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Research on Role of Regulatory Polypeptide Ac-Sdkp in Restraining Silicosis Fibrosis

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DOI: 10.23977/medsc.2021.020102 | Downloads: 7 | Views: 1291


Zhangying Meng 1


1 North China University of Science and Technology, Tangshan, Hebei, 063210, China

Corresponding Author

Zhangying Meng


Objective: To explore the specific role of regulatory polypeptide Ac-SDKP in restraining silicosis fibrosis. Methods: The study starts from February 2020 to February 2021. 20 Wistar rats are selected as subjects of the study, and they are randomly divided into treatment group and model group. The treatment group is treated with anti-fibrosis of regulatory polypeptide Ac-SDKP, while the model group is not treated. And the expressions of p-CREB, PKA, and cAMP in the two groups of rats are observed. Results: The expressions of p-CREB, PKA and cAMP in the treatment group are higher than those in the model group (P < 0.05). Conclusion: Silicosis fibrosis can be inhibited by the regulatory polypeptide Ac-SDKP.


Silicosis fibrosis, Regulatory polypeptide ac-sdkp, P-creb, Pka, Camp


Zhangying Meng. Research on Role of Regulatory Polypeptide Ac-Sdkp in Restraining Silicosis Fibrosis. MEDS Clinical Medicine (2021) 2: 6-9. DOI:


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