWORDS

network pharmacology, Epimedium, Osteoporosis, Core target signaling pathway

CITE THIS PAPER

Lei Zhang, Feng Yang, To explore the mechanism of Epimedium in the treatment of osteoporosis based on network pharmacology. MEDS Chinese Medicine (2021) 3: 35-43. DOI: http://dx.doi.org/10.23977/medcm.2021.030209

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