Explore the Future Direction of HIV-1 Latent Virus
DOI: 10.23977/medsc.2021.020201 | Downloads: 8 | Views: 999
Jiaxin Liu 1
1 Department of Biology, Baylor University, Waco, 76706, USA
Corresponding AuthorJiaxin Liu
Human immunodeficiency virus-1 (HIV-1) can be latent in quiescent CD4+ T cells, in which the viral DNA is silent in transcription and undetectable by the immune system. HIV-1 proviral DNA survives in the latent form primarily in quiescent CD4+ T cells. Although the current antiretroviral therapy (ART) can effectively inhibit the virus replication in HIV-1 infected people and suppress HIV to an undetectable level, ART does not work on latent HIV-1. Therefore, current ART cannot completely cure HIV-1 infected people, and HIV-1 infected people must use life-long ART to inhibit virus replication. Therefore, developing drugs that can act directly on latent HIV-1 is the biggest obstacle to the treatment of HIV-1 infection.
KEYWORDSBRD4, HIV-1, Latency, Tat, Reactivation
CITE THIS PAPER
Jiaxin Liu. Explore the Future Direction of HIV-1 Latent Virus. MEDS Clinical Medicine (2021) 2: 1-3. DOI: http://dx.doi.org/10.23977/medsc.2021.020201.
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