Education, Science, Technology, Innovation and Life
Open Access
Sign In

Hsa-Mir-29b-3p Inhibits Biological Development of Cancer by Targeting Inhibiting Expression of Cav2

Download as PDF

DOI: 10.23977/medsc.2021.020105 | Downloads: 6 | Views: 1144

Author(s)

BAI Wen-juan 1, LIU Yu 2

Affiliation(s)

1 Department of Biochemistry, College of Lab Medicine, Hebei North University, Zhangjiakou 075000, China
2 Laboratory Animal Center, Hebei North University, Zhangjiakou 075000, China

Corresponding Author

LIU Yu

ABSTRACT

Objective: To determine the role of hsa-miR-29b-3p in lung adenocarcinoma. Methods: Download miRNA mature for TCGA-LUAD, mRNA. from TCGA Database Differ differential analysis of miR-29b-3p based on the downloaded data obtained the differential gene expression matrix of miRNA and mRNA, and then intersects with the target genes predicted by multiple databases to obtain the target gene. Further KEGG enrichment analysis was performed on the target gene.Result:miR-29b-3p is significantly highly expressed in tumor tissue, its downstream regulated lower expression of the target gene CAV2 in cancer, and its lower expression indicates a better prognosis. KEGG enrichment results indicate significant enrichment of CAV2 in syndecan 2 pathway, Proteoglycans in cancer, ESR-mediated signaling, Signaling by Nuclear Receptors, Signal Transduction etc in Pathways associated with signal transduction and cell processes. Conclusion:hsa-miR-29b-3p suppresses cancer cell proliferation, adhesion, angiogenesis and metastasis, helping to inhibit the development of lung adenocarcinoma and can be used as a new therapeutic target.

KEYWORDS

Bioinformatics, Lung adenocarcinoma, Hyaluronic acid, Prognostic genes

CITE THIS PAPER

BAI Wen-juan, LIU Yu. Hsa-Mir-29b-3p Inhibits Biological Development of Cancer by Targeting Inhibiting Expression of Cav2. MEDS Clinical Medicine (2021) 2: 27-32. DOI: http://dx.doi.org/10.23977/medsc.2021.020105.

REFERENCES

[1] Liao HX, Zhang ZH, Chen HL, Huang YM, Liu ZL, Huang J. CircHYBID regulates hyaluronan metabolism in chondrocytes via hsa-miR-29b-3p/TGF-β1 axis. Mol Med. 2021 May 31;27(1):56.
[2] Bai ZM, Li XF, Yang Y, Yang YF, Lv DR, Tang LL. Propofol inhibited gastric cancer proliferation via the hsa-miR-328-3p/STAT3 pathway. Clin Transl Oncol. 2021 Mar 27.
[3] Li C, Wang P, Du J, Chen J, Liu W, Ye K. LncRNA RAD51-AS1/miR-29b/c-3p/NDRG2 crosstalk repressed proliferation, invasion and glycolysis of colorectal cancer. IUBMB Life. 2021 Jan;73(1):286-298.
[4] Fujimoto T, Kogo H, Ishiguro K, Tauchi K, Nomura R. Caveolin-2 is targeted to lipid droplets, a new “membrane domain” in the cell. J Cell Biol. 2001 Mar 5;152(5):1079-85.
[5] Zhu Y, Tian J, Peng X, Wang X, Yang N, Ying P, Wang H, Li B, Li Y, Zhang M, Cai Y, Lu Z, Niu S, Li Y, Zhong R, Chang J, Miao X. A genetic variant conferred high expression of CAV2 promotes pancreatic cancer progression and associates with poor prognosis. Eur J Cancer. 2021 Jul;151:94-105.
[6] Liu F, Shangli Z, Hu Z. CAV2 promotes the growth of renal cell carcinoma through the EGFR/PI3K/Akt pathway. Onco Targets Ther. 2018 Sep 25;11:6209-6216.
[7] Liu ZQ, Ren JJ, Zhao JL, Zang J, Long QF, Du JJ, Jia XT, Gu NB, Di ZL, Qian YH, Li SZ. MicroRNA-144 represses gliomas progression and elevates susceptibility to Temozolomide by targeting CAV2 and FGF7. Sci Rep. 2020 Mar 5;10(1):4155.
[8] Gerstenberger W, Wrage M, Kettunen E, Pantel K, Anttila S, Steurer S, Wikman H. Stromal Caveolin-1 and Caveolin-2 Expression in Primary Tumors and Lymph Node Metastases. Anal Cell Pathol (Amst). 2018 Apr 10;2018:8651790.

Downloads: 4926
Visits: 218217

Sponsors, Associates, and Links


All published work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2016 - 2031 Clausius Scientific Press Inc. All Rights Reserved.